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    GPRASP2 G protein-coupled receptor associated sorting protein 2 [ Homo sapiens ]

    Gene ID: 114928, updated on 11-May-2012
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    Summary

    Official Symbol
    GPRASP2provided by HGNC
    Official Full Name
    G protein-coupled receptor associated sorting protein 2provided by HGNC
    Primary source
    HGNC:25169
    Locus tag
    RP4-769N13.4
    See related
    Ensembl:ENSG00000158301; HPRD:06612; Vega:OTTHUMG00000022059
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GASP2; FLJ35662; FLJ37327
    Summary
    The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
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    Genomic context

    Location :
    Xq22.1
    Sequence :
    Chromosome: X; NC_000023.10 (101967104..101972661)
    See GPRASP2 in Epigenomics, MapViewer

    Chromosome X - NC_000023.10Genomic Context describing neighboring genes Neighboring gene ARMCX5-GPRASP2 readthrough Neighboring gene G protein-coupled receptor associated sorting protein 1 Neighboring gene BEN domain containing 7 pseudogene Neighboring gene basic helix-loop-helix domain containing, class B, 9 Neighboring gene uncharacterized LOC100287765 Neighboring gene MT-ND2 pseudogene 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    2. Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia. Piton A, et al. Mol Psychiatry, 2011 Aug. PMID 20479760.
    3. Defining the human deubiquitinating enzyme interaction landscape. Sowa ME, et al. Cell, 2009 Jul 23. PMID 19615732.
    4. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677.
    5. Huntingtin interacts with the receptor sorting family protein GASP2. Horn SC, et al. J Neural Transm, 2006 Aug. PMID 16835690.

    See all (15) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
    2. that huntingtin protein and GASP2 form a complex in cotransfected mammalian cells
      Title: Huntingtin interacts with the receptor sorting family protein GASP2.
    Submit: New GeneRIF Correction
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_001004051.1 NP_000675.1 ADRB1    BIND  PubMed GASP-2 interacts with beta-1-AR. 
    NP_001004051.1 AAA35640.1 CALCR    BIND  PubMed GASP-2 interacts with CALCR. 
    NP_001004051.1 NP_000729.2 CHRM1    BIND  PubMed GASP-2 interacts with M1. 
    NP_001004051.1 NP_000730.1 CHRM2    BIND  PubMed GASP-2 interacts with M2. 
    NP_001004051.1 NP_071640.1 HRH2    BIND  PubMed GASP-2 interacts with H2. 
    NP_001004051.1 NP_000863.1 HTR7    BIND  PubMed GASP-1 interacts with 5-HT7. 
    Q96D09 P08588 ADRB1    HPRD  PubMed  
    Q96D09 P30988 CALCR    HPRD  PubMed  
    Q96D09 P11229 CHRM1    HPRD  PubMed  
    Q96D09 P08172 CHRM2    HPRD  PubMed  
    Q96D09 P25021 HRH2    HPRD  PubMed  
    Q96D09 P34969 HTR7    HPRD  PubMed  
    Q96D09 P42858 HTT    HPRD  PubMed  
    Q96D09 Q9P2H0 KIAA1377    HPRD  PubMed  
    BioGRID:125399 BioGRID:114847 ARHGEF6    BioGRID  PubMed Two-hybrid 
    BioGRID:125399 BioGRID:114457 BTRC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125399 BioGRID:118061 DISC1    BioGRID  PubMed Two-hybrid 
    BioGRID:125399 BioGRID:116258 STMN2    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Genotypes

    Readthrough ARMCX5-GPRASP2

    Readthrough gene: ARMCX5-GPRASP2, Included gene: ARMCX5

    Homology

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    General protein information

    Preferred Names
    G-protein coupled receptor-associated sorting protein 2
    Names
    G-protein coupled receptor-associated sorting protein 2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021322.1 RefSeqGene

      Range
      4848..10405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001004051.3 → NP_001004051.1  G-protein coupled receptor-associated sorting protein 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK123832, AL522674, BC051707
      Consensus CDS
      CCDS14501.1
      UniProtKB/TrEMBL
      B3KW05
      UniProtKB/Swiss-Prot
      Q96D09
      Conserved Domains (1) summary
      pfam04826
      Location:593 – 837
      Blast Score: 529
      Arm_2; Armadillo-like

    2. NM_001184874.2 → NP_001171803.1  G-protein coupled receptor-associated sorting protein 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All five variants encode the same protein.
      Source sequence(s)
      AK123832, BC051707, DA389655
      Consensus CDS
      CCDS14501.1
      UniProtKB/TrEMBL
      B3KW05
      UniProtKB/Swiss-Prot
      Q96D09
      Related
      ENSP00000437872, ENST00000543253
      Conserved Domains (1) summary
      pfam04826
      Location:593 – 837
      Blast Score: 529
      Arm_2; Armadillo-like

    3. NM_001184875.2 → NP_001171804.1  G-protein coupled receptor-associated sorting protein 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK123832, BC051707, DA231935
      Consensus CDS
      CCDS14501.1
      UniProtKB/TrEMBL
      B3KW05
      UniProtKB/Swiss-Prot
      Q96D09
      Related
      ENSP00000437394, ENST00000535209
      Conserved Domains (1) summary
      pfam04826
      Location:593 – 837
      Blast Score: 529
      Arm_2; Armadillo-like

    4. NM_001184876.2 → NP_001171805.1  G-protein coupled receptor-associated sorting protein 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK123832, BC051707, DA776293
      Consensus CDS
      CCDS14501.1
      UniProtKB/TrEMBL
      B3KW05
      UniProtKB/Swiss-Prot
      Q96D09
      Conserved Domains (1) summary
      pfam04826
      Location:593 – 837
      Blast Score: 529
      Arm_2; Armadillo-like

    5. NM_138437.5 → NP_612446.1  G-protein coupled receptor-associated sorting protein 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All five variants encode the same protein.
      Source sequence(s)
      AK123832, BC051707
      Consensus CDS
      CCDS14501.1
      UniProtKB/TrEMBL
      B3KW05
      UniProtKB/Swiss-Prot
      Q96D09
      Related
      ENSP00000339057, OTTHUMP00000023714, ENST00000332262, OTTHUMT00000057626
      Conserved Domains (1) summary
      pfam04826
      Location:593 – 837
      Blast Score: 529
      Arm_2; Armadillo-like

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000023.10 Reference GRCh37.p5 Primary Assembly

      Range
      101967104..101972661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000155.1 Alternate HuRef

      Range
      91571283..91638248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL035427.17 CAI43060.1
    genomic CH471190.2 EAW54727.1
      EAW54728.1
      EAW54729.1
    mRNA AA906216.1 None
    mRNA AK092981.1 None
    mRNA AK094646.1 None
    mRNA AK096067.1 None
    mRNA AK123832.1 BAG53967.1
    mRNA AL522674.3 None
    mRNA AL832187.1 None
    mRNA BC013576.1 AAH13576.1
    mRNA BC036772.1 AAH36772.1
    mRNA BC051707.1 None
    mRNA BG719561.1 None
    mRNA BX509838.1 None
    mRNA DA231935.1 None
    mRNA DA238794.1 None
    mRNA DA333852.1 None
    mRNA DA389655.1 None
    mRNA DA776293.1 None
    other-genetic AM393617.1 CAL38493.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96D09.1 GenPept UniProtKB/Swiss-Prot:Q96D09
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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