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OSBPL6 oxysterol binding protein-like 6 [ Homo sapiens (human) ]

Gene ID: 114880, updated on 17-Feb-2015
Official Symbol
OSBPL6provided by HGNC
Official Full Name
oxysterol binding protein-like 6provided by HGNC
Primary source
HGNC:HGNC:16388
See related
Ensembl:ENSG00000079156; HPRD:09476; MIM:606734; Vega:OTTHUMG00000132579
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORP6
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Orthologs
See OSBPL6 in MapViewer
Location:
2q32.1
Exon count:
27
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (178194481..178399433)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (179059208..179264160)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 45 Neighboring gene RNA, U5E small nuclear 9, pseudogene Neighboring gene uncharacterized LOC101927027 Neighboring gene protein kinase, interferon-inducible double stranded RNA dependent activator Neighboring gene deafness, autosomal recessive 59 Neighboring gene nuclear distribution gene C homolog (A. nidulans) pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genetic variants associated with breast size also influence breast cancer risk.
NHGRI GWA Catalog
Impact of ancestry and common genetic variants on QT interval in African Americans.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of oxysterol binding protein-like 6 (OSBPL6) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with oxysterol binding protein-like 6 (OSBPL6) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ36583, FLJ41254, MGC59642, DKFZp686M06110

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
oxysterol-binding protein-related protein 6
Names
oxysterol-binding protein-related protein 6
ORP-6
OSBP-related protein 6

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201480.1NP_001188409.1  oxysterol-binding protein-related protein 6 isoform c

    See proteins identical to NP_001188409.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an additional in-frame coding exon, as compared to variant 1. The resulting isoform (c) is the longest and has an additional segment, as compared to isoform a.
    Source sequence(s)
    AB208898, AC009948, AC011743, CA425863
    Consensus CDS
    CCDS56150.1
    UniProtKB/Swiss-Prot
    Q9BZF3
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:595943
    Oxysterol_BP; Oxysterol-binding protein
  2. NM_001201481.1NP_001188410.1  oxysterol-binding protein-related protein 6 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (d) lacks an internal segment, as compared to isoform a.
    Source sequence(s)
    AB208898, AC009948, AC011743, CA425863
    Consensus CDS
    CCDS56152.1
    UniProtKB/Swiss-Prot
    Q9BZF3
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:539887
    Oxysterol_BP; Oxysterol-binding protein
  3. NM_001201482.1NP_001188411.1  oxysterol-binding protein-related protein 6 isoform e

    See proteins identical to NP_001188411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame coding exon, as compared to variant 1. The resulting isoform (e) lacks an internal segment, as compared to isoform a.
    Source sequence(s)
    AB208898, AC009948, AC011743, AF462443, CA425863
    Consensus CDS
    CCDS56151.1
    UniProtKB/Swiss-Prot
    Q9BZF3
    Related
    ENSP00000352713, ENST00000359685
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:534882
    Oxysterol_BP; Oxysterol-binding protein
  4. NM_032523.3NP_115912.1  oxysterol-binding protein-related protein 6 isoform a

    See proteins identical to NP_115912.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript. It encodes isoform a which contains both a pleckstrin homology domain and a sterol-binding domain.
    Source sequence(s)
    AB208898, AC009948, AC011743, AF323728, CA425863
    Consensus CDS
    CCDS2277.1
    UniProtKB/Swiss-Prot
    Q9BZF3
    Related
    ENSP00000190611, OTTHUMP00000205303, ENST00000190611, OTTHUMT00000334393
    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:570918
    Oxysterol_BP; Oxysterol-binding protein
  5. NM_145739.2NP_665682.1  oxysterol-binding protein-related protein 6 isoform b

    See proteins identical to NP_665682.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three exons from the 5' end and has an alternate 5' exon and an in-frame internal exon in the CDS, as compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus and an additional segment, as compared to isoform a.
    Source sequence(s)
    AB208898, AC009948, AC011743, CA425863
    Consensus CDS
    CCDS2278.1
    UniProtKB/Swiss-Prot
    Q9BZF3
    Conserved Domains (2) summary
    cd13287
    Location:45167
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:574922
    Oxysterol_BP; Oxysterol-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38 Primary Assembly

    Range
    178194481..178399433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712232.1XP_006712295.1  

    See proteins identical to XP_006712295.1

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:559907
    Oxysterol_BP; Oxysterol-binding protein
  2. XM_006712231.1XP_006712294.1  

    Conserved Domains (2) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam01237
    Location:564912
    Oxysterol_BP; Oxysterol-binding protein
  3. XM_005246268.1XP_005246325.1  

    See proteins identical to XP_005246325.1

    UniProtKB/Swiss-Prot
    Q9BZF3
    Related
    ENSP00000349591, OTTHUMP00000205305, ENST00000357080, OTTHUMT00000334395
    Conserved Domains (1) summary
    cd13287
    Location:66188
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    179065294..179270178
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 Alternate HuRef

    Range
    170930068..171134835
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)