Format

Send to:

Choose Destination

Adam10 a disintegrin and metallopeptidase domain 10 [ Mus musculus (house mouse) ]

Gene ID: 11487, updated on 17-May-2016
Official Symbol
Adam10provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 10provided by MGI
Primary source
MGI:MGI:109548
See related
Ensembl:ENSMUSG00000054693 Vega:OTTMUSG00000033211
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
kuz; MADM; kuzbanian; 1700031C13Rik
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]
Orthologs
Location:
9 D; 9 39.53 cM
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 9 NC_000075.6 (70679001..70780229)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (70526808..70628036)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 63, member B Neighboring gene predicted gene, 31872 Neighboring gene cytochrome c, pseudogene 1 Neighboring gene lipase, hepatic Neighboring gene ribosomal RNA processing 7 homolog A pseudogene Neighboring gene predicted gene, 32017

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH2 domain binding NAS
Non-traceable Author Statement
more info
PubMed 
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
metalloendopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
metallopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
metallopeptidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
peptidase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch receptor processing NAS
Non-traceable Author Statement
more info
PubMed 
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
PMA-inducible membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
constitutive protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane protein ectodomain proteolysis ISO
Inferred from Sequence Orthology
more info
 
monocyte activation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
nucleocytoplasmic transport NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein processing IDA
Inferred from Direct Assay
more info
PubMed 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
Golgi-associated vesicle ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
tetraspanin-enriched microdomain ISO
Inferred from Sequence Orthology
more info
 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
disintegrin and metalloproteinase domain-containing protein 10
Names
a disintegrin and metalloprotease domain (ADAM) 10
kuzbanian protein homolog
mammalian disintegrin-metalloprotease
NP_031425.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007399.4NP_031425.2  disintegrin and metalloproteinase domain-containing protein 10 preproprotein

    See identical proteins and their annotated locations for NP_031425.2

    Status: REVIEWED

    Source sequence(s)
    AC160636, AK031857, BC057346, BC066207, BE654195, BY205591
    Consensus CDS
    CCDS23323.1
    UniProtKB/Swiss-Prot
    O35598
    UniProtKB/TrEMBL
    Q6NZC0
    Related
    ENSMUSP00000063839, OTTMUSP00000044639, ENSMUST00000067880, OTTMUST00000083164
    Conserved Domains (4) summary
    cd04270
    Location:221460
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:467550
    Disintegrin; Disintegrin
    pfam01421
    Location:225452
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:43156
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p3 C57BL/6J

    Range
    70679001..70780229
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242657.1XP_011240959.1  

    Conserved Domains (4) summary
    cd04270
    Location:225464
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam00200
    Location:471554
    Disintegrin; Disintegrin
    pfam01421
    Location:229456
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:47160
    Pep_M12B_propep; Reprolysin family propeptide

Alternate Mm_Celera

Genomic

  1. AC_000031.1 Alternate Mm_Celera

    Range
    67896038..67997081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)