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Ada adenosine deaminase [ Mus musculus (house mouse) ]

Gene ID: 11486, updated on 28-May-2016
Official Symbol
Adaprovided by MGI
Official Full Name
adenosine deaminaseprovided by MGI
Primary source
MGI:MGI:87916
See related
Ensembl:ENSMUSG00000017697 Vega:OTTMUSG00000001154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Orthologs
Location:
2 84.44 cM; 2 H3
Exon count:
12
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (163726571..163750239, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (163552320..163575913, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene serine incorporator 3 Neighboring gene RIKEN cDNA 0610039K10 gene Neighboring gene protein kinase inhibitor, gamma Neighboring gene uncharacterized LOC102639518 Neighboring gene WNT1 inducible signaling pathway protein 2 Neighboring gene potassium channel, subfamily K, member 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
adenosine deaminase activity IDA
Inferred from Direct Assay
more info
PubMed 
adenosine deaminase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenosine deaminase activity ISO
Inferred from Sequence Orthology
more info
 
deaminase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
purine nucleoside binding ISO
Inferred from Sequence Orthology
more info
 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Peyer's patch development IMP
Inferred from Mutant Phenotype
more info
PubMed 
T cell activation ISO
Inferred from Sequence Orthology
more info
 
adenosine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
adenosine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
adenosine catabolic process ISO
Inferred from Sequence Orthology
more info
 
adenosine metabolic process ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
dATP catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
dATP catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
deoxyadenosine catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
deoxyadenosine catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germinal center B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histamine secretion ISO
Inferred from Sequence Orthology
more info
 
hypoxanthine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
hypoxanthine salvage IBA
Inferred from Biological aspect of Ancestor
more info
 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inosine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
inosine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
inosine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of adenosine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
negative regulation of adenosine receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of circadian sleep/wake cycle, non-REM sleep ISO
Inferred from Sequence Orthology
more info
 
negative regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of leukocyte migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mature B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mucus secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of mucus secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of penile erection IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
nucleotide metabolic process IEA
Inferred from Electronic Annotation
more info
 
placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell differentiation in thymus IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of alpha-beta T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of calcium-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of heart rate IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smooth muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
purine nucleotide salvage ISO
Inferred from Sequence Orthology
more info
 
purine ribonucleoside monophosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
regulation of T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell-cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to morphine ISO
Inferred from Sequence Orthology
more info
 
response to vitamin E ISO
Inferred from Sequence Orthology
more info
 
trophectodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
xanthine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
lysosome ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
adenosine deaminase
Names
adenosine aminohydrolase
NP_001258981.1
NP_031424.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001272052.1NP_001258981.1  adenosine deaminase

    See identical proteins and their annotated locations for NP_001258981.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075899, AL591490, D19191
    Consensus CDS
    CCDS17015.1
    UniProtKB/Swiss-Prot
    P03958
    UniProtKB/TrEMBL
    Q4FK28
    Conserved Domains (1) summary
    cd01320
    Location:8336
    ADA; Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in ...
  2. NM_007398.4NP_031424.1  adenosine deaminase

    See identical proteins and their annotated locations for NP_031424.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075899, AL591490
    Consensus CDS
    CCDS17015.1
    UniProtKB/Swiss-Prot
    P03958
    UniProtKB/TrEMBL
    Q4FK28
    Related
    ENSMUSP00000017841, OTTMUSP00000001096, ENSMUST00000017841, OTTMUST00000002247
    Conserved Domains (1) summary
    cd01320
    Location:8336
    ADA; Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    163726571..163750239 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    169670296..169693995 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)