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Aspa aspartoacylase [ Mus musculus (house mouse) ]

Gene ID: 11484, updated on 19-Jul-2014
Official Symbol
Aspaprovided by MGI
Official Full Name
aspartoacylaseprovided by MGI
Primary source
MGI:87914
Locus tag
RP23-213I10.1
See related
Ensembl:ENSMUSG00000020774; Vega:OTTMUSG00000006136
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acy2; nur7; Acy-2
Summary
This gene encodes an enzyme that deacteylates N-acetyl-L-aspartic acid (NAA) in the brain to yield acetate and L-aspartate. In humans, alterations in neuronal NAA concentration are associated with many neurodegenerative diseases (decrease associated with epilepsy, multiple sclerosis, myotrophic lateral sclerosis, and Alzheimer's disease; increase associated with Canavan disease). In mouse, mutations in this gene, which cause accumulation of NAA, result in demyelination and spongy degeneration in the CNS and serve as a pathophysiological model for Canavan disease. [provided by RefSeq, Dec 2012]
See Aspa in Epigenomics, MapViewer
Location:
11 B4; 11
Exon count:
9
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (73304988..73326980, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily V, member 1 Neighboring gene transient receptor potential cation channel, subfamily V, member 3 Neighboring gene spermatogenesis associated 22 Neighboring gene olfactory receptor 20

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
aminoacylase activity TAS
Traceable Author Statement
more info
PubMed 
aspartoacylase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acetate metabolic process TAS
Traceable Author Statement
more info
PubMed 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
aspartoacylase
Names
aspartoacylase
aminoacylase-2
aspartoacylase (aminoacylase) 2
NP_075602.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_023113.5NP_075602.2  aspartoacylase

    See proteins identical to NP_075602.2

    Status: REVIEWED

    Source sequence(s)
    AI527854, AK002859
    Consensus CDS
    CCDS25005.1
    UniProtKB/Swiss-Prot
    Q8R3P0
    Related
    ENSMUSP00000021119, OTTMUSP00000006437, ENSMUST00000021119, OTTMUST00000013867
    Conserved Domains (2) summary
    cd06909
    Location:11299
    Blast Score: 1286
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9299
    Blast Score: 702
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    73304988..73326980
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532012.1XP_006532075.1  

    See proteins identical to XP_006532075.1

    UniProtKB/Swiss-Prot
    Q8R3P0
    Conserved Domains (2) summary
    cd06909
    Location:11299
    Blast Score: 1286
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9299
    Blast Score: 702
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
  2. XM_006532011.1XP_006532074.1  

    See proteins identical to XP_006532074.1

    UniProtKB/Swiss-Prot
    Q8R3P0
    Conserved Domains (2) summary
    cd06909
    Location:11299
    Blast Score: 1286
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9299
    Blast Score: 702
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
  3. XM_006532013.1XP_006532076.1  

    Conserved Domains (2) summary
    cd06909
    Location:47299
    Blast Score: 1062
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:45299
    Blast Score: 571
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
  4. XM_006532010.1XP_006532073.1  

    Conserved Domains (2) summary
    cd06909
    Location:47335
    Blast Score: 1293
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:45335
    Blast Score: 702
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

Reference GRCm38.p2 NOD/MrkTac

Genomic

  1. NT_166317.2 

    Range
    396882..418860
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006536287.1XP_006536350.1  

    See proteins identical to XP_006536350.1

    UniProtKB/Swiss-Prot
    Q8R3P0
    Conserved Domains (2) summary
    cd06909
    Location:11299
    Blast Score: 1287
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9299
    Blast Score: 703
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
  2. XM_006536286.1XP_006536349.1  

    See proteins identical to XP_006536349.1

    UniProtKB/Swiss-Prot
    Q8R3P0
    Conserved Domains (2) summary
    cd06909
    Location:11299
    Blast Score: 1287
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:9299
    Blast Score: 703
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
  3. XM_006536288.1XP_006536351.1  

    Conserved Domains (2) summary
    cd06909
    Location:47299
    Blast Score: 1062
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:45299
    Blast Score: 573
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family
  4. XM_006536285.1XP_006536348.1  

    Conserved Domains (2) summary
    cd06909
    Location:47335
    Blast Score: 1293
    M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily
    pfam04952
    Location:45335
    Blast Score: 703
    AstE_AspA; Succinylglutamate desuccinylase / Aspartoacylase family

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    80842205..80861577
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)