Acvr2b activin receptor IIB [Mus musculus] - Gene

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Summary

Official Symbol: Acvr2bprovided by MGI
Official Full Name: activin receptor IIBprovided by MGI
Primary source: MGI:87912
See related: Ensembl:ENSMUSG00000061393
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ActRIIB; MGC118477

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Genomic context

Location :: 9 F3; 9

Sequence :: Chromosome: 9; NC_000075.6 (119402501..119433515)

See Acvr2b in Epigenomics, MapViewer

Chromosome 9 - NC_000075.6 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Functional redundancy in osteoblast differentiation is observed between bone morphogenetic protein receptor BMPR-II and ActR-IIB.
Title: Functional redundancy of type II BMP receptor and type IIB activin receptor in BMP2-induced osteoblast differentiation.
Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice.
Title: Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice.
Akt isoforms are not essential for for the ability of ActRIIB inhibition to regulate muscle size and function .
Title: Akt deficiency attenuates muscle size and function but not the response to ActRIIB inhibition.
Data suggest that BMP3 exerts its effects in the skeleton by altering signaling through ActRIIB in chondrocytes and the periosteum, and this results in defects in bone collar formation and late hypertrophic chondrocyte maturation.
Title: Overexpression of BMP3 in the developing skeleton alters endochondral bone formation resulting in spontaneous rib fractures.
expression of MSTN and its associated binding proteins can be modulated in adipose tissue and skeletal muscle by chronic obesity
Title: Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice.
genetic evidence strongly suggested that ActRIIB and Smad2 function in the same signaling pathway to regulate axial patterning and pancreas islet formation by means of a threshold mechanism.
Title: Genetic interactions between activin type IIB receptor and Smad2 genes in asymmetrical patterning of the thoracic organs and the development of pancreas islets.
Activin type IIB(ActRIIB) and its subfamily receptor, Activin type IIA (ActRIIA), cooperatively mediate the Gdf11 signal in patterning the axial vertebrae
Title: Activin type IIA and IIB receptors mediate Gdf11 signaling in axial vertebral patterning.
ActRIIB is expressed in the early development of thymocytes.
Title: Inhibins are the major activin ligands expressed during early thymocyte development.
ActRIIB plays a role in the specification of left-sidedness in developing mice
Title: Gene-dosage-sensitive genetic interactions between inversus viscerum (iv), nodal, and activin type IIB receptor (ActRIIB) genes in asymmetrical patterning of the visceral organs along the left-right axis.

Submit: New GeneRIF Correction

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (knock-out) (3) 1 citation

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Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
activin binding	IDA Inferred from Direct Assay more info	PubMed
activin binding	IPI Inferred from Physical Interaction more info	PubMed
activin binding	ISO Inferred from Sequence Orthology more info
activin-activated receptor activity	IEA Inferred from Electronic Annotation more info
growth factor binding	IMP Inferred from Mutant Phenotype more info	PubMed
growth factor binding	IPI Inferred from Physical Interaction more info	PubMed
growth factor binding	ISO Inferred from Sequence Orthology more info
inhibin beta-A binding	ISO Inferred from Sequence Orthology more info
inhibin beta-B binding	ISO Inferred from Sequence Orthology more info
kinase activity	IEA Inferred from Electronic Annotation more info
metal ion binding	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IEA Inferred from Electronic Annotation more info
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
protein serine/threonine/tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
receptor signaling protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info
NOT transforming growth factor beta binding	IDA Inferred from Direct Assay more info	PubMed
transforming growth factor beta-activated receptor activity	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
BMP signaling pathway	ISO Inferred from Sequence Orthology more info
activation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
anterior/posterior pattern specification	IGI Inferred from Genetic Interaction more info	PubMed
anterior/posterior pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
determination of left/right symmetry	IGI Inferred from Genetic Interaction more info	PubMed
determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
embryonic foregut morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
gastrulation with mouth forming second	IGI Inferred from Genetic Interaction more info	PubMed
heart development	IGI Inferred from Genetic Interaction more info	PubMed
heart development	IMP Inferred from Mutant Phenotype more info	PubMed
insulin secretion	IGI Inferred from Genetic Interaction more info	PubMed
kidney development	IGI Inferred from Genetic Interaction more info	PubMed
kidney development	IMP Inferred from Mutant Phenotype more info	PubMed
lung development	IGI Inferred from Genetic Interaction more info	PubMed
mesoderm development	IGI Inferred from Genetic Interaction more info	PubMed
odontogenesis of dentin-containing tooth	IGI Inferred from Genetic Interaction more info	PubMed
odontogenesis of dentin-containing tooth	IMP Inferred from Mutant Phenotype more info	PubMed
organ growth	IGI Inferred from Genetic Interaction more info	PubMed
palate development	IGI Inferred from Genetic Interaction more info	PubMed
palate development	IMP Inferred from Mutant Phenotype more info	PubMed
pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
pattern specification process	IGI Inferred from Genetic Interaction more info	PubMed
phosphorylation	IEA Inferred from Electronic Annotation more info
positive regulation of activin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
post-embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
post-embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of signal transduction	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	ISO Inferred from Sequence Orthology more info
response to glucose stimulus	IGI Inferred from Genetic Interaction more info	PubMed
signal transduction	ISO Inferred from Sequence Orthology more info
skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
skeletal system morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
transmembrane receptor protein serine/threonine kinase signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cell	IGI Inferred from Genetic Interaction more info	PubMed
cell surface	ISO Inferred from Sequence Orthology more info
cytoplasm	ISO Inferred from Sequence Orthology more info
integral to membrane	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: activin receptor type-2B

Names: activin receptor type-2B; ACTR-IIB; activin receptor type IIB

NP_031423.1

EC 2.7.11.30

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007397.2 → NP_031423.1 activin receptor type-2B precursor

Status: PROVISIONAL

Source sequence(s)

AC166052

Consensus CDS

CCDS23615.1

UniProtKB/Swiss-Prot

P27040

Related

ENSMUSP00000126108, ENSMUST00000165044

Conserved Domains (3) summary

cd00180
Location:222 – 420
Blast Score: 351

PKc; Catalytic domain of Protein Kinases

pfam01064
Location:27 – 117
Blast Score: 161

Activin_recp; Activin types I and II receptor domain

pfam00069
Location:215 – 495
Blast Score: 478

Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: Build 38.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38 C57BL/6J

Genomic

NC_000075.6 Reference GRCm38 C57BL/6J

Range

119402501..119433515

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000031.1 Alternate Mm_Celera

Range

119872380..119903791

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AC166052.5 (14912..45927)	None
genomic	CH466587.2	EDL09216.1	mixed
		EDL09217.1	mixed
		EDL09218.1	mixed
mRNA	AK137432.1	None	C57BL/6J
mRNA	BC106189.1	AAI06190.1
mRNA	M84120.1	AAA37172.1	BALB/c