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    MYSM1 Myb-like, SWIRM and MPN domains 1 [ Homo sapiens ]

    Gene ID: 114803, updated on 11-May-2012

    Summary

    Official Symbol
    MYSM1provided by HGNC
    Official Full Name
    Myb-like, SWIRM and MPN domains 1provided by HGNC
    Primary source
    HGNC:29401
    See related
    Ensembl:ENSG00000162601; MIM:612176; Vega:OTTHUMG00000009533
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    2ADUB; 2A-DUB; RP4-592A1.1; KIAA1915; DKFZp779J1554; DKFZp779J1721

    Genomic context

    Location :
    1p32.1
    Sequence :
    Chromosome: 1; NC_000001.10 (59120411..59165747, complement)
    See MYSM1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene tumor-associated calcium signal transducer 2 Neighboring gene adenylate kinase 2 pseudogene 1 Neighboring gene uncharacterized LOC100131060 Neighboring gene jun proto-oncogene

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:125363 BioGRID:108237 EEF1A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:113934 HIST2H2AC    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:125363 BioGRID:109428 HNRNPH1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:109535 HSPA1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:114375 KAT2B    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:125363 BioGRID:110030 KIF11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:115688 PRMT5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:113869 RBM10    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:116457 STK38    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:123347 TUBB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125363 BioGRID:122532 WDR77    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    metallopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin thiolesterase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-specific protease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    histone deubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    chromatin remodeling complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    histone H2A deubiquitinase MYSM1
    Names
    histone H2A deubiquitinase MYSM1
    myb-like, SWIRM and MPN domain-containing protein 1
    NP_001078956.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001085487.2NP_001078956.1  histone H2A deubiquitinase MYSM1

      Status: PROVISIONAL

      Source sequence(s)
      AL035411, AL450024
      Consensus CDS
      CCDS41343.1
      UniProtKB/Swiss-Prot
      Q5VVJ2
      Related
      ENSP00000418734, OTTHUMP00000011131, ENST00000472487, OTTHUMT00000026343
      Conserved Domains (4) summary
      cd00167
      Location:120163
      Blast Score: 112
      SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
      cd08067
      Location:571753
      Blast Score: 751
      MPN_2A_DUB; Mov34/MPN/PAD-1 family: Histone H2A deubiquitinase
      smart00717
      Location:120164
      Blast Score: 122
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      pfam04433
      Location:382461
      Blast Score: 218
      SWIRM; SWIRM domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      59120411..59165747, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      57230623..57275921, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL035411.28 CAI21908.1
    genomic AL450024.17 CAH70737.1
    mRNA AB067502.1 BAB67808.1
    mRNA AK126835.1 BAG54377.1
    mRNA AK292919.1 BAF85608.1
    mRNA BC037536.1 None
    mRNA BX537912.1 CAD97896.1
    mRNA BX648168.1 None
    mRNA CR627323.1 CAH10370.1
    mRNA CR749450.1 CAH18287.1
    other-genetic BC167849.1 AAI67849.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5VVJ2.1 GenPept UniProtKB/Swiss-Prot:Q5VVJ2

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