My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein [ Homo sapiens ]

    Gene ID: 114609, updated on 19-May-2012
    Help top of page

    Summary

    Official Symbol
    TIRAPprovided by HGNC
    Official Full Name
    toll-interleukin 1 receptor (TIR) domain containing adaptor proteinprovided by HGNC
    Primary source
    HGNC:17192
    See related
    Ensembl:ENSG00000150455; MIM:606252; Vega:OTTHUMG00000140373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Mal; wyatt; BACTS1; FLJ42305
    Summary
    The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
    Help top of page

    Genomic context

    Location :
    11q24.2
    Sequence :
    Chromosome: 11; NC_000011.9 (126152982..126164828)
    See TIRAP in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene FAD-dependent oxidoreductase domain containing 1 Neighboring gene ribosomal protein L35a pseudogene 26 Neighboring gene decapping enzyme, scavenger Neighboring gene uncharacterized LOC399972 Neighboring gene ST3 beta-galactoside alpha-2,3-sialyltransferase 4

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Li S, et al. Immunity, 2011 Sep 23. PMID 21903422.
    2. Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection. Valkov E, et al. Proc Natl Acad Sci U S A, 2011 Sep 6. PMID 21873236.
    3. TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding. Sakaguchi M, et al. PLoS One, 2011. PMID 21829704.
    4. TIRAP Ser180Leu polymorphism is associated with Behcet's disease. Durrani O, et al. Rheumatology (Oxford), 2011 Oct. PMID 21705416.
    5. Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients. Zakeri S, et al. Malar J, 2011 Apr 4. PMID 21457584.

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. TIRAP S180L polymorphism is unlikely to substantially contribute to tuberculosis susceptibility (Meta-analysis)
      Title: Meta-analysis on the association of TIRAP S180L variant and tuberculosis susceptibility.
    2. Blocking of the function of TIRAP and MyD88 largely abrogated intracellular signaling from ligand-activated RAGE
      Title: TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding.
    3. TIRAP G286A (D96N) polymorphism is associated with susceptibility to tuberculosis.
      Title: Association of TIRAP (MAL) gene polymorhisms with susceptibility to tuberculosis in a Chinese population.
    4. TIRAP 180Leu was significantly associated with Behcet's disease in UK, but not Middle Eastern, patients.
      Title: TIRAP Ser180Leu polymorphism is associated with Behcet's disease.
    5. a molecular and structural basis for the role of MAL in TLR signaling and disease protection.
      Title: Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection.
    6. RA synovium showed abundant expression of TLR. RA synovitis tissue seems to be responsive to TLR ligands.
      Title: Expression of Toll-like receptors and their signaling pathways in rheumatoid synovitis.
    7. Comparison of the tirap S180L genotypes between patients with mild malaria and those healthy individuals showed that the frequency of heterozygosity was significantly higher in infected than non-infected individuals.
      Title: Genetic variation of TLR-4, TLR-9 and TIRAP genes in Iranian malaria patients.
    8. Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis
      Title: Genetic variations in MyD88 adaptor-like are associated with atopic dermatitis.
    9. Data demonstrate a key role for Mal in mediating TLR2 and TLR4 activation of CREB and induction of CREB-responsive genes including Il-10.
      Title: Mal mediates TLR-induced activation of CREB and expression of IL-10.
    10. TIRAP gene might be associated with susceptibility to sepsis-associated acute lung injury in the Han Chinese population.
      Title: Genetic variants in the TIRAP gene are associated with increased risk of sepsis-associated acute lung injury.
    Submit: New GeneRIF Correction See all (46)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Bacteremia, protection against

    Malaria, protection against

    Pneumococcal disease, invasive, protection against

    Tuberculosis, protection against

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    P58753 Q06187 BTK    HPRD  PubMed  
    P58753 P20963 CD247    HPRD  PubMed  
    P58753 Q13217 DNAJC3    HPRD  PubMed  
    P58753 P19525 EIF2AK2    HPRD  PubMed  
    P58753 Q01638 IL1RL1    HPRD  PubMed  
    P58753 O43187 IRAK2    HPRD  PubMed  
    P58753 Q99836 MYD88    HPRD  PubMed  
    P58753 O75569 PRKRA    HPRD  PubMed  
    P58753 O15524 SOCS1    HPRD  PubMed  
    P58753 Toll-like receptor adaptor molecule 1 TICAM1    HPRD  PubMed  
    P58753 Toll like receptor adaptor molecule 2 TICAM2    HPRD  PubMed  
    P58753 O00206 TLR4    HPRD  PubMed  
    P58753 Q9Y4K3 TRAF6    HPRD  PubMed  
    P58753 Q15629 TRAM1    HPRD  PubMed  
    BioGRID:125325 BioGRID:106864 ARAF    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:125325 BioGRID:107284 CASP1    BioGRID  PubMed Biochemical Activity 
    BioGRID:125325 BioGRID:121318 CCDC47    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:125325 BioGRID:109771 IL1RAP    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:125325 BioGRID:109863 IRAK1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:125325 BioGRID:109865 IRAK2    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:125325 BioGRID:119322 IRAK4    BioGRID  PubMed Affinity Capture-MS; PCA; Reconstituted Complex 
    BioGRID:125325 BioGRID:109919 JAK1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125325 BioGRID:117509 LTN1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:125325 BioGRID:112748 MAP3K7    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:125325 BioGRID:110700 MYD88    BioGRID  PubMed Affinity Capture-Western; PCA; Phenotypic Suppression; Two-hybrid 
    BioGRID:125325 BioGRID:110836 NF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125325 BioGRID:116848 PDS5A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125325 BioGRID:119981 RNF216    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:125325 BioGRID:121582 RPTOR    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125325 BioGRID:117436 SAMHD1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:125325 BioGRID:116661 SNRNP200    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125325 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125325 BioGRID:116740 TAB2    BioGRID  PubMed Affinity Capture-MS 
    NP_067681.1 TICAM2    BIND  PubMed TIRP interacts with TIRAP. 
    BioGRID:125325 BioGRID:125325 TIRAP    BioGRID  PubMed Two-hybrid 
    BioGRID:125325 BioGRID:112952 TLR2    BioGRID  PubMed PCA 
    BioGRID:125325 BioGRID:112954 TLR4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; PCA; Phenotypic Suppression; Reconstituted Complex 
    BioGRID:125325 BioGRID:113041 TRAF6    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:125325 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:125325 BioGRID:128238 UBR1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125325 BioGRID:116896 UBR2    BioGRID  PubMed Affinity Capture-MS 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Activated TLR4 signalling, organism-specific biosystem (from REACTOME)
      Activated TLR4 signalling, organism-specific biosystemTLR4 is unique among the TLR family in its ability to recruit four adapters to activate two distinct signaling pathways. One pathway is activated by the pair of the adapters Mal or TIRAP (Toll/inter...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Innate Immune System, organism-specific biosystem (from REACTOME)
      Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
    • MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem (from REACTOME)
      MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystemThe first known downstream component of TLR4 and TLR2 signaling is the adaptor MyD88. Another adapter MyD88-adaptor-like (Mal; also known as TIR-domain-containing adaptor protein or TIRAP) has also b...
    • Pertussis, organism-specific biosystem (from KEGG)
      Pertussis, organism-specific biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Pertussis, conserved biosystem (from KEGG)
      Pertussis, conserved biosystemPertussis, also known as whooping cough, is an acute respiratory infectious disease caused by a bacteria called Bordetella Pertussis. The characteristic symptoms are paroxysmal cough, inspiratory whe...
    • Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystemTLR2 is involved in recognition of peptidoglycan from gram-positive bacteria, bacterial lipoproteins, mycoplasma lipoprotein and mycobacterial products. It is quite possible that recognition of at le...
    • Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor 4 (TLR4) Cascade, organism-specific biosystemToll-like Receptor 4 is a Microbe Associated Molecular Pattern receptor well known for it's sensitivity to Bacterial Lipopolysaccharides (LPS). LPS is assembled within diverse Gram-negative bacteria,...
    • Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR1:TLR2 Cascade, organism-specific biosystemTLR1 is expressed by monocytes. TLR1 and TLR2 cotranslationally form heterodimeric complexes on the cell surface and in the cytosol. The TLR2:TLR1 complex recognizes Neisserial PorB and Mycobacterial...
    • Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystem (from REACTOME)
      Toll Like Receptor TLR6:TLR2 Cascade, organism-specific biosystemTLR2 and TLR4 recognize different bacterial cell wall components. While TLR4 is trained onto Gram-negative lipopolysaccharide components, TLR2 - in combination with TLR6 - plays a major role in recog...
    • Toll Receptor Cascades, organism-specific biosystem (from REACTOME)
      Toll Receptor Cascades, organism-specific biosystemIn human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) doma...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from KEGG)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
      Toll-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Toll-like receptor signaling pathway, conserved biosystem (from KEGG)
      Toll-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors id...
    • Tuberculosis, organism-specific biosystem (from KEGG)
      Tuberculosis, organism-specific biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...
    • Tuberculosis, conserved biosystem (from KEGG)
      Tuberculosis, conserved biosystemTuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    Toll-like receptor 2 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Toll-like receptor 4 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    phosphatidylinositol-4,5-bisphosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding, bridging NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein heterodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    3'-UTR-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    MyD88-dependent toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    TIRAP-dependent toll-like receptor 4 signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Toll signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    cell surface receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cellular response to bacterial lipopeptide ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    cellular response to lipoteichoic acid ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    innate immune response TAS
    Traceable Author Statement
    more info
    		  
    myeloid cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    negative regulation of growth of symbiont in host ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of B cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of NF-kappaB transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of chemokine (C-X-C motif) ligand 1 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of chemokine (C-X-C motif) ligand 2 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of interleukin-12 production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of interleukin-15 production IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of interleukin-6 biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of interleukin-8 production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of neutrophil chemotaxis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of toll-like receptor 2 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of toll-like receptor 3 signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    positive regulation of toll-like receptor 4 signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    positive regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    regulation of innate immune response IC
    Inferred by Curator
    more info
    		 PubMed 
    regulation of interferon-beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    toll-like receptor 1 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 2 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor 4 signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    toll-like receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    endocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    intracellular IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    toll/interleukin-1 receptor domain-containing adapter protein
    Names
    toll/interleukin-1 receptor domain-containing adapter protein
    adapter protein wyatt
    adaptor protein Wyatt
    MyD88 adapter-like protein
    Toll-like receptor adaptor protein
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011523.1 RefSeqGene

      Range
      5001..16847
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001039661.1 → NP_001034750.1  toll/interleukin-1 receptor domain-containing adapter protein isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) represents the longer transcript but encodes the shorter isoform (a).
      Source sequence(s)
      AK124298, AP001318, BC032474
      Consensus CDS
      CCDS8472.1
      UniProtKB/Swiss-Prot
      P58753
      Related
      ENSP00000376447, OTTHUMP00000179131, ENST00000392680, OTTHUMT00000277092
      Conserved Domains (1) summary
      cl15770
      Location:88 – 198
      Blast Score: 128
      TIR_2; TIR domain

    2. NM_148910.2 → NP_683708.1  toll/interleukin-1 receptor domain-containing adapter protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an additional segment within the 5' UTR and differs in the 3' coding region and 3' UTR, compared to variant 3. This results in a longer isoform (b) with a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AF378129, AK124298
      Consensus CDS
      CCDS41731.1
      UniProtKB/Swiss-Prot
      P58753
      Related
      ENSP00000376445, OTTHUMP00000179132, ENST00000392678, OTTHUMT00000277093
      Conserved Domains (1) summary
      cl15770
      Location:88 – 198
      Blast Score: 128
      TIR_2; TIR domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      126152982..126164828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      122098046..122109916
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_052887.2: Suppressed sequence

      Description
      NM_052887.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AP001318.6 (55377..69848) None
    genomic AY282416.1 AAP31973.1
    genomic CH471065.1 EAW67687.1
      EAW67688.1
      EAW67689.1
    mRNA AB446477.1 BAG55254.1
    mRNA AF378129.1 AAL05627.1
    mRNA AF406652.1 AAL01160.1
    mRNA AF410783.1 AAL05036.1
    mRNA AK124298.1 BAG54027.1
    mRNA AK313147.1 BAG35965.1
    mRNA AY576785.1 AAT90417.1
    mRNA AY576786.1 AAT90418.1
    mRNA AY576787.1 AAT90419.1
    mRNA BC032474.1 AAH32474.1
    other-genetic DQ890988.2 ABM81914.1
    other-genetic DQ894164.2 ABM85090.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P58753.2 GenPept UniProtKB/Swiss-Prot:P58753
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...