bcl2l1 bcl2-like 1 [Danio rerio (zebrafish)] - Gene

Summary

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Official Symbol: bcl2l1provided by ZNC
Official Full Name: bcl2-like 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-010730-1
See related: Ensembl:ENSDARG00000008434; Vega:OTTDARG00000028128
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Danio
Also known as: blp1; bcl2l; cb1021; zfBLP1

Genomic context

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Location :: chromosome: 23

Sequence :: Chromosome: 23; NC_007134.5 (19242420..19270074, complement)

See bcl2l1 in MapViewer

Chromosome 23 - NC_007134.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

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Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
Title: Zebrafish anti-apoptotic gene Bcl-xL can prevent aquatic birnavirus-induced cell death in fish cells without affecting expression of viral proteins.
Delta113p53 functions to antagonize p53-induced apoptosis via activating bcl2L
Title: p53 isoform delta113p53 is a p53 target gene that antagonizes p53 apoptotic activity via BclxL activation in zebrafish.
Bcl-xL can block post-apoptotic necrosis processes thereby rescuing betanodavirus-infected cells
Title: Zebrafish anti-apoptotic protein zfBcl-xL can block betanodavirus protein alpha-induced mitochondria-mediated secondary necrosis cell death.
transgenic overexpression of zfBLP1 or myeloid cell leukemia sequence 1a in zebrafish larvae interrupts regulation of the homeostatic balance between cell proliferation and programmed cell death during hepatogenesis and leads to liver hyperplasia
Title: Imbalance in liver homeostasis leading to hyperplasia by overexpressing either one of the Bcl-2-related genes, zfBLP1 and zfMcl-1a.

Submit: New GeneRIF Correction

Pathways from BioSystems

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Apoptosis, organism-specific biosystem (from KEGG)
Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, conserved biosystem (from KEGG)
Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, organism-specific biosystem (from REACTOME)
Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Inflammasomes, organism-specific biosystem (from REACTOME)
Inflammasomes, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
Intrinsic Pathway for Apoptosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Jak-STAT signaling pathway, conserved biosystem (from KEGG)
Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemcomputationally inferred pathway (not manually curated)
The NLRP1 inflammasome, organism-specific biosystem (from REACTOME)
The NLRP1 inflammasome, organism-specific biosystemcomputationally inferred pathway (not manually curated)

General gene information

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Homology

Homologs of the bcl2l1 gene: The bcl2l1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken.
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info
regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
thyroid gland development	IMP Inferred from Mutant Phenotype more info
tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: bcl-2-like protein 1

Names: bcl-2-like protein 1; bcl-XL; Bcl-xL-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131807.1 → NP_571882.1 bcl-2-like protein 1

Status: PROVISIONAL

Source sequence(s)

AF317837

UniProtKB/TrEMBL

Q90Z98

Related

ENSDARP00000119990, OTTDARP00000030594, ENSDART00000147617, OTTDART00000038166

Conserved Domains (3) summary

cd06845
Location:82 – 196
Blast Score: 394

Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

pfam02180
Location:1 – 27
Blast Score: 127

BH4; Bcl-2 homology region 4

TIGR00865
Location:88 – 221
Blast Score: 518

bcl-2; apoptosis regulator

RefSeqs of Annotated Genomes: Build 5.1

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Zv9 Primary Assembly

Genomic

NC_007134.5 Reference Zv9 Primary Assembly

Range

19242420..19270074, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CR788311.7 (29939..57593)	None
mRNA	AF317837.1	AAK81706.1
mRNA	BC044130.1	AAH44130.1	AB
mRNA	BC071291.1	AAH71291.1
mRNA	BC165156.1	AAI65156.1
mRNA	DQ022560.1	AAY43152.1	AB