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Chrna1 cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle) [ Mus musculus (house mouse) ]

Gene ID: 11435, updated on 28-May-2016
Official Symbol
Chrna1provided by MGI
Official Full Name
cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)provided by MGI
Primary source
MGI:MGI:87885
See related
Ensembl:ENSMUSG00000027107 Vega:OTTMUSG00000013434
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acra; Achr-1; AI385656; AI608266
Summary
This gene encodes an alpha subunit of the muscle-derived nicotinic acetylcholine receptor, a pentameric neurotransmitter receptor and member of the ligand-gated ion channel superfamily. The alpha subunit plays a role in substrate binding and channel gating. [provided by RefSeq, Nov 2012]
Orthologs
Location:
2 C3; 2 43.76 cM
Exon count:
9
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (73563281..73580338, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (73401338..73418363, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13707 Neighboring gene WAS/WASL interacting protein family, member 1 Neighboring gene predicted gene, 30640 Neighboring gene predicted gene, 30940 Neighboring gene predicted gene, 31264 Neighboring gene chimerin 1, opposite strand 3 Neighboring gene chimerin 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to acetylcholine binding IGI
Inferred from Genetic Interaction
more info
PubMed 
contributes_to acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to acetylcholine-activated cation-selective channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acetylcholine-activated cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
 
extracellular ligand-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cation transport ISO
Inferred from Sequence Orthology
more info
 
ion transport IEA
Inferred from Electronic Annotation
more info
 
muscle cell cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
musculoskeletal movement ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction development ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process ISO
Inferred from Sequence Orthology
more info
 
neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
neuromuscular synaptic transmission ISO
Inferred from Sequence Orthology
more info
 
neuron cellular homeostasis ISO
Inferred from Sequence Orthology
more info
 
neuronal action potential ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of membrane potential ISO
Inferred from Sequence Orthology
more info
 
response to nicotine IBA
Inferred from Biological aspect of Ancestor
more info
 
skeletal muscle contraction ISO
Inferred from Sequence Orthology
more info
 
skeletal muscle tissue growth ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission, cholinergic IBA
Inferred from Biological aspect of Ancestor
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
acetylcholine-gated channel complex IPI
Inferred from Physical Interaction
more info
PubMed 
acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
cell ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
acetylcholine receptor subunit alpha

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007389.5NP_031415.2  acetylcholine receptor subunit alpha precursor

    See identical proteins and their annotated locations for NP_031415.2

    Status: REVIEWED

    Source sequence(s)
    AK029177, AL928813, AL928889
    Consensus CDS
    CCDS16132.1
    UniProtKB/Swiss-Prot
    P04756
    UniProtKB/TrEMBL
    Q05A24
    Related
    ENSMUSP00000028515, OTTMUSP00000014418, ENSMUST00000028515, OTTMUST00000032468
    Conserved Domains (3) summary
    pfam02931
    Location:24231
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:238446
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    TIGR00860
    Location:21447
    LIC; Cation transporter family protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    73563281..73580338 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    75249906..75266945 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)