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Chek2 checkpoint kinase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114212, updated on 26-May-2016
Official Symbol
Chek2provided by RGD
Official Full Name
checkpoint kinase 2provided by RGD
Primary source
RGD:621543
See related
Ensembl:ENSRNOG00000037509
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Chk2; Rad53
Summary
kinase involved in ATM-dependent DNA damage checkpoint pathway [RGD, Feb 2006]
Orthologs
Location:
12q16
Exon count:
16
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (51845574..51878097, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (53583932..53616450, complement)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene uncharacterized LOC102553196 Neighboring gene uncharacterized LOC103691463 Neighboring gene HscB mitochondrial iron-sulfur cluster co-chaperone Neighboring gene unc-51 like autophagy activating kinase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA damage induced protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
DNA damage induced protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
G2/M transition of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
apoptotic process ISO
Inferred from Sequence Orthology
more info
 
cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
cellular protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to bisphenol A IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to drug IEP
Inferred from Expression Pattern
more info
PubMed 
double-strand break repair IEA
Inferred from Electronic Annotation
more info
 
double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
mitotic spindle assembly IEA
Inferred from Electronic Annotation
more info
 
mitotic spindle assembly ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell cycle arrest IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of anoikis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IEA
Inferred from Electronic Annotation
more info
 
protein stabilization ISO
Inferred from Sequence Orthology
more info
 
regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
replicative cell aging IEA
Inferred from Electronic Annotation
more info
 
replicative cell aging ISO
Inferred from Sequence Orthology
more info
 
response to gamma radiation IEA
Inferred from Electronic Annotation
more info
 
response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
signal transduction involved in intra-S DNA damage checkpoint IEA
Inferred from Electronic Annotation
more info
 
signal transduction involved in intra-S DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
PML body IEA
Inferred from Electronic Annotation
more info
 
PML body ISO
Inferred from Sequence Orthology
more info
 
chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
serine/threonine-protein kinase Chk2
Names
CHK2 checkpoint homolog
protein kinase Chk2
NP_446129.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053677.1NP_446129.1  serine/threonine-protein kinase Chk2

    See identical proteins and their annotated locations for NP_446129.1

    Status: PROVISIONAL

    Source sequence(s)
    AF134054
    UniProtKB/TrEMBL
    Q9R019
    Related
    ENSRNOP00000053643, ENSRNOT00000056800
    Conserved Domains (3) summary
    smart00220
    Location:223489
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:96204
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:216489
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    51845574..51878097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249521.2XP_006249583.1  

    See identical proteins and their annotated locations for XP_006249583.1

    UniProtKB/TrEMBL
    Q9R019
    Related
    ENSRNOP00000074651, ENSRNOT00000085591
    Conserved Domains (3) summary
    smart00220
    Location:223489
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:96204
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:216489
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
  2. XM_006249520.2XP_006249582.1  

    See identical proteins and their annotated locations for XP_006249582.1

    UniProtKB/TrEMBL
    Q9R019
    Conserved Domains (3) summary
    smart00220
    Location:223489
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:96204
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:216489
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
  3. XM_006249519.2XP_006249581.1  

    See identical proteins and their annotated locations for XP_006249581.1

    UniProtKB/TrEMBL
    Q9R019
    Conserved Domains (3) summary
    smart00220
    Location:223489
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:96204
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:216489
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
  4. XM_006249518.2XP_006249580.1  

    See identical proteins and their annotated locations for XP_006249580.1

    UniProtKB/TrEMBL
    Q9R019
    Conserved Domains (3) summary
    smart00220
    Location:223489
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:96204
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:216489
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2
  5. XM_008769308.1XP_008767530.1  

    Conserved Domains (3) summary
    smart00220
    Location:223464
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00060
    Location:96204
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
    cd14084
    Location:216464
    STKc_Chk2; Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    47348969..47380486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)