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Sh2b2 SH2B adaptor protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114203, updated on 17-May-2016
Official Symbol
Sh2b2provided by RGD
Official Full Name
SH2B adaptor protein 2provided by RGD
Primary source
RGD:69284
See related
Ensembl:ENSRNOG00000001425
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Aps
Summary
plays a role in Trk mediated signalling during neurogenesis [RGD, Feb 2006]
Orthologs
Location:
12q12
Exon count:
11
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (23471244..23501043)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (25472225..25501387)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene myosin light chain 10 Neighboring gene cut-like homeobox 1 Neighboring gene Prkr interacting protein 1 (IL11 inducible) Neighboring gene ORAI calcium release-activated calcium modulator 2

  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ???? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation...
  • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-5 Signaling Pathway, organism-specific biosystem
    IL-5 Signaling Pathway
  • Insulin Signaling, organism-specific biosystem (from WikiPathways)
    Insulin Signaling, organism-specific biosystem
    Insulin Signaling
  • Insulin signaling pathway, organism-specific biosystem (from KEGG)
    Insulin signaling pathway, organism-specific biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Insulin signaling pathway, conserved biosystem (from KEGG)
    Insulin signaling pathway, conserved biosystemInsulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase (INSR). This allows association of IRSs with the r...
  • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
JAK pathway signal transduction adaptor activity ISO
Inferred from Sequence Orthology
more info
 
SH3/SH2 adaptor activity IEA
Inferred from Electronic Annotation
more info
 
SH3/SH2 adaptor activity ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase adaptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B-1 B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
B-1 B cell homeostasis ISO
Inferred from Sequence Orthology
more info
 
actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
antigen receptor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
antigen receptor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
brown fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
brown fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
 
regulation of Ras protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune response ISO
Inferred from Sequence Orthology
more info
 
regulation of metabolic process IEA
Inferred from Electronic Annotation
more info
 
regulation of metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
actin filament IEA
Inferred from Electronic Annotation
more info
 
actin filament ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
ruffle IEA
Inferred from Electronic Annotation
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
stress fiber IEA
Inferred from Electronic Annotation
more info
 
stress fiber ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
SH2B adapter protein 2
Names
SH2 and PH domain-containing adapter protein APS
adapter protein with pleckstrin homology and Src homology 2 domains
adaptor protein with pleckstrin homology and src homology 2 domains

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053669.1NP_446121.1  SH2B adapter protein 2

    See identical proteins and their annotated locations for NP_446121.1

    Status: PROVISIONAL

    Source sequence(s)
    AF095576
    UniProtKB/Swiss-Prot
    Q9Z200
    Related
    ENSRNOP00000001935, ENSRNOT00000001935
    Conserved Domains (4) summary
    pfam08916
    Location:1674
    Phe_ZIP; Phenylalanine zipper
    cd10411
    Location:401496
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:186301
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    cl00807
    Location:149172
    MNHE; Na+/H+ ion antiporter subunit

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    23471244..23501043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249093.2XP_006249155.1  

    Conserved Domains (4) summary
    pfam08916
    Location:50108
    Phe_ZIP; Phenylalanine zipper
    cd10411
    Location:434529
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:220335
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    cl00807
    Location:183206
    MNHE; Na+/H+ ion antiporter subunit
  2. XM_006249092.2XP_006249154.1  

    See identical proteins and their annotated locations for XP_006249154.1

    Conserved Domains (4) summary
    pfam08916
    Location:50108
    Phe_ZIP; Phenylalanine zipper
    cd10411
    Location:435530
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:220335
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    cl00807
    Location:183206
    MNHE; Na+/H+ ion antiporter subunit
  3. XM_008769112.1XP_008767334.1  

    See identical proteins and their annotated locations for XP_008767334.1

    Conserved Domains (4) summary
    pfam08916
    Location:50108
    Phe_ZIP; Phenylalanine zipper
    cd10411
    Location:435530
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:220335
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    cl00807
    Location:183206
    MNHE; Na+/H+ ion antiporter subunit
  4. XM_008769113.1XP_008767335.1  

    See identical proteins and their annotated locations for XP_008767335.1

    UniProtKB/Swiss-Prot
    Q9Z200
    Conserved Domains (4) summary
    pfam08916
    Location:1674
    Phe_ZIP; Phenylalanine zipper
    cd10411
    Location:401496
    SH2_SH2B2; Src homology 2 (SH2) domain found in SH2B adapter proteins (SH2B1, SH2B2, SH2B3)
    cd01231
    Location:186301
    PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain
    cl00807
    Location:149172
    MNHE; Na+/H+ ion antiporter subunit

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    22198080..22225866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)