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Cxcl2 C-X-C motif chemokine ligand 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114105, updated on 17-May-2016
Official Symbol
Cxcl2provided by RGD
Official Full Name
C-X-C motif chemokine ligand 2provided by RGD
Primary source
RGD:70069
See related
Ensembl:ENSRNOG00000002792
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Mip-2; Scyb2
Summary
chemokine involved in the pulmonary inflammatory response [RGD, Feb 2006]
Location:
14p22
Exon count:
4
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (18731346..18733391, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 14 NC_005113.3 (18640312..18642357, complement)

Chromosome 14 - NC_005113.4Genomic Context describing neighboring genes Neighboring gene epithelial mitogen Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like Neighboring gene chemokine (C-X-C motif) ligand 1 Neighboring gene uncharacterized LOC102548839

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
    Chemokine receptors bind chemokines, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
    Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Chemokine signaling pathway, conserved biosystem (from KEGG)
    Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Legionellosis, organism-specific biosystem (from KEGG)
    Legionellosis, organism-specific biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • Legionellosis, conserved biosystem (from KEGG)
    Legionellosis, conserved biosystemLegionellosis is a potentially fatal infectious disease caused by the bacterium Legionella pneumophila and other legionella species. Two distinct clinical and epidemiological syndromes are associated...
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • PI3K_AKT_NFKB pathway, organism-specific biosystem (from WikiPathways)
    PI3K_AKT_NFKB pathway, organism-specific biosystemNFKB is an important transcription factor induced by multiple cellular mechanisms. This pathway diagram depicts the major activators of the pathway and the downsteam genes regulated by the pathway. A...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Salmonella infection, organism-specific biosystem (from KEGG)
    Salmonella infection, organism-specific biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Salmonella infection, conserved biosystem (from KEGG)
    Salmonella infection, conserved biosystemSalmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, S...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • TNF signaling pathway, organism-specific biosystem (from KEGG)
    TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
  • TNF signaling pathway, conserved biosystem (from KEGG)
    TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
CXCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
chemokine activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
cellular response to interleukin-1 IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to lipopolysaccharide IEP
Inferred from Expression Pattern
more info
PubMed 
chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
leukocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron death IDA
Inferred from Direct Assay
more info
PubMed 
neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
response to amphetamine IEP
Inferred from Expression Pattern
more info
PubMed 
response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
response to gamma radiation IEP
Inferred from Expression Pattern
more info
PubMed 
response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
response to heat IEP
Inferred from Expression Pattern
more info
PubMed 
response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
 
wound healing IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
cell IEA
Inferred from Electronic Annotation
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
C-X-C motif chemokine 2
Names
CINC-3
MIP2
chemokine (C-X-C motif) ligand 2
cytokine-induced neutrophil chemoattractant 3
macrophage inflammatory protein 2
small inducible cytokine subfamily, member 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053647.1NP_446099.1  C-X-C motif chemokine 2 precursor

    See identical proteins and their annotated locations for NP_446099.1

    Status: PROVISIONAL

    Source sequence(s)
    AB060092
    UniProtKB/Swiss-Prot
    P30348
    Related
    ENSRNOP00000003745, ENSRNOT00000003745
    Conserved Domains (1) summary
    cd00273
    Location:3395
    Chemokine_CXC; Chemokine_CXC: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005113.4 Reference Rnor_6.0 Primary Assembly

    Range
    18731346..18733391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000082.1 Alternate Rn_Celera

    Range
    16558112..16560157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)