Sqstm1 sequestosome 1 [Rattus norvegicus] - Gene

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Summary

Official Symbol: Sqstm1provided by RGD
Official Full Name: sequestosome 1provided by RGD
Primary source: RGD:69287
See related: Ensembl:ENSRNOG00000003147
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as: Osi; ZIP; ZIP3
Summary: interacts with PKC-zeta and GABA(C) receptors to form ternary postsynaptic complex in the retina [RGD, Feb 2006]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly

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Genomic context

Location :: 10q21

Sequence :: Chromosome: 10; NC_005109.2 (35751300..35762630, complement)

See Sqstm1 in MapViewer

Chromosome 10 - NC_005109.2 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the function of p62/SQSTM1 in the proteasomal pathway and autophagy
Title: Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.
The scaffold protein p62 that delivers polyubiquitinated proteins to autophagy may have a protective role against human-IAPP-induced apoptosis.
Title: Human-IAPP disrupts the autophagy/lysosomal pathway in pancreatic β-cells: protective role of p62-positive cytoplasmic inclusions.
Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
Title: Zymophagy, a novel selective autophagy pathway mediated by VMP1-USP9x-p62, prevents pancreatic cell death.
Data show that p38 activation induces PPARalpha phosphorylation and inhibition of its transcriptional activity through a trimeric interaction between p38-MAPK, ZIP/p62 and PPARalpha.
Title: Involvement of ZIP/p62 in the regulation of PPARalpha transcriptional activity by p38-MAPK.
p62 regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
Title: The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination.

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_787037.2	NP_058999.1	Kcnab1	BIND	PubMed	ZIP1 interacts with Kv-beta-1.
NP_787037.2	NP_059000.1	Kcnab2	BIND	PubMed	ZIP1 interacts with Kv-beta-2.
NP_787037.2	XP_220926.2	Nbr1	BIND	PubMed	p62 interacts with nbr1.
NP_787037.2	NP_071952.1	Prkcz	BIND	PubMed	The amino terminus of PKC-zeta, which contains a pseudosubstrate region, interacts with the amino terminus of ZIP, which contains a Cdc24 homology motif. PKC-zeta phosphorylates ZIP.
NP_787037.2	NP_787037.2	Sqstm1	BIND	PubMed	p62 interacts with p62.
NP_787037.2	NP_787037.2	Sqstm1	BIND	PubMed	ZIP forms a homodimer.
NP_787037.2	NP_543179.1	Trim63	BIND	PubMed	p62 interacts with MuRF2.
NP_853528.1	NP_058987.1	Gabrr1	BIND	PubMed	ZIP3 interacts with rho-1.
NP_853528.1	NP_058988.1	Gabrr2	BIND	PubMed	ZIP3 interacts with rho-2.
NP_853528.1	NP_620252.1	Gabrr3	BIND	PubMed	ZIP3 interacts with rho-3.
NP_853528.1	NP_059000.1	Kcnab2	BIND	PubMed	ZIP3 interacts with Kv-beta-2.
NP_853528.1	NP_071952.1	Prkcz	BIND	PubMed	ZIP3 interacts with PKC-zeta.
NP_853528.1	NP_787037.2	Sqstm1	BIND	PubMed	ZIP3 interacts with ZIP1.
NP_853528.1	NP_853528.1	Sqstm1	BIND	PubMed	ZIP3 interacts with a second ZIP3 molecule.
NP_853528.1		Sqstm1	BIND	PubMed	ZIP3 interacts with ZIP2.
BioGRID:250206	BioGRID:251384	Gabrr3	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
	NP_058999.1	Kcnab1	BIND	PubMed	ZIP2 interacts with Kv-beta-1.
	NP_059000.1	Kcnab2	BIND	PubMed	ZIP2 interacts with Kv-beta-2.
BioGRID:250206	BioGRID:248350	Kcnab2	BioGRID	PubMed	Reconstituted Complex
BioGRID:250206	BioGRID:248731	Ntrk1	BioGRID	PubMed	Affinity Capture-Western
	NP_071952.1	Prkcz	BIND	PubMed	PKC-zeta interacts with ZIP2.
BioGRID:250206	BioGRID:247554	Prkcz	BioGRID	PubMed	Reconstituted Complex
BioGRID:250206	BioGRID:250996	Slc40a1	BioGRID	PubMed	Reconstituted Complex
	NP_787037.2	Sqstm1	BIND	PubMed	ZIP2 interacts with ZIP1.
BioGRID:250206	BioGRID:250206	Sqstm1	BioGRID	PubMed	Reconstituted Complex
BioGRID:250206	BioGRID:257478	Traf4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:250206	BioGRID:259875	Traf6	BioGRID	PubMed	Affinity Capture-Western
BioGRID:250206	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western
BioGRID:250206	BioGRID:258978	Zfp110	BioGRID	PubMed	Affinity Capture-Western

Function	Evidence Code	Pubs
K63-linked polyubiquitin binding	ISO Inferred from Sequence Orthology more info
SH2 domain binding	ISO Inferred from Sequence Orthology more info
SH2 domain binding	ISS Inferred from Sequence or Structural Similarity more info
identical protein binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase C binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase C binding	ISO Inferred from Sequence Orthology more info
protein kinase C binding	ISS Inferred from Sequence or Structural Similarity more info
protein kinase binding	ISO Inferred from Sequence Orthology more info
ubiquitin binding	ISO Inferred from Sequence Orthology more info
ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
apoptotic process	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
macroautophagy	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein heterooligomerization	IPI Inferred from Physical Interaction more info	PubMed
regulation of I-kappaB kinase/NF-kappaB cascade	ISO Inferred from Sequence Orthology more info
regulation of I-kappaB kinase/NF-kappaB cascade	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
cellular_component	ND No biological Data available more info
cytoplasm	IEA Inferred from Electronic Annotation more info
late endosome	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: sequestosome-1

Names: sequestosome-1; oxidative stress induced; PKC-zeta-interacting protein; ubiquitin-binding protein p62; protein kinase C-zeta-interacting protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175843.3 → NP_787037.2 sequestosome-1 isoform 1

Status: PROVISIONAL

Source sequence(s)

BC061575

UniProtKB/Swiss-Prot

O08623

Related

ENSRNOP00000056021, ENSRNOT00000059255

Conserved Domains (3) summary

cd02340
Location:123 – 163
Blast Score: 203

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd06402
Location:4 – 100
Blast Score: 321

PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...

cl00153
Location:393 – 430
Blast Score: 100

UBA; Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been ...
NM_181550.1 → NP_853528.1 sequestosome-1 isoform 2

Status: PROVISIONAL

Source sequence(s)

AF439403

UniProtKB/Swiss-Prot

O08623

Conserved Domains (2) summary

cd02340
Location:123 – 163
Blast Score: 178

ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...

cd06402
Location:4 – 100
Blast Score: 320

PB1_p62; The PB1 domain is an essential part of p62 scaffold protein (alias sequestosome 1,SQSTM) involved in cell signaling, receptor internalization, and protein turnover. The PB1 domain is a modular domain mediating specific protein-protein interaction which ...

RefSeqs of Annotated Genomes: Build 4.2

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly (based on RGSC_v3.4)

Genomic

NC_005109.2 Reference assembly (based on RGSC_v3.4)

Range

35751300..35762630, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate assembly (Rn_Celera)

Genomic

AC_000078.1 Alternate assembly (Rn_Celera)

Range

33874680..33885832, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	CH473948.1	EDM04255.1
		EDM04256.1
		EDM04257.1
		EDM04258.1
mRNA	AF053095.1	AAC28626.1	Sprague-Dawley
mRNA	AF439403.1	AAO15463.1	Sprague-Dawley
mRNA	BC061575.1	AAH61575.1
mRNA	Y08355.1	CAA69642.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
O08622	GenPept	UniProtKB/TrEMBL:O08622
O08623.1	GenPept	UniProtKB/Swiss-Prot:O08623
O88434	GenPept	UniProtKB/TrEMBL:O88434