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SDSL serine dehydratase like [ Homo sapiens (human) ]

Gene ID: 113675, updated on 8-May-2016
Official Symbol
SDSLprovided by HGNC
Official Full Name
serine dehydratase likeprovided by HGNC
Primary source
HGNC:HGNC:30404
See related
Ensembl:ENSG00000139410 HPRD:11542; Vega:OTTHUMG00000169551
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TDH; cSDH; SDH 2; SDS-RS1
Orthologs
Location:
12q24.13
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (113422268..113438277)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (113860042..113876081)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369989 Neighboring gene phospholipase B domain containing 2 Neighboring gene serine dehydratase Neighboring gene LHX5 antisense RNA 1 (head to head) Neighboring gene LIM homeobox 5 Neighboring gene uncharacterized LOC105369990

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Biosynthesis of amino acids, organism-specific biosystem (from KEGG)
    Biosynthesis of amino acids, organism-specific biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Biosynthesis of amino acids, conserved biosystem (from KEGG)
    Biosynthesis of amino acids, conserved biosystemThis map presents a modular architecture of the biosynthesis pathways of twenty amino acids, which may be viewed as consisting of the core part and its extensions. The core part is the KEGG module fo...
  • Carbon metabolism, organism-specific biosystem (from KEGG)
    Carbon metabolism, organism-specific biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Carbon metabolism, conserved biosystem (from KEGG)
    Carbon metabolism, conserved biosystemCarbon metabolism is the most basic aspect of life. This map presents an overall view of central carbon metabolism, where the number of carbons is shown for each compound denoted by a circle, excludi...
  • Cysteine and methionine metabolism, organism-specific biosystem (from KEGG)
    Cysteine and methionine metabolism, organism-specific biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Cysteine and methionine metabolism, conserved biosystem (from KEGG)
    Cysteine and methionine metabolism, conserved biosystemCysteine and methionine are sulfur-containing amino acids. Cysteine is synthesized from serine through different pathways in different organism groups. In bacteria and plants, cysteine is converted f...
  • Glycine, serine and threonine metabolism, organism-specific biosystem (from KEGG)
    Glycine, serine and threonine metabolism, organism-specific biosystemSerine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In ...
  • Glycine, serine and threonine metabolism, conserved biosystem (from KEGG)
    Glycine, serine and threonine metabolism, conserved biosystemSerine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In ...
  • L-serine degradation, organism-specific biosystem (from BIOCYC)
    L-serine degradation, organism-specific biosystemBackground : SER, is a nonessential amino acid, in that it is synthesized in vivo. It can also be derived from dietary intake, protein degradation and phospholipid degradation. It is not only used ...
  • L-serine degradation, conserved biosystem (from BIOCYC)
    L-serine degradation, conserved biosystemThe L-serine degradation pathway consists of a single enzymatic reaction, catalyzed by |FRAME: EC-4.3.1.17|. The enzyme, which is |FRAME: PYRIDOXAL_PHOSPHATE|-dependent, dehydrates L-serine to the en...
  • L-threonine degradation V, conserved biosystem (from BIOCYC)
    L-threonine degradation V, conserved biosystemGeneral Background |FRAME: THR| is an indispensable amino acid and is degraded by two major degradative pathways in vertebrates. In most vertebrates, the degradation of L-threonine occurs through a ...
  • Metabolic pathways, organism-specific biosystem (from KEGG)
    Metabolic pathways, organism-specific biosystem
    Metabolic pathways
  • Valine, leucine and isoleucine biosynthesis, organism-specific biosystem (from KEGG)
    Valine, leucine and isoleucine biosynthesis, organism-specific biosystem
    Valine, leucine and isoleucine biosynthesis
  • Valine, leucine and isoleucine biosynthesis, conserved biosystem (from KEGG)
    Valine, leucine and isoleucine biosynthesis, conserved biosystem
    Valine, leucine and isoleucine biosynthesis
  • threonine degradation, organism-specific biosystem (from BIOCYC)
    threonine degradation, organism-specific biosystemGeneral Background : THR is an indispensable amino acid and is degraded by two major degradative pathways in vertebrates. In most vertebrates, the degradation of L-threonine occurs through a two-ste...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
 
L-threonine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
cellular amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serine dehydratase-like
Names
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase
serine dehydratase 2
serine dehydratase related sequence 1
NP_001291922.1
NP_612441.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304993.1NP_001291922.1  serine dehydratase-like

    See identical proteins and their annotated locations for NP_001291922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010178, BC091479
    Consensus CDS
    CCDS9170.1
    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0A024RBL2
    Related
    ENSP00000385790, OTTHUMP00000241522, ENST00000403593, OTTHUMT00000404782
    Conserved Domains (1) summary
    cl00342
    Location:17326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  2. NM_138432.3NP_612441.1  serine dehydratase-like

    See identical proteins and their annotated locations for NP_612441.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC010178, BC009849
    Consensus CDS
    CCDS9170.1
    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0A024RBL2
    Related
    ENSP00000341117, OTTHUMP00000241524, ENST00000345635, OTTHUMT00000404784
    Conserved Domains (1) summary
    cl00342
    Location:17326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    113422268..113438277
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537846.1XP_011536148.1  

    See identical proteins and their annotated locations for XP_011536148.1

    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0A024RBL2
    Conserved Domains (1) summary
    cl00342
    Location:17326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
  2. XM_005253831.3XP_005253888.1  

    See identical proteins and their annotated locations for XP_005253888.1

    UniProtKB/Swiss-Prot
    Q96GA7
    UniProtKB/TrEMBL
    A0A024RBL2
    Conserved Domains (1) summary
    cl00342
    Location:17326
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    113828413..113844299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)