Abl1 c-abl oncogene 1, non-receptor tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Abl1provided by MGI
Official Full Name: c-abl oncogene 1, non-receptor tyrosine kinaseprovided by MGI
Primary source: MGI:87859
Locus tag: RP23-65P13.3
See related: Ensembl:ENSMUSG00000026842; Vega:OTTMUSG00000012077
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Abl; c-Abl; AI325092; E430008G22Rik

Genomic context

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Location :: 2 B; 2 21.86 cM

Sequence :: Chromosome: 2; NC_000068.7 (31688556..31804227)

See Abl1 in Epigenomics, MapViewer

Chromosome 2 - NC_000068.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

The results of this study suggest that the interferon signaling pathway may play a role in the pathologic processes caused by c-Abl expression in neurons.
Title: Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways.
The results reveal a receptor-proximal switch mechanism by which Mig6 actively senses EGF deprivation to directly activate proapoptotic c-Abl.
Title: Mig6 is a sensor of EGF receptor inactivation that directly activates c-Abl to induce apoptosis during epithelial homeostasis.
tyrosine kinases of the Abl family are present in podosomes formed by murine and human macrophages.
Title: The tyrosine kinase Abl is a component of macrophage podosomes and is required for podosome formation and function.
Abl and Arg play complementary, nonredundant roles in the phagocytosis of opsonized beads and Leishmania
Title: The Abl and Arg kinases mediate distinct modes of phagocytosis and are required for maximal Leishmania infection.
Identify c-Abl as a regulator of bone morphogenetic protein signalling pathways and uncover a role for c-Abl in p16(INK4a) expression and osteoprogenitor expansion.
Title: c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression.
Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice.
Title: Essential role for telomerase in chronic myeloid leukemia induced by BCR-ABL in mice.
ABL1 regulates spindle orientation in adherent cells and mammalian skin
Title: ABL1 regulates spindle orientation in adherent cells and mammalian skin.
STAT5a/b is essential for the induction of CML-like leukemia by BCR-ABL1 and of polycythemia by JAK2(V617F).
Title: Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice.
the stage-specific protein pattern of the mammalian c-Abl tyrosine kinase presented a good correlation with the mouse estrus cycle and may have a regulative function during the uterine remodeling.
Title: The c-Abl expression in uterine epithelium during the mouse estrus cycle.
the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl
Title: c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr-218.

Submit: New GeneRIF Correction See all (86)

Alleles

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Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (Floxed/Frt) (4) 1 citation
Targeted (knock-out) (4) 1 citation
Targeted (knock-in) (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_033724.1	NP_033724.1	Abl1	BIND	PubMed	c-Abl undergoes autophosphorylation.
NP_033724.1	NP_071304.1	Cables1	BIND	PubMed	Cables interacts with the SH3 domain of c-Abl.
NP_033724.1	NP_665850.1	Cables2	BIND	PubMed	Ik3-2 interacts with c-Abl.
NP_033724.1	NP_034200.3	Dok1	BIND	PubMed	c-Abl interacts with Dok1.
NP_033724.1	AAC52863.1	Enah	BIND	PubMed	Mena interacts with Abl. This interaction was modelled on a demonstrated interaction between mouse Mena and Abl from an unspecified species.
NP_033724.1	NP_031991.2	Evl	BIND	PubMed	EVL interacts with Abl SH3 domain. This interaction was modeled on a demonstrated interaction between mouse EVL and Abl from an unspecified species.
NP_033724.1	NP_954711.1	Sema6d	BIND	PubMed	Sema6D interacts with Abl kinase.
BioGRID:197906	BioGRID:197906	Abl1	BioGRID	PubMed	Biochemical Activity
BioGRID:197906	BioGRID:211529	Asrgl1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:197906	BioGRID:198527	Cbl	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:197906	BioGRID:198717	Cish	BioGRID	PubMed	Affinity Capture-Western
BioGRID:197906	BioGRID:198887	Crk	BioGRID	PubMed	Affinity Capture-MS
BioGRID:197906	BioGRID:198888	Crkl	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:197906	BioGRID:199267	Dok1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:197906	BioGRID:205149	Dok3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:197906	BioGRID:109257	GZMB	BioGRID	PubMed	Biochemical Activity
BioGRID:197906	BioGRID:201466	Grap2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:197906	BioGRID:200769	Inpp5d	BioGRID	PubMed	Affinity Capture-Western
BioGRID:197906	BioGRID:201704	Nck1	BioGRID	PubMed	Reconstituted Complex
BioGRID:197906	BioGRID:206136	Park2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:197906	BioGRID:202477	Ptpn11	BioGRID	PubMed	Affinity Capture-Western
BioGRID:197906	BioGRID:202525	Pxn	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:197906	BioGRID:230435	Rin1	BioGRID	PubMed	Biochemical Activity; Reconstituted Complex

Pathways from BioSystems

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Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
Axon guidance, organism-specific biosystem (from KEGG)
Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, conserved biosystem (from KEGG)
Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
CDO in myogenesis, organism-specific biosystem (from REACTOME)
CDO in myogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Cell cycle, organism-specific biosystem (from KEGG)
Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle, organism-specific biosystem (from WikiPathways)
Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
Cell cycle, conserved biosystem (from KEGG)
Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
Cell cycle signaling pathway, organism-specific biosystem
Cell cycle signaling pathway
Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
Chronic myeloid leukemia, conserved biosystem (from KEGG)
Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
ErbB signaling pathway, organism-specific biosystem (from KEGG)
ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
ErbB signaling pathway, conserved biosystem (from KEGG)
ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
Factors involved in megakaryocyte development and platelet production, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystem (from REACTOME)
Fcgamma receptor (FCGR) dependent phagocytosis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Hemostasis, organism-specific biosystem (from REACTOME)
Hemostasis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
Myogenesis, organism-specific biosystem (from REACTOME)
Myogenesis, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Neurotrophin signaling pathway, conserved biosystem (from KEGG)
Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystem (from REACTOME)
Regulation of actin dynamics for phagocytic cup formation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
Role of Abl in Robo-Slit signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
Signaling by Robo receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
T Cell Receptor Signaling Pathway, organism-specific biosystem
T Cell Receptor Signaling Pathway
Viral myocarditis, organism-specific biosystem (from KEGG)
Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.
miRNA regulation of DNA Damage Response, organism-specific biosystem (from WikiPathways)
miRNA regulation of DNA Damage Response, organism-specific biosystemThis is the first out of two pathways which deals with the DNA damage response. It is comprised of two central gene products (ATM and ATR) influenced by different sources of DNA damage (in blue). The...

General gene information

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Markers

Abl1 (e-PCR), detects polymorphism
- UniSTS:527228

AI325092 (e-PCR)
- UniSTS:178600

Homology

Homologs of the Abl1 gene: The Abl1 gene is conserved in human, chimpanzee, dog, cow, rat, chicken, and zebrafish.
Map Viewer (Human, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
ATP binding	ISO Inferred from Sequence Orthology more info
DNA binding	IEA Inferred from Electronic Annotation more info
SH3 domain binding	ISO Inferred from Sequence Orthology more info
kinase activity	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	ISO Inferred from Sequence Orthology more info
manganese ion binding	IDA Inferred from Direct Assay more info	PubMed
manganese ion binding	ISO Inferred from Sequence Orthology more info
metal ion binding	IEA Inferred from Electronic Annotation more info
mitogen-activated protein kinase binding	ISO Inferred from Sequence Orthology more info
non-membrane spanning protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
proline-rich region binding	ISO Inferred from Sequence Orthology more info
protein C-terminus binding	ISO Inferred from Sequence Orthology more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
transferase activity	IEA Inferred from Electronic Annotation more info
transferase activity, transferring phosphorus-containing groups	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
DNA damage induced protein phosphorylation	ISO Inferred from Sequence Orthology more info
DNA repair	IEA Inferred from Electronic Annotation more info
actin cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
apoptotic process	IEA Inferred from Electronic Annotation more info
autophagy	IEA Inferred from Electronic Annotation more info
cell adhesion	IEA Inferred from Electronic Annotation more info
endocytosis	IEA Inferred from Electronic Annotation more info
negative regulation of protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
peptidyl-tyrosine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
phosphorylation	IEA Inferred from Electronic Annotation more info
platelet-derived growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info
positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
positive regulation of oxidoreductase activity	ISO Inferred from Sequence Orthology more info
positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
protein phosphorylation	IEA Inferred from Electronic Annotation more info
regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
regulation of response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
response to DNA damage stimulus	ISO Inferred from Sequence Orthology more info
signal transduction in response to DNA damage	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
cell leading edge	IDA Inferred from Direct Assay more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton	IEA Inferred from Electronic Annotation more info
cytosol	ISA Inferred from Sequence Alignment more info	PubMed
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleolus	ISO Inferred from Sequence Orthology more info
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	ISO Inferred from Sequence Orthology more info
perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
ruffle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase ABL1

Names: tyrosine-protein kinase ABL1; p150; proto-oncogene c-Abl; Abelson murine leukemia oncogene; Abelson tyrosine-protein kinase 1; v-abl Abelson murine leukemia oncogene 1; c-abl oncogene 1, receptor tyrosine kinase; proto-oncogene tyrosine-protein kinase ABL1; abelson murine leukemia viral oncogene homolog 1

NP_001106174.1

EC 2.7.10.2

NP_033724.2

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001112703.1 → NP_001106174.1 tyrosine-protein kinase ABL1 isoform a

Status: VALIDATED

Source sequence(s)

AK090095, AK166028, BC103770

Consensus CDS

CCDS50563.1

UniProtKB/Swiss-Prot

P00520

UniProtKB/TrEMBL

Q3SYK5

Conserved Domains (5) summary

pfam08919
Location:1003 – 1142
Blast Score: 621

F_actin_bind; F-actin binding

cd05052
Location:254 – 516
Blast Score: 1431

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

cd09935
Location:142 – 235
Blast Score: 499

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

pfam07714
Location:261 – 512
Blast Score: 1036

Pkinase_Tyr; Protein tyrosine kinase

cd11850
Location:84 – 137
Blast Score: 266

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
NM_009594.3 → NP_033724.2 tyrosine-protein kinase ABL1 isoform b

Status: VALIDATED

Source sequence(s)

AK090095, BC103770, BY152805, J02995

Consensus CDS

CCDS15901.1

UniProtKB/Swiss-Prot

P00520

UniProtKB/TrEMBL

Q3SYK5

Related

ENSMUSP00000028190, OTTMUSP00000013005, ENSMUST00000028190, OTTMUST00000028747

Conserved Domains (5) summary

pfam08919
Location:984 – 1123
Blast Score: 620

F_actin_bind; F-actin binding

cd05052
Location:235 – 497
Blast Score: 1428

PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

cd09935
Location:123 – 216
Blast Score: 501

SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins

pfam07714
Location:242 – 493
Blast Score: 1035

Pkinase_Tyr; Protein tyrosine kinase

cd11850
Location:65 – 118
Blast Score: 265

SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 103

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p1 C57BL/6J

Genomic

NC_000068.7 Reference GRCm38.p1 C57BL/6J

Range

31688556..31804227

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

AC_000024.1 Alternate Mm_Celera

Range

31389208..31506940

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein	Strain
Heading	Accession and Version	Protein	Strain
genomic	AAHY01015079.1 (16954..34940)	None
genomic	AAHY01015080.1	None
genomic	AAHY01015081.1	None
genomic	AAHY01015082.1	None
genomic	AAHY01015083.1	None
genomic	AAHY01015084.1 (17788..59775)	None
genomic	AL929275.8 (27482..143153)	None
genomic	CH466542.1	EDL08514.1	mixed
genomic	K02290.1	None
genomic	K02291.1	None
genomic	M12266.1	AAA37134.1	BALB/c
genomic	U13835.1	AAB60449.1
genomic	U14720.1	AAB60451.1
genomic	U14721.1	AAB60449.1
genomic	X07539.1	None	BALB/c
genomic	X07540.1	CAA30413.1	BALB/c
genomic	X07541.1	CAA30414.1	BALB/c
mRNA	AK037887.1	BAC29889.1	C57BL/6J
mRNA	AK083248.1	None	C57BL/6J
mRNA	AK088252.1	BAE43394.1	NOD
mRNA	AK090095.1	BAC41088.1
mRNA	AK090247.1	None	C57BL/6J
mRNA	AK166028.1	None
mRNA	AK166210.1	BAE38629.1
mRNA	AK190971.1	None
mRNA	AK194745.1	None
mRNA	AK203480.1	None
mRNA	AK207370.1	None
mRNA	AK213853.1	None
mRNA	AK213943.1	None
mRNA	AK214020.1	None
mRNA	AK215671.1	None
mRNA	AK218428.1	None
mRNA	AK218533.1	None
mRNA	AK219435.1	None
mRNA	BC013801.1	None	FVB/N
mRNA	BC035521.1	None	CZECHII
mRNA	BC059260.1	AAH59260.1	C57BL/6
mRNA	BC103770.1	AAI03771.1
mRNA	BY152805.1	None	C57BL/6J
mRNA	J02995.1	AAA88241.1
		AAA88242.1
mRNA	K03228.1	AAA37135.1	BALB/c
mRNA	L10656.1	None
mRNA	M12263.1	AAA37136.1	BALB/c
mRNA	M12264.1	AAA37137.1	BALB/c
mRNA	M12265.1	AAA37138.1	BALB/c