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Abl1 c-abl oncogene 1, non-receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 11350, updated on 15-May-2016
Official Symbol
Abl1provided by MGI
Official Full Name
c-abl oncogene 1, non-receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:87859
See related
Ensembl:ENSMUSG00000026842 Vega:OTTMUSG00000012077
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abl; c-Abl; AI325092; E430008G22Rik
Orthologs
Location:
2 21.86 cM; 2 B
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 2 NC_000068.7 (31688252..31807093)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (31544076..31659747)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 12 Neighboring gene exosome component 2 Neighboring gene fibrinogen C domain containing 1 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene laminin gamma 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117749

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
DNA binding IEA
Inferred from Electronic Annotation
more info
 
SH3 domain binding ISO
Inferred from Sequence Orthology
more info
 
actin filament binding IDA
Inferred from Direct Assay
more info
PubMed 
delta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
manganese ion binding IDA
Inferred from Direct Assay
more info
PubMed 
manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
non-membrane spanning protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
proline-rich region binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
protein tyrosine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
syntaxin binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell proliferation involved in immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
B cell proliferation involved in immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
B-1 B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
DNA damage induced protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
DNA repair IEA
Inferred from Electronic Annotation
more info
 
actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
actin filament branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
alpha-beta T cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebellum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
collateral sprouting IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of protein localization ISO
Inferred from Sequence Orthology
more info
 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
microspike assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-cell adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of endothelial cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
peptidyl-tyrosine autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
platelet-derived growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
platelet-derived growth factor receptor-beta signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of I-kappaB kinase/NF-kappaB signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of actin filament binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of interferon-gamma secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of interleukin-2 secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of microtubule binding ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of oxidoreductase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
PubMed 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
regulation of cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cellular senescence IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of extracellular matrix organization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
regulation of response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
signal transduction in response to DNA damage IBA
Inferred from Biological aspect of Ancestor
more info
 
signal transduction in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
spleen development IMP
Inferred from Mutant Phenotype
more info
PubMed 
substrate adhesion-dependent cell spreading IDA
Inferred from Direct Assay
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transitional one stage B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISA
Inferred from Sequence Alignment
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleolus ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
ruffle ISO
Inferred from Sequence Orthology
more info
 
synapse ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
tyrosine-protein kinase ABL1
Names
Abelson murine leukemia oncogene
Abelson tyrosine-protein kinase 1
abelson murine leukemia viral oncogene homolog 1
c-abl oncogene 1, receptor tyrosine kinase
c-abl protein, type I
c-abl protein, type II
c-abl protein, type III
p150
proto-oncogene c-Abl
proto-oncogene tyrosine-protein kinase ABL1
v-abl Abelson murine leukemia oncogene 1
NP_001106174.1
NP_001269974.1
NP_001269975.1
NP_001269976.1
NP_033724.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001112703.2NP_001106174.1  tyrosine-protein kinase ABL1 isoform a

    See identical proteins and their annotated locations for NP_001106174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest protein (isoform a).
    Source sequence(s)
    AK166028, AL929275, BC103770
    Consensus CDS
    CCDS50563.1
    UniProtKB/Swiss-Prot
    P00520
    UniProtKB/TrEMBL
    Q3SYK5
    Related
    ENSMUSP00000075167, OTTMUSP00000013004, ENSMUST00000075759, OTTMUST00000028740
    Conserved Domains (5) summary
    smart00808
    Location:10181142
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:142235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:261512
    Pkinase_Tyr; Protein tyrosine kinase
    cd05052
    Location:254516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  2. NM_001283045.1NP_001269974.1  tyrosine-protein kinase ABL1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform c) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL929275, BQ769074, CF536749, CF726668, CF727094
    UniProtKB/Swiss-Prot
    P00520
    Conserved Domains (5) summary
    smart00808
    Location:9941118
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:118211
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:60113
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:237488
    Pkinase_Tyr; Protein tyrosine kinase
    cd05052
    Location:230492
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  3. NM_001283046.1NP_001269975.1  tyrosine-protein kinase ABL1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate 5' exon compared to variant 1, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform d) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL929275
    UniProtKB/Swiss-Prot
    P00520
    Conserved Domains (5) summary
    smart00808
    Location:9931117
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:117210
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:59112
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:236487
    Pkinase_Tyr; Protein tyrosine kinase
    cd05052
    Location:229491
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  4. NM_001283047.1NP_001269976.1  tyrosine-protein kinase ABL1 isoform e

    See identical proteins and their annotated locations for NP_001269976.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' exon and uses a downstream start codon compared to variant 1. The resulting protein (isoform e) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL929275
    Conserved Domains (3) summary
    smart00808
    Location:763887
    FABD; F-actin binding domain (FABD)
    pfam07714
    Location:6257
    Pkinase_Tyr; Protein tyrosine kinase
    cd05052
    Location:1261
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  5. NM_009594.4NP_033724.2  tyrosine-protein kinase ABL1 isoform b

    See identical proteins and their annotated locations for NP_033724.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding region, and uses an alternate downstream start codon compared to variant 1. The resulting protein (isoform b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AL929275, BM949741, BU053120, CA752052, CF726668, CF727248, CJ099623, CJ101520, CJ128107, CK626997, CN663033
    Consensus CDS
    CCDS15901.1
    UniProtKB/Swiss-Prot
    P00520
    Related
    ENSMUSP00000028190, OTTMUSP00000013005, ENSMUST00000028190, OTTMUST00000028747
    Conserved Domains (5) summary
    smart00808
    Location:9991123
    FABD; F-actin binding domain (FABD)
    cd09935
    Location:123216
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:65118
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:242493
    Pkinase_Tyr; Protein tyrosine kinase
    cd05052
    Location:235497
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p3 C57BL/6J

    Range
    31688252..31807093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497621.2XP_006497684.1  

    Conserved Domains (4) summary
    cd09935
    Location:142235
    SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
    cd11850
    Location:84137
    SH3_Abl; Src homology 3 domain of the Protein Tyrosine Kinase, Abelson kinase
    pfam07714
    Location:261512
    Pkinase_Tyr; Protein tyrosine kinase
    cd05052
    Location:254516
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
  2. XM_011239012.1XP_011237314.1  

    See identical proteins and their annotated locations for XP_011237314.1

    Conserved Domains (3) summary
    smart00808
    Location:763887
    FABD; F-actin binding domain (FABD)
    pfam07714
    Location:6257
    Pkinase_Tyr; Protein tyrosine kinase
    cd05052
    Location:1261
    PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase

Alternate Mm_Celera

Genomic

  1. AC_000024.1 Alternate Mm_Celera

    Range
    31389189..31507075
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)