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    Abl1 c-abl oncogene 1, non-receptor tyrosine kinase [ Mus musculus ]

    Gene ID: 11350, updated on 20-May-2012
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    Summary

    Official Symbol
    Abl1provided by MGI
    Official Full Name
    c-abl oncogene 1, non-receptor tyrosine kinaseprovided by MGI
    Primary source
    MGI:87859
    Locus tag
    RP23-65P13.3
    See related
    Ensembl:ENSMUSG00000026842; Vega:OTTMUSG00000012077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abl; c-Abl; AI325092; E430008G22Rik; MGC117749
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    Genomic context

    Location :
    2 B; 2 21.0 cM
    Sequence :
    Chromosome: 2; NC_000068.7 (31688556..31804227)
    See Abl1 in Epigenomics, MapViewer

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene 13425 Neighboring gene PR domain containing 12 Neighboring gene exosome component 2 Neighboring gene pyroglutamylated RFamide peptide Neighboring gene fibrinogen C domain containing 1

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity. Gourley SL, et al. J Neurosci, 2012 Feb 15. PMID 22396406.
    2. c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr-218. Matsubara T, et al. J Biol Chem, 2012 Feb 17. PMID 22199356.
    3. The c-Abl expression in uterine epithelium during the mouse estrus cycle. Ucar AY, et al. J Mol Histol, 2012 Feb. PMID 22143492.
    4. Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis. Grebien F, et al. Cell, 2011 Oct 14. PMID 22000011.
    5. CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis. Zhuang C, et al. J Biol Chem, 2011 Nov 4. PMID 21900237.

    See all (244) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. the stage-specific protein pattern of the mammalian c-Abl tyrosine kinase presented a good correlation with the mouse estrus cycle and may have a regulative function during the uterine remodeling.
      Title: The c-Abl expression in uterine epithelium during the mouse estrus cycle.
    2. the nucleo-cytoplasmic shuttling of DGKalpha is orchestrated by tyrosine phosphorylation by the Src-activated tyrosine kinase c-Abl
      Title: c-Abl tyrosine kinase regulates serum-induced nuclear export of diacylglycerol kinase α by phosphorylation at Tyr-218.
    3. ZnMt3 in cultured astrocytes may be a normal component of c-Abl activation in EGF receptor signaling
      Title: Role of zinc metallothionein-3 (ZnMt3) in epidermal growth factor (EGF)-induced c-Abl protein activation and actin polymerization in cultured astrocytes.
    4. CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis
      Title: CDK1-mediated phosphorylation of Abi1 attenuates Bcr-Abl-induced F-actin assembly and tyrosine phosphorylation of WAVE complex during mitosis.
    5. The data confirm that BCR-ABL promotes ROS and demonstrate that NF-kappaB prevents excessive levels.
      Title: NF-κB suppresses ROS levels in BCR-ABL(+) cells to prevent activation of JNK and cell death.
    6. Study shows that an intramolecular interaction between the SH2 and kinase domains in Bcr-Abl is both necessary and sufficient for high catalytic activity of the enzyme.
      Title: Targeting the SH2-kinase interface in Bcr-Abl inhibits leukemogenesis.
    7. c-Abl regulates Th cell differentiation in a T-bet-dependent manner
      Title: c-Abl-mediated tyrosine phosphorylation of the T-bet DNA-binding domain regulates CD4+ T-cell differentiation and allergic lung inflammation.
    8. these results demonstrate a role for c-Abl in uterine remodeling during decidualization, implantation, and placentation throughout gestation
      Title: The abelson tyrosine kinase (c-Abl) expression on the mouse uterus and placenta during gestational period.
    9. (18)F-SKI696 is taken up in vivo by tumors that overexpress Bcr-Abl
      Title: In vivo imaging of Bcr-Abl overexpressing tumors with a radiolabeled imatinib analog as an imaging surrogate for imatinib.
    10. p90RSK2 is dispensable for BCR-Abl-induced myeloid leukemia, but may be required for pathogenesis and lineage determination in Flt3-internal tandem duplication-induced hematopoietic transformation.
      Title: p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.
    Submit: New GeneRIF Correction See all (78)
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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_033724.1 NP_033724.1 Abl1    BIND  PubMed c-Abl undergoes autophosphorylation. 
    NP_033724.1 NP_071304.1 Cables1    BIND  PubMed Cables interacts with the SH3 domain of c-Abl. 
    NP_033724.1 NP_665850.1 Cables2    BIND  PubMed Ik3-2 interacts with c-Abl. 
    NP_033724.1 NP_034200.3 Dok1    BIND  PubMed c-Abl interacts with Dok1. 
    NP_033724.1 AAC52863.1 Enah    BIND  PubMed Mena interacts with Abl. This interaction was modelled on a demonstrated interaction between mouse Mena and Abl from an unspecified species. 
    NP_033724.1 NP_031991.2 Evl    BIND  PubMed EVL interacts with Abl SH3 domain. This interaction was modeled on a demonstrated interaction between mouse EVL and Abl from an unspecified species. 
    NP_033724.1 NP_954711.1 Sema6d    BIND  PubMed Sema6D interacts with Abl kinase. 
    BioGRID:197906 BioGRID:201466 Grap2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:197906 BioGRID:206136 Park2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:197906 BioGRID:202525 Pxn    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:197906 BioGRID:230435 Rin1    BioGRID  PubMed Biochemical Activity; Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Alpha6-Beta4 Integrin Signaling Pathway, organism-specific biosystemIntegrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands...
    • Axon guidance, organism-specific biosystem (from KEGG)
      Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, conserved biosystem (from KEGG)
      Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle signaling pathway, organism-specific biosystem (from LIPID MAPS)
      Cell cycle signaling pathway, organism-specific biosystem
      Cell cycle signaling pathway
    • Chronic myeloid leukemia, organism-specific biosystem (from KEGG)
      Chronic myeloid leukemia, organism-specific biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Chronic myeloid leukemia, conserved biosystem (from KEGG)
      Chronic myeloid leukemia, conserved biosystemChronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and ot...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • ErbB signaling pathway, organism-specific biosystem (from KEGG)
      ErbB signaling pathway, organism-specific biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • ErbB signaling pathway, organism-specific biosystem (from WikiPathways)
      ErbB signaling pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
    • ErbB signaling pathway, conserved biosystem (from KEGG)
      ErbB signaling pathway, conserved biosystemThe ErbB family of receptor tyrosine kinases (RTKs) couples binding of extracellular growth factor ligands to intracellular signaling pathways regulating diverse biologic responses, including prolife...
    • Kit Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      Kit Receptor Signaling Pathway, organism-specific biosystemKit is a receptor protein tyrosine kinase, which is a receptor for stem cell factor or kit ligand. Signaling through Kit is important for formation of red cells, lymphocytes, mast cells and platelets...
    • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
      Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
      Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Role of Abl in Robo-Slit signaling, organism-specific biosystem (from REACTOME)
      Role of Abl in Robo-Slit signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Signaling by Robo receptor, organism-specific biosystem (from REACTOME)
      Signaling by Robo receptor, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • T Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
      T Cell Receptor Signaling Pathway, organism-specific biosystem
      T Cell Receptor Signaling Pathway
    • Viral myocarditis, organism-specific biosystem (from KEGG)
      Viral myocarditis, organism-specific biosystemMyocarditis is a cardiac disease associated with inflammation and injury of the myocardium. It results from various etiologies, both noninfectious and infectious, but coxsackievirus B3 (CVB3) is stil...

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitogen-activated protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    non-membrane spanning protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    proline-rich region binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    transferase activity, transferring phosphorus-containing groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    DNA damage induced protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    negative regulation of protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    positive regulation of oxidoreductase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    response to DNA damage stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytosol ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
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    General protein information

    Preferred Names
    tyrosine-protein kinase ABL1
    Names
    tyrosine-protein kinase ABL1
    p150
    proto-oncogene c-Abl
    Abelson murine leukemia oncogene
    Abelson tyrosine-protein kinase 1
    v-abl Abelson murine leukemia oncogene 1
    c-abl oncogene 1, receptor tyrosine kinase
    proto-oncogene tyrosine-protein kinase ABL1
    abelson murine leukemia viral oncogene homolog 1
    NP_001106174.1
    NP_033724.2
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001112703.1 → NP_001106174.1  tyrosine-protein kinase ABL1 isoform a

      Status: VALIDATED

      Source sequence(s)
      AK090095, AK166028, BC103770
      Consensus CDS
      CCDS50563.1
      UniProtKB/Swiss-Prot
      P00520
      UniProtKB/TrEMBL
      Q3SYK5
      Related
      ENSMUSP00000075167, OTTMUSP00000013004, ENSMUST00000075759, OTTMUST00000028740
      Conserved Domains (5) summary
      cd00174
      Location:85 – 137
      Blast Score: 150
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05052
      Location:254 – 516
      Blast Score: 1431
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:142 – 235
      Blast Score: 499
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cl07494
      Location:1003 – 1142
      Blast Score: 621
      F_actin_bind; F-actin binding
      pfam07714
      Location:261 – 512
      Blast Score: 1036
      Pkinase_Tyr; Protein tyrosine kinase

    2. NM_009594.3 → NP_033724.2  tyrosine-protein kinase ABL1 isoform b

      Status: VALIDATED

      Source sequence(s)
      AK090095, BC103770, BY152805, J02995
      Consensus CDS
      CCDS15901.1
      UniProtKB/TrEMBL
      A2AV22
      UniProtKB/Swiss-Prot
      P00520
      UniProtKB/TrEMBL
      Q3SYK5
      Related
      ENSMUSP00000028190, OTTMUSP00000013005, ENSMUST00000028190, OTTMUST00000028747
      Conserved Domains (5) summary
      cd00174
      Location:66 – 118
      Blast Score: 150
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05052
      Location:235 – 497
      Blast Score: 1428
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      cd09935
      Location:123 – 216
      Blast Score: 501
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cl07494
      Location:984 – 1123
      Blast Score: 620
      F_actin_bind; F-actin binding
      pfam07714
      Location:242 – 493
      Blast Score: 1035
      Pkinase_Tyr; Protein tyrosine kinase

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38 C57BL/6J

      Range
      31688556..31804227
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000024.1 Alternate Mm_Celera

      Range
      31389208..31506940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AL929275.8 CAM26563.1
      CAM26564.1
      CAM26565.1
    genomic CH466542.1 EDL08514.1 mixed
    genomic K02290.1 None
    genomic K02291.1 None
    genomic M12266.1 AAA37134.1 BALB/c
    genomic U13835.1 AAB60449.1
    genomic U14720.1 AAB60451.1
    genomic U14721.1 AAB60449.1
    genomic X07539.1 None BALB/c
    genomic X07540.1 CAA30413.1 BALB/c
    genomic X07541.1 CAA30414.1 BALB/c
    mRNA AK037887.1 BAC29889.1 C57BL/6J
    mRNA AK083248.1 None C57BL/6J
    mRNA AK088252.1 BAE43394.1 NOD
    mRNA AK090095.1 BAC41088.1
    mRNA AK090247.1 None C57BL/6J
    mRNA AK166028.1 None
    mRNA AK166210.1 BAE38629.1
    mRNA AK190971.1 None
    mRNA AK194745.1 None
    mRNA AK203480.1 None
    mRNA AK207370.1 None
    mRNA AK213853.1 None
    mRNA AK213943.1 None
    mRNA AK214020.1 None
    mRNA AK215671.1 None
    mRNA AK218428.1 None
    mRNA AK218533.1 None
    mRNA AK219435.1 None
    mRNA BC013801.1 None FVB/N
    mRNA BC035521.1 None CZECHII
    mRNA BC059260.1 AAH59260.1 C57BL/6
    mRNA BC103770.1 AAI03771.1
    mRNA BY152805.1 None C57BL/6J
    mRNA J02995.1 AAA88241.1
      AAA88242.1
    mRNA K03228.1 AAA37135.1 BALB/c
    mRNA L10656.1 None
    mRNA M12263.1 AAA37136.1 BALB/c
    mRNA M12264.1 AAA37137.1 BALB/c
    mRNA M12265.1 AAA37138.1 BALB/c
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00520.3 GenPept UniProtKB/Swiss-Prot:P00520
    Q3SYK5 GenPept UniProtKB/TrEMBL:Q3SYK5
    Q3TM13 GenPept UniProtKB/TrEMBL:Q3TM13
    Q3V2W1 GenPept UniProtKB/TrEMBL:Q3V2W1
    Q61262 GenPept UniProtKB/TrEMBL:Q61262
    Q8CAT4 GenPept UniProtKB/TrEMBL:Q8CAT4
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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