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RNF13 ring finger protein 13 [ Homo sapiens (human) ]

Gene ID: 11342, updated on 8-May-2016
Official Symbol
RNF13provided by HGNC
Official Full Name
ring finger protein 13provided by HGNC
Primary source
HGNC:HGNC:10057
See related
Ensembl:ENSG00000082996 HPRD:11503; MIM:609247; Vega:OTTHUMG00000150338
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RZF
Summary
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
3q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (149812484..149962139)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149530475..149679926)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene COMM domain containing 2 Neighboring gene ankyrin repeat and ubiquitin domain containing 1 Neighboring gene uncharacterized LOC105374152 Neighboring gene nucleophosmin 1 (nucleolar phosphoprotein B23, numatrin) pseudogene 29 Neighboring gene uncharacterized LOC646903 Neighboring gene profilin 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ93817, MGC13689

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein autoubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
late endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
lysosomal membrane IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
E3 ubiquitin-protein ligase RNF13
Names
RING zinc finger protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007282.4NP_009213.1  E3 ubiquitin-protein ligase RNF13

    See identical proteins and their annotated locations for NP_009213.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC117395, BC009803, CB109037, DA031838
    Consensus CDS
    CCDS3146.1
    UniProtKB/Swiss-Prot
    O43567
    Related
    ENSP00000341361, OTTHUMP00000216206, ENST00000344229, OTTHUMT00000356876
    Conserved Domains (2) summary
    cd00162
    Location:240285
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd02123
    Location:23180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
  2. NM_183381.2NP_899237.1  E3 ubiquitin-protein ligase RNF13

    See identical proteins and their annotated locations for NP_899237.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC117395, AK090638, DA031838
    Consensus CDS
    CCDS3146.1
    UniProtKB/Swiss-Prot
    O43567
    Related
    ENSP00000376628, OTTHUMP00000197095, ENST00000392894, OTTHUMT00000317669
    Conserved Domains (2) summary
    cd00162
    Location:240285
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd02123
    Location:23180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

    Range
    149812484..149962139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512373.1XP_011510675.1  

    See identical proteins and their annotated locations for XP_011510675.1

    UniProtKB/Swiss-Prot
    O43567
    Conserved Domains (2) summary
    cd00162
    Location:240285
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd02123
    Location:23180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
  2. XM_011512374.1XP_011510676.1  

    See identical proteins and their annotated locations for XP_011510676.1

    UniProtKB/Swiss-Prot
    O43567
    Conserved Domains (2) summary
    cd00162
    Location:240285
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd02123
    Location:23180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
  3. XM_011512375.1XP_011510677.1  

    See identical proteins and their annotated locations for XP_011510677.1

    UniProtKB/Swiss-Prot
    O43567
    Conserved Domains (2) summary
    cd00162
    Location:240285
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd02123
    Location:23180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
  4. XM_005247092.2XP_005247149.1  

    See identical proteins and their annotated locations for XP_005247149.1

    UniProtKB/Swiss-Prot
    O43567
    Related
    ENSP00000420667, OTTHUMP00000216210, ENST00000491086, OTTHUMT00000356880
    Conserved Domains (2) summary
    cd00162
    Location:121166
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl10459
    Location:2161
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families
  5. XM_011512372.1XP_011510674.1  

    See identical proteins and their annotated locations for XP_011510674.1

    UniProtKB/Swiss-Prot
    O43567
    Conserved Domains (2) summary
    cd00162
    Location:240285
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd02123
    Location:23180
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
  6. XM_011512376.1XP_011510678.1  

    See identical proteins and their annotated locations for XP_011510678.1

    UniProtKB/Swiss-Prot
    O43567
    Related
    ENSP00000355268, OTTHUMP00000216205, ENST00000361785, OTTHUMT00000356875
    Conserved Domains (2) summary
    cd00162
    Location:121166
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl10459
    Location:2161
    Peptidases_S8_S53; Peptidase domain in the S8 and S53 families

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 Alternate CHM1_1.1

    Range
    149493567..149643086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_183382.1: Suppressed sequence

    Description
    NM_183382.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_183383.2: Suppressed sequence

    Description
    NM_183383.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  3. NM_183384.2: Suppressed sequence

    Description
    NM_183384.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.