PDAP1 PDGFA associated protein 1 [Homo sapiens] - Gene

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Summary

Official Symbol: PDAP1provided by HGNC
Official Full Name: PDGFA associated protein 1provided by HGNC
Primary source: HGNC:14634
See related: Ensembl:ENSG00000106244; HPRD:06149; MIM:607075; Vega:OTTHUMG00000154629
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PAP; PAP1; HASPP28
Summary: The protein encoded by this gene is a phosphoprotein that may upregulate the PDGFA-stimulated growth of fibroblasts and also downregulate the mitogenicity of PDGFB. The encoded protein in rodents has been shown to bind PDGFA with a low affinity. [provided by RefSeq, Dec 2010]

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Genomic context

Location :: 7q22.1

Sequence :: Chromosome: 7; NC_000007.13 (98992296..99006305, complement)

See PDAP1 in Epigenomics, MapViewer

Chromosome 7 - NC_000007.13 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q13442	P04085	PDGFA	HPRD	PubMed
Q13442	P01127	PDGFB	HPRD	PubMed
Q13442	P09619	PDGFRB	HPRD	PubMed
BioGRID:116461	BioGRID:111180	PDGFA	BioGRID	PubMed	Co-purification
BioGRID:116461	BioGRID:111181	PDGFB	BioGRID	PubMed	Co-purification

Process	Evidence Code	Pubs
cell proliferation	TAS Traceable Author Statement more info	PubMed
signal transduction	TAS Traceable Author Statement more info	PubMed

General protein information

Preferred Names: 28 kDa heat- and acid-stable phosphoprotein

Names: 28 kDa heat- and acid-stable phosphoprotein; PDGF-associated protein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028040.1 RefSeqGene

Range

5001..19010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_014891.6 → NP_055706.1 28 kDa heat- and acid-stable phosphoprotein

Status: REVIEWED

Source sequence(s)

AC004922, BC000684, BC001578, BG281467, BI460344

Consensus CDS

CCDS5662.1

UniProtKB/Swiss-Prot

Q13442

Related

ENSP00000222968, OTTHUMP00000206311, ENST00000350498, OTTHUMT00000336388

Conserved Domains (1) summary

pfam10252
Location:84 – 146
Blast Score: 200

PP28; Casein kinase substrate phosphoprotein PP28

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000007.13 Reference GRCh37.p5 Primary Assembly

Range

98992296..99006305, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000139.1 Alternate HuRef

Range

93628007..93642048, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CRA_TCAGchr7v2

Genomic

AC_000068.1 Alternate CRA_TCAGchr7v2

Range

98352069..98366079, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC004922.2	AAF03506.1
genomic	CH236956.1 (1545028..1558732)	None
genomic	CH471091.2	EAW76674.1
		EAW76675.1
		EAW76676.1
genomic	U65960.1	AAB07135.1
mRNA	AA464753.1	None
mRNA	BC000684.2	AAH00684.1
mRNA	BC001578.1	None
mRNA	BC007873.2	AAH07873.1
mRNA	BC039130.1	None
mRNA	BC071993.1	None
mRNA	BE543808.1	None
mRNA	BF037671.1	None
mRNA	BG281467.1	None
mRNA	BI460344.1	None
mRNA	BQ215882.1	None
mRNA	CB852527.1	None
mRNA	U41745.1	AAC50462.1