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CTRC chymotrypsin C [ Homo sapiens (human) ]

Gene ID: 11330, updated on 26-May-2016
Official Symbol
CTRCprovided by HGNC
Official Full Name
chymotrypsin Cprovided by HGNC
Primary source
HGNC:HGNC:2523
See related
Ensembl:ENSG00000162438 HPRD:03242; MIM:601405; Vega:OTTHUMG00000002255
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLCR; ELA4
Summary
This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
Orthologs
Location:
1p36.21
Exon count:
8
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (15438442..15449247)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (15764938..15773153)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene forkhead-associated (FHA) phosphopeptide binding domain 1 Neighboring gene uncharacterized LOC101927417 Neighboring gene uncharacterized LOC101927441 Neighboring gene EF-hand domain family member D2 Neighboring gene uncharacterized LOC105376767 Neighboring gene chymotrypsin like elastase family member 2A Neighboring gene chymotrypsin like elastase family member 2B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystem (from REACTOME)
    Cobalamin (Cbl, vitamin B12) transport and metabolism, organism-specific biosystemVitamin B12 (cobalamin, Cbl) is a water-soluble vitamin with a key role in blood formation and normal functioning of the brain and nervous system. Cbl consists of a planar corrin ring coordinating wi...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
peptidase activity TAS
Traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cobalamin metabolic process TAS
Traceable Author Statement
more info
 
proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
Preferred Names
chymotrypsin-C
Names
caldecrin
chymotrypsin C (caldecrin)
elastase 4
elastase IV
serum calcium decreasing factor
NP_009203.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009253.1 RefSeqGene

    Range
    5001..13216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007272.2NP_009203.2  chymotrypsin-C preproprotein

    See identical proteins and their annotated locations for NP_009203.2

    Status: REVIEWED

    Source sequence(s)
    BC015118, S82198
    Consensus CDS
    CCDS156.1
    UniProtKB/Swiss-Prot
    Q99895
    Related
    ENSP00000365116, OTTHUMP00000002321, ENST00000375949, OTTHUMT00000006435
    Conserved Domains (2) summary
    smart00020
    Location:29262
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:30265
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    15438442..15449247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540550.1XP_011538852.1  

    Conserved Domains (2) summary
    smart00020
    Location:29163
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:30173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    15563607..15571831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)