STK38 serine/threonine kinase 38 [Homo sapiens] - Gene

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Summary

Official Symbol: STK38provided by HGNC
Official Full Name: serine/threonine kinase 38provided by HGNC
Primary source: HGNC:17847
See related: Ensembl:ENSG00000112079; HPRD:09511; MIM:606964; Vega:OTTHUMG00000014598
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NDR; NDR1

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Genomic context

Location :: 6p21

Sequence :: Chromosome: 6; NC_000006.11 (36461669..36515247, complement)

See STK38 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GSK-3beta inhibits full activation of STK38, and STK38 activation is required to prevent cell death in response to oxidative stress
Title: Serine-threonine kinase 38 is regulated by glycogen synthase kinase-3 and modulates oxidative stress-induced cell death.
Findings show a biological role for MICAL-1 in apoptosis and define a novel negative regulatory mechanism of MST-NDR signaling.
Title: MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis.
These findings establish a novel MST3-NDR-p21 axis as an important regulator of G(1)/S progression of mammalian cells.
Title: Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.
Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings.
Title: Differential NDR/LATS interactions with the human MOB family reveal a negative role for human MOB2 in the regulation of human NDR kinases.
Results suggest that MST2-, Fry-, and MOB2-mediated activation of NDR1 is crucial for the fidelity of mitotic chromosome alignment in mammalian cells.
Title: MST2- and Furry-mediated activation of NDR1 kinase is critical for precise alignment of mitotic chromosomes.
findings identify NDR1/2 as novel proapoptotic kinases and key members of the RASSF1A/MST1 signaling cascade
Title: NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.
Observational study of gene-disease association. (HuGE Navigator)
Title: A common variant in DRD3 receptor is associated with autism spectrum disorder.
phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1
Title: Threonine 74 of MOB1 is a putative key phosphorylation site by MST2 to form the scaffold to activate nuclear Dbf2-related kinase 1.
The NDR1 and NDR2 kinases were incorporated into HIV-1 particles and were cleaved by the HIV-1 protease.
Title: HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.
In vivo activation of human NDR by membrane-bound hMOBs is dependent on their interaction and occurs solely at the membrane.
Title: Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_009202.1	NP_004706.2	CTDP1	BIND	PubMed	FCP1 interacts with NDR1.
Q15208	Q9Y5B0	CTDP1	HPRD	PubMed
Q15208	HCCA2 protein	MOB2	HPRD	PubMed
Q15208	P04271	S100B	HPRD	PubMed
Q15208	Q15208	STK38	HPRD	PubMed
Q15208	P31946	YWHAB	HPRD	PubMed
Q15208	P63104	YWHAZ	HPRD	PubMed
BioGRID:116457	BioGRID:114597	CTDP1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:116457	BioGRID:206143	Chek2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116457	BioGRID:128177	EIF2C3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116457	BioGRID:119365	HERC5	BioGRID	PubMed	Reconstituted Complex
BioGRID:116457	BioGRID:114995	ISG15	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116457	BioGRID:125363	MYSM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116457	BioGRID:223068	Stk38	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116457	BioGRID:113500	TRIM25	BioGRID	PubMed	Reconstituted Complex
BioGRID:116457	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116457	BioGRID:113269	VHL	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116457	BioGRID:113361	YWHAB	BioGRID	PubMed	Affinity Capture-MS
BioGRID:116457	BioGRID:113366	YWHAZ	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
mitogen-activated protein kinase kinase kinase binding	IPI Inferred from Physical Interaction more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
intracellular protein kinase cascade	IDA Inferred from Direct Assay more info	PubMed
negative regulation of MAP kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein modification process	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
MLL5-L complex	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: serine/threonine-protein kinase 38

Names: serine/threonine-protein kinase 38; NDR1 protein kinase; nuclear Dbf2-related 1; nuclear Dbf2-related kinase 1; Ndr Ser/Thr kinase-like protein; serine threonine protein kinase

NP_009202.1

EC 2.7.11.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007271.2 → NP_009202.1 serine/threonine-protein kinase 38

Status: PROVISIONAL

Source sequence(s)

BC012085

Consensus CDS

CCDS4822.1

UniProtKB/Swiss-Prot

Q15208

Related

ENSP00000229812, OTTHUMP00000016293, ENST00000229812, OTTHUMT00000040346

Conserved Domains (2) summary

cd05628
Location:87 – 449
Blast Score: 1950

STKc_NDR1; Catalytic domain of the Protein Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1

smart00220
Location:89 – 382
Blast Score: 727

S_TKc; Serine/Threonine protein kinases, catalytic domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p5 Primary Assembly

Range

36461669..36515247, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

36180534..36234118, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	CH471081.1	EAX03894.1
		EAX03895.1
		EAX03896.1
genomic	CQ826789.1	CAG44584.1
genomic	Z85986.1	CAB39180.1
mRNA	AF034188.1	AAD50530.1
mRNA	AK312559.1	BAG35456.1
mRNA	BC012085.1	AAH12085.1
mRNA	BC095413.1	AAH95413.1
mRNA	Z35102.1	CAA84485.1
other-genetic	EU832099.1	ACE87449.1
other-genetic	EU832192.1	ACE86762.1