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KIF12 kinesin family member 12 [ Homo sapiens (human) ]

Gene ID: 113220, updated on 26-May-2016
Official Symbol
KIF12provided by HGNC
Official Full Name
kinesin family member 12provided by HGNC
Primary source
HGNC:HGNC:21495
See related
Ensembl:ENSG00000136883 HPRD:13914; MIM:611278; Vega:OTTHUMG00000020533
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
KIF12 is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008]
Orthologs
Location:
9q32
Exon count:
21
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (114091623..114100084, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (116853903..116861600, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger protein 618 Neighboring gene uncharacterized LOC105376226 Neighboring gene alpha-1-microglobulin/bikunin precursor Neighboring gene uncharacterized LOC105376225 Neighboring gene collagen type XXVII alpha 1 Neighboring gene microRNA 455

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study of Tourette's syndrome.
NHGRI GWA Catalog
  • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
    COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
  • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
    Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
  • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
    Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Kinesins, organism-specific biosystem (from REACTOME)
    Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ATPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138424.1NP_612433.1  kinesin-like protein KIF12

    See identical proteins and their annotated locations for NP_612433.1

    Status: PROVISIONAL

    Source sequence(s)
    BC010626
    Consensus CDS
    CCDS6801.1
    UniProtKB/Swiss-Prot
    Q96FN5
    UniProtKB/TrEMBL
    B1ALC3
    Related
    ENSP00000363232, OTTHUMP00000021965, ENST00000374118, OTTHUMT00000053751
    Conserved Domains (3) summary
    pfam12711
    Location:244331
    Kinesin-relat_1; Kinesin motor
    pfam00225
    Location:1227
    Kinesin; Kinesin motor domain
    cd00106
    Location:1225
    KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    114091623..114100084 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518190.1XP_011516492.1  

    Conserved Domains (3) summary
    pfam12711
    Location:440527
    Kinesin-relat_1; Kinesin motor
    pfam00225
    Location:110423
    Kinesin; Kinesin motor domain
    cd00106
    Location:123421
    KISc; Kinesin motor domain
  2. XM_011518191.1XP_011516493.1  

    Conserved Domains (3) summary
    pfam12711
    Location:440527
    Kinesin-relat_1; Kinesin motor
    pfam00225
    Location:110423
    Kinesin; Kinesin motor domain
    cd00106
    Location:123421
    KISc; Kinesin motor domain
  3. XM_005251683.3XP_005251740.1  

    Conserved Domains (3) summary
    pfam12711
    Location:382469
    Kinesin-relat_1; Kinesin motor
    pfam00225
    Location:31365
    Kinesin; Kinesin motor domain
    cd00106
    Location:25363
    KISc; Kinesin motor domain
  4. XM_006716947.1XP_006717010.1  

    Conserved Domains (3) summary
    pfam12711
    Location:348435
    Kinesin-relat_1; Kinesin motor
    pfam00225
    Location:1331
    Kinesin; Kinesin motor domain
    cd00106
    Location:8329
    KISc; Kinesin motor domain
  5. XM_011518192.1XP_011516494.1  

    Conserved Domains (3) summary
    pfam12711
    Location:440527
    Kinesin-relat_1; Kinesin motor
    pfam00225
    Location:110423
    Kinesin; Kinesin motor domain
    cd00106
    Location:123421
    KISc; Kinesin motor domain
  6. XM_011518193.1XP_011516495.1  

    Conserved Domains (1) summary
    cl22853
    Location:123315
    Motor_domain; Myosin and Kinesin motor domain.

RNA

  1. XR_929710.1 RNA Sequence

  2. XR_929708.1 RNA Sequence

  3. XR_929709.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    117000368..117007780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)