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CHST14 carbohydrate sulfotransferase 14 [ Homo sapiens (human) ]

Gene ID: 113189, updated on 10-May-2016
Official Symbol
CHST14provided by HGNC
Official Full Name
carbohydrate sulfotransferase 14provided by HGNC
Primary source
HGNC:HGNC:24464
See related
Ensembl:ENSG00000169105 HPRD:16780; MIM:608429
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATCS; D4ST1; EDSMC1; HNK1ST
Summary
This gene encodes a member of the HNK-1 family of sulfotransferases. The encoded protein transfers sulfate to the C-4 hydroxyl of N-acetylgalactosamine residues in dermatan sulfate. Mutations in this gene have been associated with adducted thumb-clubfoot syndrome.[provided by RefSeq, Mar 2010]
Orthologs
Location:
15q15.1
Exon count:
1
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (40470961..40473158)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40763160..40765357)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene isovaleryl-CoA dehydrogenase Neighboring gene bromo adjacent homology domain containing 1 Neighboring gene ribosomal protein L9 pseudogene 27 Neighboring gene chromosome 15 open reading frame 57 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 (CHST14) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
N-acetylgalactosamine 4-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
N-acetylgalactosamine 4-O-sulfotransferase activity TAS
Traceable Author Statement
more info
 
phosphate ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
carbohydrate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
dermatan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
dermatan sulfate proteoglycan metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
Preferred Names
carbohydrate sulfotransferase 14
Names
carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14
carbohydrate (dermatan 4) sulfotransferase 14
dermatan 4 sulfotransferase 1
NP_569735.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017074.1 RefSeqGene

    Range
    5001..7198
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_600

mRNA and Protein(s)

  1. NM_130468.3NP_569735.1  carbohydrate sulfotransferase 14

    See identical proteins and their annotated locations for NP_569735.1

    Status: REVIEWED

    Source sequence(s)
    AB066595, CR997569
    Consensus CDS
    CCDS10059.1
    UniProtKB/Swiss-Prot
    Q8NCH0
    Related
    ENSP00000307297, OTTHUMP00000160446, ENST00000306243, OTTHUMT00000252251
    Conserved Domains (1) summary
    pfam03567
    Location:144364
    Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    40470961..40473158
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    40883323..40885520
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)