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Tiam2 TIAM Rac1 associated GEF 2 [ Urocitellus parryii (Arctic ground squirrel) ]

Gene ID: 113186385, updated on 15-Mar-2024

Summary

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Gene symbol
Tiam2
Gene description
TIAM Rac1 associated GEF 2
See related
Ensembl:ENSUPAG00010016263
Gene type
protein coding
RefSeq status
MODEL
Organism
Urocitellus parryii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae; Xerinae; Marmotini; Urocitellus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
29
Annotation release Status Assembly Chr Location
100 current ASM342692v1 (GCF_003426925.1) Unplaced Scaffold NW_020540015.1 (849079..977474)

NW_020540015.1Genomic Context describing neighboring genes Neighboring gene actin, alpha skeletal muscle-like Neighboring gene SR-related CTD associated factor 8 Neighboring gene U6 spliceosomal RNA Neighboring gene transcription factor B1, mitochondrial Neighboring gene claudin 20 Neighboring gene NADPH oxidase 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020540015 Unplaced Scaffold Reference ASM342692v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
T-lymphoma invasion and metastasis-inducing protein 2
Names
T cell lymphoma invasion and metastasis 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Urocitellus parryii Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM342692v1

Genomic

  1. NW_020540015.1 Reference ASM342692v1

    Range
    849079..977474
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_026393814.1 → XP_026249599.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8D2KKY7
    Related
    ENSUPAP00010020714.1, ENSUPAT00010023568.1
    Conserved Domains (5) summary
    smart00325
    Location:1127 → 1316
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:912 → 997
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:505 → 631
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1318 → 1490
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    cl00155
    Location:835 → 910
    UBQ; Ubiquitin-like proteins

  2. XM_026393813.1 → XP_026249598.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8D2KKY7
    Related
    ENSUPAP00010020660.1, ENSUPAT00010023508.1
    Conserved Domains (5) summary
    smart00325
    Location:1127 → 1316
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd00992
    Location:912 → 997
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01230
    Location:505 → 631
    PH1_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, N-terminal domain
    cd01255
    Location:1318 → 1490
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
    cl00155
    Location:835 → 910
    UBQ; Ubiquitin-like proteins

  3. XM_026393815.1 → XP_026249600.1  T-lymphoma invasion and metastasis-inducing protein 2 isoform X2

    Conserved Domains (2) summary
    smart00325
    Location:1 → 153
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01255
    Location:155 → 327
    PH2_Tiam1_2; T-lymphoma invasion and metastasis 1 and 2 Pleckstrin Homology (PH) domain, C-terminal domain
Nucleotide Protein
Heading Accession and Version

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