Format

Send to:

Choose Destination

GPR182 G protein-coupled receptor 182 [ Homo sapiens (human) ]

Gene ID: 11318, updated on 12-May-2016
Official Symbol
GPR182provided by HGNC
Official Full Name
G protein-coupled receptor 182provided by HGNC
Primary source
HGNC:HGNC:13708
See related
Ensembl:ENSG00000166856 HPRD:05605; MIM:605307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMR; 7TMR; ADMR; AM-R; G10D; gamrh; hrhAMR
Summary
Adrenomedullin is a potent vasodilator peptide that exerts major effects on cardiovascular function. This gene encodes a seven-transmembrane protein that belongs to the family 1 of G-protein coupled receptors. Studies of the rat counterpart suggest that the encoded protein may function as a receptor for adrenomedullin. [provided by RefSeq, Jul 2008]
Orthologs
Location:
12q13.3
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (56994355..57000007)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (57388355..57390469)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 16 (all-trans) Neighboring gene retinol dehydrogenase 16 (all-trans) pseudogene Neighboring gene HBcAg-binding protein Neighboring gene zinc finger and BTB domain containing 39 Neighboring gene tachykinin 3 Neighboring gene myosin IA

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of G protein-coupled receptor 182 (GPR182) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...

Markers

Homology

Clone Names

  • MGC34399

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
adrenomedullin receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
G-protein coupled receptor 182
Names
adrenomedullin receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007264.3NP_009195.1  G-protein coupled receptor 182

    See identical proteins and their annotated locations for NP_009195.1

    Status: REVIEWED

    Source sequence(s)
    BC034761
    Consensus CDS
    CCDS8927.1
    UniProtKB/Swiss-Prot
    O15218
    Related
    ENSP00000300098, OTTHUMP00000244865, ENST00000300098, OTTHUMT00000411212
    Conserved Domains (1) summary
    pfam00001
    Location:88320
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    56994355..57000007
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537824.1XP_011536126.1  

    See identical proteins and their annotated locations for XP_011536126.1

    UniProtKB/Swiss-Prot
    O15218
    Conserved Domains (1) summary
    pfam00001
    Location:88320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_011537827.1XP_011536129.1  

    See identical proteins and their annotated locations for XP_011536129.1

    UniProtKB/Swiss-Prot
    O15218
    Conserved Domains (1) summary
    pfam00001
    Location:88320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011537826.1XP_011536128.1  

    See identical proteins and their annotated locations for XP_011536128.1

    UniProtKB/Swiss-Prot
    O15218
    Conserved Domains (1) summary
    pfam00001
    Location:88320
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_011537825.1XP_011536127.1  

    See identical proteins and their annotated locations for XP_011536127.1

    UniProtKB/Swiss-Prot
    O15218
    Conserved Domains (1) summary
    pfam00001
    Location:88320
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    57356105..57358219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)