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tnk2b tyrosine kinase, non-receptor, 2b [ Mastacembelus armatus (zig-zag eel) ]

Gene ID: 113133824, updated on 15-Mar-2024

Summary

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Gene symbol
tnk2b
Gene description
tyrosine kinase, non-receptor, 2b
See related
Ensembl:ENSMAMG00000018614
Gene type
protein coding
RefSeq status
MODEL
Organism
Mastacembelus armatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Anabantaria; Synbranchiformes; Mastacembelidae; Mastacembelus
Also known as
tnk2
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 17
Exon count:
23
Annotation release Status Assembly Chr Location
101 current fMasArm1.2 (GCF_900324485.2) 17 NC_046649.1 (8368697..8417149, complement)
100 previous assembly fMasArm1.1 (GCF_900324485.1) Unplaced Scaffold NW_020535907.1 (8368697..8417149, complement)

Chromosome 17 - NC_046649.1Genomic Context describing neighboring genes Neighboring gene WW domain-containing adapter protein with coiled-coil-like Neighboring gene pinopsin-like Neighboring gene transferrin receptor 1a Neighboring gene integrator complex subunit 15

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
activated CDC42 kinase 1
Names
tyrosine kinase non receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mastacembelus armatus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fMasArm1.2 Primary Assembly

Genomic

  1. NC_046649.1 Reference fMasArm1.2 Primary Assembly

    Range
    8368697..8417149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_026312753.1 → XP_026168538.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:445 → 494
    SH3; Src homology 3 domains
    cd14274
    Location:1158 → 1201
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1188 → 1227
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 437
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:497 → 564
    GTPase_binding; GTPase binding
    pfam11555
    Location:924 → 1014
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  2. XM_026312759.1 → XP_026168544.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:413 → 462
    SH3; Src homology 3 domains
    cd14274
    Location:1126 → 1169
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1156 → 1195
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:146 → 405
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:465 → 532
    GTPase_binding; GTPase binding
    pfam11555
    Location:892 → 982
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  3. XM_026312752.1 → XP_026168537.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:445 → 494
    SH3; Src homology 3 domains
    cd14274
    Location:1158 → 1201
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1188 → 1227
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 437
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:497 → 564
    GTPase_binding; GTPase binding
    pfam11555
    Location:924 → 1014
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  4. XM_026312751.1 → XP_026168536.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:445 → 494
    SH3; Src homology 3 domains
    cd14274
    Location:1158 → 1201
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1188 → 1227
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 437
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:497 → 564
    GTPase_binding; GTPase binding
    pfam11555
    Location:924 → 1014
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  5. XM_026312758.1 → XP_026168543.1  activated CDC42 kinase 1 isoform X5

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:6 → 67
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:413 → 462
    SH3; Src homology 3 domains
    cd14274
    Location:1126 → 1169
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1156 → 1195
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:146 → 405
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:465 → 532
    GTPase_binding; GTPase binding
    pfam11555
    Location:892 → 982
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  6. XM_026312749.1 → XP_026168534.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:445 → 494
    SH3; Src homology 3 domains
    cd14274
    Location:1158 → 1201
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1188 → 1227
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 437
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:497 → 564
    GTPase_binding; GTPase binding
    pfam11555
    Location:924 → 1014
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  7. XM_026312754.1 → XP_026168539.1  activated CDC42 kinase 1 isoform X2

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:444 → 493
    SH3; Src homology 3 domains
    cd14274
    Location:1157 → 1200
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1187 → 1226
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 436
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:496 → 563
    GTPase_binding; GTPase binding
    pfam11555
    Location:923 → 1013
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  8. XM_026312760.1 → XP_026168545.1  activated CDC42 kinase 1 isoform X6

    UniProtKB/TrEMBL
    A0A3Q3N636, A0A3Q3SNC5
    Related
    ENSMAMP00000027685.2, ENSMAMT00000028400.2
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:445 → 494
    SH3; Src homology 3 domains
    cd14274
    Location:1117 → 1160
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1147 → 1186
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 437
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:497 → 564
    GTPase_binding; GTPase binding
    pfam11555
    Location:883 → 973
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  9. XM_026312756.1 → XP_026168541.1  activated CDC42 kinase 1 isoform X4

    UniProtKB/TrEMBL
    A0A3Q3N636
    Related
    ENSMAMP00000027729.2, ENSMAMT00000028444.2
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:445 → 494
    SH3; Src homology 3 domains
    cd14274
    Location:1158 → 1201
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1188 → 1227
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 437
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:497 → 564
    GTPase_binding; GTPase binding
    pfam11555
    Location:924 → 1014
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  10. XM_026312748.1 → XP_026168533.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:445 → 494
    SH3; Src homology 3 domains
    cd14274
    Location:1158 → 1201
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1188 → 1227
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 437
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:497 → 564
    GTPase_binding; GTPase binding
    pfam11555
    Location:924 → 1014
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  11. XM_026312750.1 → XP_026168535.1  activated CDC42 kinase 1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:38 → 99
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:445 → 494
    SH3; Src homology 3 domains
    cd14274
    Location:1158 → 1201
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1188 → 1227
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:178 → 437
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:497 → 564
    GTPase_binding; GTPase binding
    pfam11555
    Location:924 → 1014
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  12. XM_026312755.2 → XP_026168540.1  activated CDC42 kinase 1 isoform X3

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:32 → 93
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:439 → 488
    SH3; Src homology 3 domains
    cd14274
    Location:1152 → 1195
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1182 → 1221
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:172 → 431
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:491 → 558
    GTPase_binding; GTPase binding
    pfam11555
    Location:918 → 1008
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  13. XM_026312762.2 → XP_026168547.1  activated CDC42 kinase 1 isoform X8

    UniProtKB/TrEMBL
    A0A3Q3N636
    Conserved Domains (7) summary
    cd09539
    Location:32 → 93
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:438 → 487
    SH3; Src homology 3 domains
    cd14274
    Location:1110 → 1153
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1140 → 1179
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:172 → 430
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:490 → 557
    GTPase_binding; GTPase binding
    pfam11555
    Location:876 → 966
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6

  14. XM_026312761.2 → XP_026168546.1  activated CDC42 kinase 1 isoform X7

    UniProtKB/TrEMBL
    A0A3Q3N5Z5, A0A3Q3N636
    Related
    ENSMAMP00000027694.2, ENSMAMT00000028409.2
    Conserved Domains (7) summary
    cd09539
    Location:32 → 93
    SAM_TNK-like; SAM domain of TNK(ACK)-like non-receptor tyrosine-protein kinases
    smart00326
    Location:439 → 488
    SH3; Src homology 3 domains
    cd14274
    Location:1111 → 1154
    UBA_ACK1; UBA domain found in activated Cdc42 kinase 1 (ACK1) and similar proteins
    cd14328
    Location:1141 → 1180
    UBA_TNK1; UBA domain found in non-receptor tyrosine-protein kinase TNK1 and similar proteins
    cd05040
    Location:172 → 431
    PTKc_Ack_like; Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase
    pfam09027
    Location:491 → 558
    GTPase_binding; GTPase binding
    pfam11555
    Location:877 → 967
    Inhibitor_Mig-6; EGFR receptor inhibitor Mig-6
Nucleotide Protein
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