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Abcg1 ATP-binding cassette, sub-family G (WHITE), member 1 [ Mus musculus (house mouse) ]

Gene ID: 11307, updated on 30-Oct-2014
Official Symbol
Abcg1provided by MGI
Official Full Name
ATP-binding cassette, sub-family G (WHITE), member 1provided by MGI
Primary source
MGI:MGI:107704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Abc8; White; AW413978
Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. The human protein is involved in macrophage cholesterol efflux and may regulate cellular lipid homeostasis in other cell types. [provided by RefSeq, Jul 2008]
See Abcg1 in Epigenomics, MapViewer
Location:
17; 17
Exon count:
15
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 17 NC_000083.6 (31057694..31117984)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene glucagon-like peptide 1 receptor Neighboring gene uromodulin-like 1 Neighboring gene trefoil factor 3, intestinal Neighboring gene trefoil factor 2 (spasmolytic protein 1)

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC141022

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ADP binding ISO
Inferred from Sequence Orthology
more info
 
ATP binding ISO
Inferred from Sequence Orthology
more info
 
ATPase activity IEA
Inferred from Electronic Annotation
more info
 
cholesterol transporter activity ISO
Inferred from Sequence Orthology
more info
 
glycoprotein transporter activity ISO
Inferred from Sequence Orthology
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phospholipid transporter activity ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
sterol-transporting ATPase activity ISO
Inferred from Sequence Orthology
more info
 
toxin transporter activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ATP catabolic process ISO
Inferred from Sequence Orthology
more info
 
amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol transport IDA
Inferred from Direct Assay
more info
PubMed 
glycoprotein transport ISO
Inferred from Sequence Orthology
more info
 
high-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of macrophage derived foam cell differentiation IC
Inferred by Curator
more info
PubMed 
phospholipid efflux ISO
Inferred from Sequence Orthology
more info
 
phospholipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cholesterol esterification IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to high density lipoprotein particle IDA
Inferred from Direct Assay
more info
PubMed 
response to lipid ISO
Inferred from Sequence Orthology
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
reverse cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
toxin transport ISO
Inferred from Sequence Orthology
more info
 
transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
recycling endosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
ATP-binding cassette sub-family G member 1
Names
ATP-binding cassette sub-family G member 1
white protein homolog
ATP-binding cassette 8
ATP-binding cassette transporter 8
ATP-binding cassette, subfamily G, member 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009593.2NP_033723.1  ATP-binding cassette sub-family G member 1

    See proteins identical to NP_033723.1

    Status: REVIEWED

    Source sequence(s)
    AC167247, AF323659, AK037433, BY296839, CO431055, CV558133
    Consensus CDS
    CCDS28602.1
    UniProtKB/TrEMBL
    Q0VDW9
    UniProtKB/Swiss-Prot
    Q64343
    Conserved Domains (3) summary
    cd03213
    Location:74299
    ABCG_EPDR; Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
    TIGR00955
    Location:60666
    3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
    pfam01061
    Location:391602
    ABC2_membrane; ABC-2 type transporter

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000083.6 

    Range
    31057694..31117984
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000039.1 

    Range
    31974265..32035260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)