PLCD3 phospholipase C, delta 3 [Homo sapiens] - Gene

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Summary

Official Symbol: PLCD3provided by HGNC
Official Full Name: phospholipase C, delta 3provided by HGNC
Primary source: HGNC:9061
See related: Ensembl:ENSG00000161714; HPRD:07146; MIM:608795
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MGC71172
Summary: This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 17q21.31

Sequence :: Chromosome: 17; NC_000017.10 (43189008..43209891, complement)

See PLCD3 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Common variants in or near FGF5, CYP17A1 and MTHFR genes are associated with blood pressure and hypertension in Chinese Hans.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Data are consistent with the idea that phospholipase C d1 and d3 isoforms support the growth and migration of normal and neoplastic mammary epithelial cells in vitro.
Title: Expression and function of phospholipase C in breast carcinoma.
Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study identifies eight loci associated with blood pressure.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study identifies eight loci associated with blood pressure.

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells	PubMed
Tat	tat	HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Phospholipase C, delta 3	P12757	SKIL		HPRD	PubMed
BioGRID:125222	BioGRID:113164	UBC		BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
calcium ion binding	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
phosphatidylinositol phospholipase C activity	IEA Inferred from Electronic Annotation more info
signal transducer activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
angiogenesis	IEA Inferred from Electronic Annotation more info
intracellular signal transduction	IEA Inferred from Electronic Annotation more info
labyrinthine layer blood vessel development	IEA Inferred from Electronic Annotation more info
lipid catabolic process	IEA Inferred from Electronic Annotation more info
regulation of cell proliferation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cleavage furrow	IEA Inferred from Electronic Annotation more info
cytoplasm	IEA Inferred from Electronic Annotation more info
membrane	IEA Inferred from Electronic Annotation more info
membrane fraction	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Names: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3; PLC delta3; PLC-delta-3; phospholipase C-delta-3; phosphoinositide phospholipase C-delta-3; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3

NP_588614.1

EC 3.1.4.11

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_133373.3 → NP_588614.1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

Status: REVIEWED

Source sequence(s)

AC002117, BC072384, BU621728, DA128483

UniProtKB/Swiss-Prot

Q8N3E9

Related

ENSP00000313731, ENST00000322765

Conserved Domains (5) summary

pfam09279
Location:259 – 336
Blast Score: 245

efhand_like; Phosphoinositide-specific phospholipase C, efhand-like

cd00275
Location:660 – 787
Blast Score: 449

C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)

cd01248
Location:60 – 170
Blast Score: 285

PH_PLC; Phospholipase C (PLC) pleckstrin homology (PH) domain

cd08630
Location:336 – 631
Blast Score: 1237

PI-PLCc_delta3; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-delta3

PLN02228
Location:259 – 772
Blast Score: 691

PLN02228; Phosphoinositide phospholipase C

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

43189008..43209891, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

38952185..38972987, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC002117.2 (16631..26362)	None
genomic	AC142472.2 (20196..31193)	None
genomic	CH471178.2	EAW51544.1
		EAW51545.1
		EAW51546.1
		EAW51547.1
genomic	HB877192.1	CBF62945.1
genomic	HB895826.1	CBF74688.1
genomic	HC934601.1	CBU87821.1
genomic	HC953235.1	CBU96768.1
mRNA	AB075844.1	BAB85550.1
mRNA	AK074240.1	BAB85029.1
mRNA	AL834392.1	CAD39054.2
mRNA	BC010668.1	AAH10668.2
mRNA	BC072384.1	AAH72384.1
mRNA	BU621728.1	None
mRNA	DA128483.1	None