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CHRM2 cholinergic receptor muscarinic 2 [ Homo sapiens (human) ]

Gene ID: 1129, updated on 8-May-2016
Official Symbol
CHRM2provided by HGNC
Official Full Name
cholinergic receptor muscarinic 2provided by HGNC
Primary source
HGNC:HGNC:1951
See related
Ensembl:ENSG00000181072 HPRD:00328; MIM:118493; Vega:OTTHUMG00000155658
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HM2
Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
7q31-q35
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (136868652..137020255)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (136553399..136703720)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375524 Neighboring gene proteasome 26S subunit, ATPase 1 pseudogene 3 Neighboring gene uncharacterized LOC349160 Neighboring gene microRNA 490 Neighboring gene uncharacterized LOC105375525 Neighboring gene ribosomal protein L18 pseudogene 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.
NHGRI GWA Catalog
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
  • Arf6 trafficking events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 trafficking events, organism-specific biosystem
    Arf6 trafficking events
  • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
    Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Cholinergic synapse, organism-specific biosystem (from KEGG)
    Cholinergic synapse, organism-specific biosystemAcetylcholine (ACh) is a neurotransmitter widely distributed in the central (and also peripheral, autonomic and enteric) nervous system (CNS). In the CNS, ACh facilitates many functions, such as lear...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Muscarinic acetylcholine receptors, organism-specific biosystem (from REACTOME)
    Muscarinic acetylcholine receptors, organism-specific biosystemMuscarinic acetylcholine (mAChRs) receptors were so named because they are more sensitive to muscarine than to nicotine (Ishii M and Kurachi Y, 2006). Their counterparts are nicotinic acetylcholine r...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystemhttp://www.genome.jp/kegg/pathway/hsa/hsa04810.html
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton
  • SIDS Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    SIDS Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
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  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ43243, MGC120006, MGC120007

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled acetylcholine receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
asymmetric synapse IEA
Inferred from Electronic Annotation
more info
 
axon terminus IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
symmetric synapse IEA
Inferred from Electronic Annotation
more info
 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
muscarinic acetylcholine receptor M2
Names
7TM receptor
acetylcholine receptor, muscarinic 2
cholinergic receptor, muscarinic 2
cholinergic receptor, muscarinic 2, isoform a
muscarinic M2 receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011846.2 RefSeqGene

    Range
    5001..153373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_405

mRNA and Protein(s)

  1. NM_000739.2NP_000730.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_000730.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1 through 8 encode the same protein (isoform a).
    Source sequence(s)
    AF498916, AY034604, AY456129
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  2. NM_001006626.1NP_001006627.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 through 8 encode the same protein (isoform a).
    Source sequence(s)
    AF498916, AY219705, AY456129
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Related
    ENSP00000384401, OTTHUMP00000208394, ENST00000401861, OTTHUMT00000341012
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  3. NM_001006627.1NP_001006628.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006628.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 through 8 encode the same protein (isoform a).
    Source sequence(s)
    AF498916, AY219704, AY456129
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Related
    ENSP00000399745, OTTHUMP00000208393, ENST00000445907, OTTHUMT00000341010
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  4. NM_001006628.1NP_001006629.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1 through 8 encode the same protein (isoform a).
    Source sequence(s)
    AF498916, AY034605, AY456129
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  5. NM_001006629.1NP_001006630.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1 through 8 encode the same protein (isoform a).
    Source sequence(s)
    AF498916, AY219703, AY456129
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  6. NM_001006630.1NP_001006631.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006631.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 through 8 encode the same protein (isoform a).
    Source sequence(s)
    AF498916, AY034603, AY219704, AY456129
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q86SJ1
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  7. NM_001006631.1NP_001006632.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006632.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1 through 8 encode the same protein (isoform a).
    Source sequence(s)
    AF498916, AY456126, AY456129
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q6SL59
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  8. NM_001006632.1NP_001006633.1  muscarinic acetylcholine receptor M2

    See identical proteins and their annotated locations for NP_001006633.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1 through 8 encode the same protein (isoform a).
    Source sequence(s)
    AF498916, AY456125, AY456129
    Consensus CDS
    CCDS5843.1
    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0, Q6SL56, Q6SL59
    Related
    ENSP00000319984, OTTHUMP00000208396, ENST00000320658, OTTHUMT00000341016
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

    Range
    136868652..137020255
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515771.1XP_011514073.1  

    See identical proteins and their annotated locations for XP_011514073.1

    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  2. XM_011515770.1XP_011514072.1  

    See identical proteins and their annotated locations for XP_011514072.1

    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein
  3. XM_011515769.1XP_011514071.1  

    See identical proteins and their annotated locations for XP_011514071.1

    UniProtKB/Swiss-Prot
    P08172
    UniProtKB/TrEMBL
    A4D1Q0
    Conserved Domains (2) summary
    pfam00001
    Location:46440
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam15427
    Location:255385
    S100PBPR; S100P-binding protein

Alternate CHM1_1.1

Genomic

  1. NC_018918.2 Alternate CHM1_1.1

    Range
    136487338..136635497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006633.1: Suppressed sequence

    Description
    NM_001006633.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript and the protein.