CCDC101 coiled-coil domain containing 101 [Homo sapiens] - Gene

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Summary

Official Symbol: CCDC101provided by HGNC
Official Full Name: coiled-coil domain containing 101provided by HGNC
Primary source: HGNC:25156
See related: Ensembl:ENSG00000176476; HPRD:13996; MIM:613374; Vega:OTTHUMG00000131763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: SGF29; STAF36; FLJ32446
Summary: CCDC101 is a subunit of 2 histone acetyltransferase complexes: the ADA2A (TADA2A; MIM 602276)-containing (ATAC) complex and the SPT3 (SUPT3H; MIM 602947)-TAF9 (MIM 600822)-GCN5 (KAT2A; MIM 602301)/PCAF (KAT2B; MIM 602303) acetylase (STAGA) complex. Both of these complexes contain either GCN5 or PCAF, which are paralogous acetyltransferases (Wang et al., 2008 [PubMed 18838386]).[supplied by OMIM, Apr 2010]

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Genomic context

Location :: 16p11.2

Sequence :: Chromosome: 16; NC_000016.9 (28565249..28603111)

See CCDC101 in Epigenomics, MapViewer

Chromosome 16 - NC_000016.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Common variants at five new loci associated with early-onset inflammatory bowel disease.

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Products	Interactant	Other Gene	Source	Pubs	Description
Q96ES7	Hypothetical protein FLJ25770	CCDC158	HPRD	PubMed
Q96ES7	P19012	KRT15	HPRD	PubMed
Q96ES7	O75528	TADA3	HPRD	PubMed
BioGRID:125213	BioGRID:112221	ATXN7	BioGRID	PubMed	Affinity Capture-Western
BioGRID:125213	BioGRID:130969	CCDC158	BioGRID	PubMed	Two-hybrid
BioGRID:125213	BioGRID:231562	Edc4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:125213	BioGRID:32711	HHT1	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:125213	BioGRID:35796	HHT2	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:125213	BioGRID:110064	KRT15	BioGRID	PubMed	Two-hybrid
BioGRID:125213	BioGRID:211904	Ndc80	BioGRID	PubMed	Affinity Capture-MS
BioGRID:125213	BioGRID:112734	TADA2A	BioGRID	PubMed	Affinity Capture-MS; Affinity Capture-Western
BioGRID:125213	BioGRID:115737	TADA3	BioGRID	PubMed	Two-hybrid
BioGRID:125213	BioGRID:113900	TRRAP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:125213	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:125213	BioGRID:116914	USP22	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
methylated histone residue binding	IDA Inferred from Direct Assay more info

Process	Evidence Code	Pubs
chromatin modification	IEA Inferred from Electronic Annotation more info
establishment of protein localization to chromatin	TAS Traceable Author Statement more info
histone H3 acetylation	IDA Inferred from Direct Assay more info	PubMed
regulation of transcription, DNA-dependent	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
Ada2/Gcn5/Ada3 transcription activator complex	IDA Inferred from Direct Assay more info	PubMed
SAGA-type complex	IDA Inferred from Direct Assay more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: SAGA-associated factor 29 homolog

Names: SAGA-associated factor 29 homolog; coiled-coil domain-containing protein 101

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138414.2 → NP_612423.1 SAGA-associated factor 29 homolog

Status: VALIDATED

Source sequence(s)

AA132314, AA132818, BC011981

Consensus CDS

CCDS10635.1

UniProtKB/Swiss-Prot

Q96ES7

Related

ENSP00000316114, OTTHUMP00000162566, ENST00000317058, OTTHUMT00000254691

Conserved Domains (1) summary

pfam07039
Location:158 – 289
Blast Score: 517

DUF1325; SGF29 tudor-like domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000016.9 Reference GRCh37.p5 Primary Assembly

Range

28565249..28603111

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000148.1 Alternate HuRef

Range

26590877..26628721

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC020765.8 (92401..130253)	None
genomic	CH471279.1	EAW52272.1
mRNA	AA132314.1	None
mRNA	AA132818.1	None
mRNA	AK057008.1	BAB71340.1
mRNA	BC011981.1	AAH11981.1