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HSPG2 heparan sulfate proteoglycan 2 [ Puma concolor (puma) ]

Gene ID: 112862168, updated on 15-Mar-2024

Summary

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Gene symbol
HSPG2
Gene description
heparan sulfate proteoglycan 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Puma concolor
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
97
Annotation release Status Assembly Chr Location
100 current PumCon1.0 (GCF_003327715.1) Unplaced Scaffold NW_020338243.1 (15845359..15942136, complement)

NW_020338243.1Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 48 Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene chymotrypsin-like elastase family member 3B Neighboring gene SCAN domain-containing protein 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020338243 Unplaced Scaffold Reference PumCon1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
basement membrane-specific heparan sulfate proteoglycan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Puma concolor Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference PumCon1.0 Primary Assembly

Genomic

  1. NW_020338243.1 Reference PumCon1.0 Primary Assembly

    Range
    15845359..15942136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025925406.1 → XP_025781191.1  basement membrane-specific heparan sulfate proteoglycan core protein

    UniProtKB/TrEMBL
    A0A6P6HZS1
    Conserved Domains (19) summary
    cd05743
    Location:415 → 492
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan, also known as HSPG2, and similar domains
    cd05754
    Location:1757 → 1842
    Ig_Perlecan_like; Igmmunoglobulin (Ig)-like domain found in Perlecan and similar proteins
    smart00180
    Location:1599 → 1647
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00200
    Location:74 → 188
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:584 → 711
    LamB; Laminin B domain
    smart00409
    Location:2823 → 2899
    IG; Immunoglobulin
    smart00410
    Location:3293 → 3370
    IG_like; Immunoglobulin like
    cd00054
    Location:3840 → 3869
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:758 → 800
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4191 → 4350
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:279 → 313
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07679
    Location:1942 → 2028
    I-set; Immunoglobulin I-set domain
    pfam00053
    Location:873 → 915
    Laminin_EGF; Laminin EGF domain
    pfam00008
    Location:4096 → 4126
    EGF; EGF-like domain
    pfam00052
    Location:984 → 1118
    Laminin_B; Laminin B (Domain IV)
    pfam13927
    Location:2619 → 2689
    Ig_3; Immunoglobulin domain
    cd00096
    Location:2542 → 2601
    Ig; Immunoglobulin domain
    cl11960
    Location:3405 → 3471
    Ig; Immunoglobulin domain
    cl28434
    Location:3481 → 3560
    I-set; Immunoglobulin I-set domain
Nucleotide Protein
Heading Accession and Version

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