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PTPN3 protein tyrosine phosphatase non-receptor type 3 [ Puma concolor (puma) ]

Gene ID: 112861904, updated on 15-Mar-2024

Summary

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Gene symbol
PTPN3
Gene description
protein tyrosine phosphatase non-receptor type 3
Gene type
protein coding
RefSeq status
MODEL
Organism
Puma concolor
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
25
Annotation release Status Assembly Chr Location
100 current PumCon1.0 (GCF_003327715.1) Unplaced Scaffold NW_020337930.1 (20523281..20601066)

NW_020337930.1Genomic Context describing neighboring genes Neighboring gene A-kinase anchoring protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene paralemmin 2 Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene ferric chelate reductase 1 like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020337930 Unplaced Scaffold Reference PumCon1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Puma concolor Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference PumCon1.0 Primary Assembly

Genomic

  1. NW_020337930.1 Reference PumCon1.0 Primary Assembly

    Range
    20523281..20601066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025925195.1 → XP_025780980.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

    UniProtKB/TrEMBL
    A0A6P6HYU4
    Conserved Domains (4) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:672 → 899
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:508 → 595
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

  2. XM_025925130.1 → XP_025780915.1  tyrosine-protein phosphatase non-receptor type 3 isoform X1

    UniProtKB/TrEMBL
    A0A6P6HYM8
    Conserved Domains (4) summary
    smart00295
    Location:30 → 222
    B41; Band 4.1 homologues
    cd00047
    Location:627 → 854
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    cd00992
    Location:463 → 550
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd13189
    Location:216 → 309
    FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
Nucleotide Protein
Heading Accession and Version

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