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PREX2 phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2 [ Puma concolor (puma) ]

Gene ID: 112859336, updated on 15-Mar-2024

Summary

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Gene symbol
PREX2
Gene description
phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Puma concolor
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Puma
Orthologs
human mouse all
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Genomic context

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See PREX2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
39
Annotation release Status Assembly Chr Location
100 current PumCon1.0 (GCF_003327715.1) Unplaced Scaffold NW_020339263.1 (65457669..65674887, complement)

NW_020339263.1Genomic Context describing neighboring genes Neighboring gene chromosome unknown C8orf34 homolog Neighboring gene THUMP domain-containing protein 3 pseudogene Neighboring gene U6 spliceosomal RNA Neighboring gene tubulin alpha-1A chain-like Neighboring gene carboxypeptidase A6

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020339263 Unplaced Scaffold Reference PumCon1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Puma concolor Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference PumCon1.0 Primary Assembly

Genomic

  1. NW_020339263.1 Reference PumCon1.0 Primary Assembly

    Range
    65457669..65674887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025922562.1 → XP_025778347.1  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein

    UniProtKB/TrEMBL
    A0A6P6HRD6
    Conserved Domains (5) summary
    cd00992
    Location:632 → 699
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd04439
    Location:337 → 417
    DEP_1_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 1 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd04440
    Location:429 → 521
    DEP_2_P-Rex; DEP (Dishevelled, Egl-10, and Pleckstrin) domain 2 found in P-Rex-like proteins. The P-Rex family is the guanine-nucleotide exchange factor (GEF) for the small GTPase Rac that contains an N-terminal RhoGEF domain, two DEP and PDZ domains. Rac-GEF ...
    cd01224
    Location:173 → 319
    PH_Collybistin_ASEF; Collybistin/APC-stimulated guanine nucleotide exchange factor pleckstrin homology (PH) domain
    pfam00621
    Location:19 → 167
    RhoGEF; RhoGEF domain
Nucleotide Protein
Heading Accession and Version

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