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ITSN2 intersectin 2 [ Callorhinus ursinus (northern fur seal) ]

Gene ID: 112820820, updated on 15-Mar-2024

Summary

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Gene symbol
ITSN2
Gene description
intersectin 2
See related
EnsemblRapid:ENSCURG00000001691
Gene type
protein coding
RefSeq status
MODEL
Organism
Callorhinus ursinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Otariidae; Callorhinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
42
Annotation release Status Assembly Chr Location
100 current ASM326570v1 (GCF_003265705.1) Unplaced Scaffold NW_020312817.1 (19849721..19987549, complement)

NW_020312817.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 228 member B Neighboring gene profilin family member 4 Neighboring gene family with sequence similarity 228 member A Neighboring gene U6 spliceosomal RNA Neighboring gene U4 spliceosomal RNA Neighboring gene basic proline-rich protein-like Neighboring gene uncharacterized LOC112820821 Neighboring gene nuclear receptor coactivator 1 Neighboring gene 40S ribosomal protein SA-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020312817 Unplaced Scaffold Reference ASM326570v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables molecular adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in clathrin-dependent synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in endosomal transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of Rho protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intracellular vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
intersectin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Callorhinus ursinus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM326570v1 Primary Assembly

Genomic

  1. NW_020312817.1 Reference ASM326570v1 Primary Assembly

    Range
    19849721..19987549 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025867833.1 → XP_025723618.1  intersectin-2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q7NQM2
    Conserved Domains (11) summary
    cd08375
    Location:1519 → 1653
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:721 → 777
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:862 → 913
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:945 → 996
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1017 → 1075
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1094 → 1147
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1178 → 1358
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90 → 207
    SOBP; Sine oculis-binding protein
    pfam16652
    Location:1376 → 1518
    PH_13; Pleckstrin homology domain
    cl25732
    Location:355 → 698
    SMC_N; RecF/RecN/SMC N terminal domain

  2. XM_025867829.1 → XP_025723614.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q7NQV1
    Conserved Domains (11) summary
    cd08375
    Location:1553 → 1687
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:49 → 141
    EH; Eps15 homology domain
    cd11988
    Location:755 → 811
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:896 → 947
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:979 → 1030
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1051 → 1109
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1128 → 1181
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1212 → 1392
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:124 → 241
    SOBP; Sine oculis-binding protein
    pfam16652
    Location:1410 → 1552
    PH_13; Pleckstrin homology domain
    cl25732
    Location:389 → 732
    SMC_N; RecF/RecN/SMC N terminal domain

  3. XM_025867832.1 → XP_025723617.1  intersectin-2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q7NQM2
    Conserved Domains (11) summary
    cd08375
    Location:1519 → 1653
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:721 → 777
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:862 → 913
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:945 → 996
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1017 → 1075
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1094 → 1147
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1178 → 1358
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90 → 207
    SOBP; Sine oculis-binding protein
    pfam16652
    Location:1376 → 1518
    PH_13; Pleckstrin homology domain
    cl25732
    Location:355 → 698
    SMC_N; RecF/RecN/SMC N terminal domain

  4. XM_025867828.1 → XP_025723613.1  intersectin-2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q7NQV1
    Conserved Domains (11) summary
    cd08375
    Location:1553 → 1687
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:49 → 141
    EH; Eps15 homology domain
    cd11988
    Location:755 → 811
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:896 → 947
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:979 → 1030
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1051 → 1109
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1128 → 1181
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1212 → 1392
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:124 → 241
    SOBP; Sine oculis-binding protein
    pfam16652
    Location:1410 → 1552
    PH_13; Pleckstrin homology domain
    cl25732
    Location:389 → 732
    SMC_N; RecF/RecN/SMC N terminal domain

  5. XM_025867830.1 → XP_025723615.1  intersectin-2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q7NPQ8
    Conserved Domains (11) summary
    cd08375
    Location:1549 → 1683
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:49 → 141
    EH; Eps15 homology domain
    cd11988
    Location:755 → 811
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:896 → 947
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:979 → 1030
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1051 → 1109
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1124 → 1177
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1208 → 1388
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:124 → 241
    SOBP; Sine oculis-binding protein
    pfam16652
    Location:1406 → 1548
    PH_13; Pleckstrin homology domain
    cl25732
    Location:389 → 732
    SMC_N; RecF/RecN/SMC N terminal domain

  6. XM_025867831.1 → XP_025723616.1  intersectin-2 isoform X3

    UniProtKB/TrEMBL
    A0A3Q7Q5V7
    Related
    ENSCURP00000002466.1, ENSCURT00000003016.1
    Conserved Domains (11) summary
    cd08375
    Location:1515 → 1649
    C2_Intersectin; C2 domain present in Intersectin
    smart00027
    Location:15 → 107
    EH; Eps15 homology domain
    cd11988
    Location:721 → 777
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:862 → 913
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:945 → 996
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1017 → 1075
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1090 → 1143
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    smart00325
    Location:1174 → 1354
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    pfam15279
    Location:90 → 207
    SOBP; Sine oculis-binding protein
    pfam16652
    Location:1372 → 1514
    PH_13; Pleckstrin homology domain
    cl25732
    Location:355 → 698
    SMC_N; RecF/RecN/SMC N terminal domain

  7. XM_025867834.1 → XP_025723619.1  intersectin-2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q7NQV6
    Conserved Domains (8) summary
    smart00027
    Location:49 → 141
    EH; Eps15 homology domain
    cd11988
    Location:755 → 811
    SH3_Intersectin2_1; First Src homology 3 domain (or SH3A) of Intersectin-2
    cd11990
    Location:896 → 947
    SH3_Intersectin2_2; Second Src homology 3 domain (or SH3B) of Intersectin-2
    cd11992
    Location:979 → 1030
    SH3_Intersectin2_3; Third Src homology 3 domain (or SH3C) of Intersectin-2
    cd11994
    Location:1051 → 1109
    SH3_Intersectin2_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-2
    cd11996
    Location:1124 → 1177
    SH3_Intersectin2_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-2
    pfam15279
    Location:124 → 241
    SOBP; Sine oculis-binding protein
    cl25732
    Location:389 → 732
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
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