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ERBB2 erb-b2 receptor tyrosine kinase 2 [ Callorhinus ursinus (northern fur seal) ]

Gene ID: 112814066, updated on 11-Apr-2024

Summary

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Gene symbol
ERBB2
Gene description
erb-b2 receptor tyrosine kinase 2
See related
EnsemblRapid:ENSCURG00000024871
Gene type
protein coding
RefSeq status
MODEL
Organism
Callorhinus ursinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Pinnipedia; Otariidae; Callorhinus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
27
Annotation release Status Assembly Chr Location
100 current ASM326570v1 (GCF_003265705.1) Unplaced Scaffold NW_020313165.1 (8530547..8553503)

NW_020313165.1Genomic Context describing neighboring genes Neighboring gene phenylethanolamine N-methyltransferase Neighboring gene post-GPI attachment to proteins phospholipase 3 Neighboring gene 40S ribosomal protein S3a-like Neighboring gene migration and invasion enhancer 1 Neighboring gene growth factor receptor bound protein 7

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_020313165 Unplaced Scaffold Reference ASM326570v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in neuron differentiation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in basal plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
receptor tyrosine-protein kinase erbB-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Callorhinus ursinus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM326570v1 Primary Assembly

Genomic

  1. NW_020313165.1 Reference ASM326570v1 Primary Assembly

    Range
    8530547..8553503
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025859386.1 → XP_025715171.1  receptor tyrosine-protein kinase erbB-2

    UniProtKB/TrEMBL
    A0A3Q7PH14
    Related
    ENSCURP00000040533.1, ENSCURT00000046118.1
    Conserved Domains (6) summary
    cd12094
    Location:641 → 684
    TM_ErbB2; Transmembrane domain of ErbB2, a Protein Tyrosine Kinase
    PRK10263
    Location:971 → 1192
    PRK10263; DNA translocase FtsK; Provisional
    cd05109
    Location:712 → 990
    PTKc_HER2; Catalytic domain of the Protein Tyrosine Kinase, HER2
    pfam00757
    Location:189 → 338
    Furin-like; Furin-like cysteine rich region
    pfam14843
    Location:511 → 643
    GF_recep_IV; Growth factor receptor domain IV
    pfam01030
    Location:53 → 171
    Recep_L_domain; Receptor L domain
Nucleotide Protein
Heading Accession and Version

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