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    STX1B syntaxin 1B [ Homo sapiens ]

    Gene ID: 112755, updated on 12-May-2012

    Summary

    Official Symbol
    STX1Bprovided by HGNC
    Official Full Name
    syntaxin 1Bprovided by HGNC
    Primary source
    HGNC:18539
    See related
    Ensembl:ENSG00000099365; HPRD:18126; MIM:601485; Vega:OTTHUMG00000132391
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STX1B1; STX1B2
    Summary
    Syntaxins are cellular receptors for transport vesicles (see MIM 603765). One of these proteins, designated syntaxin 1B (STX1B), is directly implicated in the process of calcium-dependent synaptic transmission in rat brain (Smirnova et al., 1993 [PubMed 8105537]). The expression of this protein is transiently induced by long-term potentiation of synaptic responses in the rat hippocampus. The protein may play an important role in the excitatory pathway of synaptic transmission, which is known to be implicated in several neurologic diseases.[supplied by OMIM, Nov 2010]

    Genomic context

    Location :
    16p11.2
    Sequence :
    Chromosome: 16; NC_000016.9 (31000577..31021829, complement)
    See STX1B in Epigenomics, MapViewer

    Chromosome 16 - NC_000016.9Genomic Context describing neighboring genes Neighboring gene SET domain containing 1A Neighboring gene hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 Neighboring gene cardiotrophin 2, pseudogene Neighboring gene syntaxin 4 Neighboring gene zinc finger protein 668

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q15531 P61764 STXBP1    HPRD  PubMed  
    Q15531 O14795 UNC13B    HPRD  PubMed  
    Q15531 P23763 VAMP1    HPRD  PubMed  
    Q15531 P63027 VAMP2    HPRD  PubMed  
    Q15531 Q9BV40 VAMP8    HPRD  PubMed  
    BioGRID:125203 BioGRID:114303 SNAP23    BioGRID  PubMed Reconstituted Complex 
    BioGRID:125203 BioGRID:112681 STXBP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:125203 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:125203 BioGRID:115759 UNC13B    BioGRID  PubMed Co-fractionation; Two-hybrid 
    BioGRID:125203 BioGRID:112710 VAMP1    BioGRID  PubMed Two-hybrid 
    BioGRID:125203 BioGRID:112711 VAMP2    BioGRID  PubMed Two-hybrid 
    BioGRID:125203 BioGRID:114650 VAPB    BioGRID  PubMed Reconstituted Complex 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Botulinum neurotoxicity, organism-specific biosystem (from REACTOME)
      Botulinum neurotoxicity, organism-specific biosystemBotulism, caused by botulinum neurotoxin (BoNT), is characterized by descending flaccid paralysis as a result of inhibition of neurotransmitter release at the neuromuscular junction - NMJ (Turton et ...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • Proteolytic cleavage of SNARE complex proteins, organism-specific biosystem (from REACTOME)
      Proteolytic cleavage of SNARE complex proteins, organism-specific biosystemVAMP/synaptobrevin, SNAP-25 and syntaxin are important for synaptic vesicle fusion at the nerve terminal. These proteins constitute the synaptic members of SNARE family (soluble N-ethylmaleimide-sen...
    • SNARE interactions in vesicular transport, organism-specific biosystem (from KEGG)
      SNARE interactions in vesicular transport, organism-specific biosystem
      SNARE interactions in vesicular transport
    • SNARE interactions in vesicular transport, conserved biosystem (from KEGG)
      SNARE interactions in vesicular transport, conserved biosystem
      SNARE interactions in vesicular transport
    • Synaptic vesicle cycle, organism-specific biosystem (from KEGG)
      Synaptic vesicle cycle, organism-specific biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...
    • Synaptic vesicle cycle, conserved biosystem (from KEGG)
      Synaptic vesicle cycle, conserved biosystemCommunication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular ligand-gated ion channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular-glutamate-gated ion channel activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    transport TAS
    Traceable Author Statement
    more info
    PubMed 
    vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    integral to plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane fraction IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    syntaxin-1B
    Names
    syntaxin-1B
    FP17469
    syntaxin 1B1
    syntaxin 1B2
    syntaxin-1B1
    syntaxin-1B2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_052874.3NP_443106.1  syntaxin-1B

      Status: VALIDATED

      Source sequence(s)
      AC135048, AY028792, BX102270
      Consensus CDS
      CCDS10699.1
      UniProtKB/Swiss-Prot
      P61266
      Related
      ENSP00000215095, OTTHUMP00000163224, ENST00000215095, OTTHUMT00000255521
      Conserved Domains (2) summary
      cd00179
      Location:29180
      Blast Score: 374
      SynN; Syntaxin N-terminus domain; syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane; they are a family of receptors for intracellular transport vesicles; each target membrane may ...
      cd00193
      Location:194253
      Blast Score: 132
      t_SNARE; Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein (SNAP) REceptor domain; these alpha-helical motifs form twisted and parallel heterotetrameric helix bundles; the core complex contains one helix from a protein that is anchored in ...

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000016.9 Reference GRCh37.p5 Primary Assembly

      Range
      31000577..31021829, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000148.1 Alternate HuRef

      Range
      28563033..28574857, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC135048.2 None
    genomic AC135050.3 (62607..66330) None
    genomic CH471192.1 EAW52178.1
    mRNA AY028792.1 AAK27267.1
    mRNA AY203924.1 AAP34447.1
    mRNA AY995211.1 AAY45889.1
    mRNA BC038359.1 None
    mRNA BC062298.1 AAH62298.1
    mRNA BX102270.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61266.1 GenPept UniProtKB/Swiss-Prot:P61266
    Q2VPS2 GenPept UniProtKB/TrEMBL:Q2VPS2
    Q6XYE6 GenPept UniProtKB/TrEMBL:Q6XYE6

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