Format

Send to:

Choose Destination

IL17F interleukin 17F [ Homo sapiens (human) ]

Gene ID: 112744, updated on 8-May-2016
Official Symbol
IL17Fprovided by HGNC
Official Full Name
interleukin 17Fprovided by HGNC
Primary source
HGNC:HGNC:16404
See related
Ensembl:ENSG00000112116 HPRD:16224; MIM:606496; Vega:OTTHUMG00000014845
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ML1; ML-1; CANDF6; IL-17F
Summary
The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1. [provided by RefSeq, Jul 2008]
Orthologs
Location:
6p12
Exon count:
4
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (52236681..52245689, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (52101484..52109298, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene interleukin 17A Neighboring gene uncharacterized LOC102724327 Neighboring gene uncharacterized LOC105375088 Neighboring gene solute carrier family 25 member 20 pseudogene 1 Neighboring gene minichromosome maintenance complex component 3

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Candidiasis, familial, 6
MedGen: C3151405 OMIM: 613956 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.
NHGRI GWA Catalog
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • IL17 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL17 signaling pathway, organism-specific biosystemInterleukin 17 is a family of cytokines that acts as potent mediators in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site ...
  • IL23-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL23-mediated signaling events, organism-specific biosystem
    IL23-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory bowel disease (IBD), organism-specific biosystem (from KEGG)
    Inflammatory bowel disease (IBD), organism-specific biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Inflammatory bowel disease (IBD), conserved biosystem (from KEGG)
    Inflammatory bowel disease (IBD), conserved biosystemInflammatory bowel disease (IBD), which includes Crohn disease (CD) and ulcerative colitis (UC), is characterized by chronic inflammation of the gastrointestinal tract due to environmental and geneti...
  • Interleukin-17 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-17 signaling, organism-specific biosystemInterleukin-17 (IL17) is a family of cytokines (Kawaguchi et al. 2004, Gu et al. 2013). IL17A, the founding member of the family, member of this family, is able to induce the production of other cyt...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
cytokine binding IDA
Inferred from Direct Assay
more info
PubMed 
cytokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
interleukin-17F
Names
cytokine ML-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031869.1 RefSeqGene

    Range
    5001..12815
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_356

mRNA and Protein(s)

  1. NM_052872.3NP_443104.1  interleukin-17F precursor

    See identical proteins and their annotated locations for NP_443104.1

    Status: REVIEWED

    Source sequence(s)
    AF332389, BC070124
    Consensus CDS
    CCDS4938.1
    UniProtKB/Swiss-Prot
    Q96PD4
    Related
    ENSP00000337432, OTTHUMP00000016602, ENST00000336123, OTTHUMT00000040901
    Conserved Domains (1) summary
    pfam06083
    Location:76156
    IL17; Interleukin-17

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    52236681..52245689 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514276.1XP_011512578.1  

    See identical proteins and their annotated locations for XP_011512578.1

    UniProtKB/Swiss-Prot
    Q96PD4
    Conserved Domains (1) summary
    pfam06083
    Location:76156
    IL17; Interleukin-17

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    52103743..52111557 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)