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GPR176 G protein-coupled receptor 176 [ Homo sapiens (human) ]

Gene ID: 11245, updated on 26-May-2016
Official Symbol
GPR176provided by HGNC
Official Full Name
G protein-coupled receptor 176provided by HGNC
Primary source
HGNC:HGNC:32370
See related
Ensembl:ENSG00000166073 HPRD:13597; MIM:612183; Vega:OTTHUMG00000129873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB-954
Summary
Members of the G protein-coupled receptor family, such as GPR176, are cell surface receptors involved in responses to hormones, growth factors, and neurotransmitters (Hata et al., 1995 [PubMed 7893747]).[supplied by OMIM, Jul 2008]
Orthologs
Location:
15q14-q15.1
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (39799022..39920892, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40091223..40213093, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370785 Neighboring gene fibrous sheath interacting protein 1 Neighboring gene uncharacterized LOC105370941 Neighboring gene uncharacterized LOC105370786 Neighboring gene uncharacterized LOC100505534 Neighboring gene eukaryotic translation initiation factor 2 alpha kinase 4 Neighboring gene H3 histone, family 3A pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCRs, Other, organism-specific biosystem (from WikiPathways)
    GPCRs, Other, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
probable G-protein coupled receptor 176

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271854.1NP_001258783.1  probable G-protein coupled receptor 176 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC023908, BC067106, CB106487, D38449
    Consensus CDS
    CCDS61589.1
    UniProtKB/Swiss-Prot
    Q14439
    UniProtKB/TrEMBL
    J3KNC6
    Related
    ENSP00000299092, OTTHUMP00000248386, ENST00000299092, OTTHUMT00000418451
    Conserved Domains (1) summary
    pfam00001
    Location:78318
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_001271855.1NP_001258784.1  probable G-protein coupled receptor 176 isoform 3

    See identical proteins and their annotated locations for NP_001258784.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC023908, AK302715, BC067106, CB106487
    Consensus CDS
    CCDS61588.1
    UniProtKB/Swiss-Prot
    Q14439
    UniProtKB/TrEMBL
    B4DZ23
    Related
    ENSP00000439361, ENST00000543580
    Conserved Domains (1) summary
    pfam00001
    Location:19274
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_007223.2NP_009154.1  probable G-protein coupled receptor 176 isoform 1

    See identical proteins and their annotated locations for NP_009154.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC023908, BC067106, CB106487, D38449
    Consensus CDS
    CCDS10051.1
    UniProtKB/Swiss-Prot
    Q14439
    UniProtKB/TrEMBL
    H9NIL9
    Related
    ENSP00000453076, OTTHUMP00000160314, ENST00000561100, OTTHUMT00000252117
    Conserved Domains (1) summary
    pfam00001
    Location:64319
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    39799022..39920892 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011521168.1XP_011519470.1  

    See identical proteins and their annotated locations for XP_011519470.1

    Conserved Domains (1) summary
    pfam00001
    Location:32287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. XM_005254139.2XP_005254196.2  

    Conserved Domains (1) summary
    pfam00001
    Location:39294
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. XM_011521167.1XP_011519469.1  

    See identical proteins and their annotated locations for XP_011519469.1

    Conserved Domains (1) summary
    pfam00001
    Location:32287
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  4. XM_006720379.2XP_006720442.1  

    See identical proteins and their annotated locations for XP_006720442.1

    Conserved Domains (1) summary
    pfam00001
    Location:3156
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  5. XM_011521169.1XP_011519471.1  

    See identical proteins and their annotated locations for XP_011519471.1

    Conserved Domains (1) summary
    pfam00001
    Location:3156
    7tm_1; 7 transmembrane receptor (rhodopsin family)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    40210585..40332721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)