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RNF24 ring finger protein 24 [ Homo sapiens (human) ]

Gene ID: 11237, updated on 26-May-2016
Official Symbol
RNF24provided by HGNC
Official Full Name
ring finger protein 24provided by HGNC
Primary source
HGNC:HGNC:13779
See related
Ensembl:ENSG00000101236 HPRD:10198; MIM:612489; Vega:OTTHUMG00000031770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G1L
Summary
This gene encodes an integral membrane protein that contains a RING-type zinc finger. The encoded protein may interact with multiple transient receptor potential cation channel subfamily C (TRPC) proteins and regulate the trafficking and insertion of these proteins into the plasma membrane. [provided by RefSeq, Mar 2016]
Orthologs
Location:
20p13
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 20 NC_000020.11 (3929918..4015569, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (3912068..3996216, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene mitochondrial antiviral signaling protein Neighboring gene pantothenate kinase 2 Neighboring gene microRNA 103a-2 Neighboring gene microRNA 103b-2 Neighboring gene ferritin, light polypeptide pseudogene 3 Neighboring gene ribosomal protein L21 pseudogene 2

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
protein ubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134337.2NP_001127809.1  RING finger protein 24 isoform 1

    See identical proteins and their annotated locations for NP_001127809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, BC039584, BQ181223, CD367454, HY140488
    Consensus CDS
    CCDS13074.1
    UniProtKB/Swiss-Prot
    Q9Y225
    Related
    ENSP00000351166, OTTHUMP00000161029, ENST00000358395, OTTHUMT00000252862
    Conserved Domains (1) summary
    cd00162
    Location:78122
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. NM_001134338.2NP_001127810.1  RING finger protein 24 isoform 2

    See identical proteins and their annotated locations for NP_001127810.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains a different segment for its 5' UTR and includes an alternate segment which uses an upstream AUG codon, compared to variant 1. The resulting isoform (2) has a longer N-terminus compared to isoform 1.
    Source sequence(s)
    AL031670, BC000213, BQ181223, CD367454, HY140488
    Consensus CDS
    CCDS46577.1
    UniProtKB/Swiss-Prot
    Q9Y225
    Related
    ENSP00000444711, OTTHUMP00000274066, ENST00000545616, OTTHUMT00000471914
    Conserved Domains (1) summary
    cd00162
    Location:99143
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. NM_001321749.1NP_001308678.1  RING finger protein 24 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, BQ181223, HY050527, HY140488
    Conserved Domains (1) summary
    cd00162
    Location:78122
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. NM_007219.4NP_009150.1  RING finger protein 24 isoform 1

    See identical proteins and their annotated locations for NP_009150.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript yet it encodes the shorter isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AL031670, AL096778, BQ181223, CD367454, HY050527, HY140488
    Consensus CDS
    CCDS13074.1
    UniProtKB/Swiss-Prot
    Q9Y225
    Related
    ENSP00000336753, OTTHUMP00000030150, ENST00000336095, OTTHUMT00000077795
    Conserved Domains (1) summary
    cd00162
    Location:78122
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p2 Primary Assembly

    Range
    3929918..4015569 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011529145.1XP_011527447.1  

    See identical proteins and their annotated locations for XP_011527447.1

    UniProtKB/Swiss-Prot
    Q9Y225
    Conserved Domains (1) summary
    cd00162
    Location:99143
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  2. XM_011529146.1XP_011527448.1  

    Conserved Domains (1) summary
    cd00162
    Location:93137
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  3. XM_006723536.2XP_006723599.1  

    See identical proteins and their annotated locations for XP_006723599.1

    UniProtKB/Swiss-Prot
    Q9Y225
    Conserved Domains (1) summary
    cd00162
    Location:78122
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
  4. XM_011529147.1XP_011527449.1  

    Conserved Domains (1) summary
    pfam13639
    Location:99124
    zf-RING_2; Ring finger domain

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    3912055..3996213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)