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mdm4 MDM4 regulator of p53 [ Oncorhynchus tshawytscha (Chinook salmon) ]

Gene ID: 112254514, updated on 15-Mar-2024

Summary

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Gene symbol
mdm4
Gene description
MDM4 regulator of p53
See related
EnsemblRapid:ENSOTSG00005000726
Gene type
protein coding
RefSeq status
MODEL
Organism
Oncorhynchus tshawytscha
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: LG07
Exon count:
12
Annotation release Status Assembly LG Location
101 current Otsh_v2.0 (GCF_018296145.1) LG07 NC_056435.1 (41473466..41489698, complement)
100 previous assembly Otsh_v1.0 (GCF_002872995.1) Chromosome 7 NC_037103.1 (54983588..54999666, complement)

Linkage Group LG07 - NC_056435.1Genomic Context describing neighboring genes Neighboring gene PTPRF interacting protein alpha 4 Neighboring gene myogenin Neighboring gene sortilin 1a Neighboring gene proteasome 20S subunit alpha 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein Mdm4
Names
MDM4, p53 regulator

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Oncorhynchus tshawytscha Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Otsh_v2.0 Primary Assembly

Genomic

  1. NC_056435.1 Reference Otsh_v2.0 Primary Assembly

    Range
    41473466..41489698 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042324428.1 → XP_042180362.1  protein Mdm4 isoform X1

    UniProtKB/TrEMBL
    A0A8C8BUB6
    Conserved Domains (3) summary
    cd16784
    Location:441 → 499
    mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins
    cd17673
    Location:29 → 107
    MDM4; p53-binding domain found in MDM4 and similar proteins
    pfam00641
    Location:312 → 337
    zf-RanBP; Zn-finger in Ran binding protein and others

  2. XM_042324429.1 → XP_042180363.1  protein Mdm4 isoform X2

    UniProtKB/TrEMBL
    A0A8C8BUB6
    Conserved Domains (2) summary
    cd16784
    Location:439 → 497
    mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins
    cd17673
    Location:27 → 105
    MDM4; p53-binding domain found in MDM4 and similar proteins

  3. XM_024427176.2 → XP_024282944.1  protein Mdm4 isoform X4

    UniProtKB/TrEMBL
    A0A8C8BUB6
    Conserved Domains (3) summary
    pfam00641
    Location:276 → 301
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:26 → 106
    SWIB; SWIB/MDM2 domain
    cd16784
    Location:405 → 463
    mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

  4. XM_024427177.2 → XP_024282945.1  protein Mdm4 isoform X5

    UniProtKB/TrEMBL
    A0A8C8BUB6
    Conserved Domains (3) summary
    pfam00641
    Location:271 → 296
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:26 → 106
    SWIB; SWIB/MDM2 domain
    cd16784
    Location:400 → 458
    mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins

  5. XM_024427174.2 → XP_024282942.1  protein Mdm4 isoform X1

    UniProtKB/TrEMBL
    A0A8C8BUB6
    Related
    ENSOTSP00005001308.2, ENSOTST00005001466.2
    Conserved Domains (3) summary
    cd16784
    Location:441 → 499
    mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins
    cd17673
    Location:29 → 107
    MDM4; p53-binding domain found in MDM4 and similar proteins
    pfam00641
    Location:312 → 337
    zf-RanBP; Zn-finger in Ran binding protein and others

  6. XM_024427175.2 → XP_024282943.1  protein Mdm4 isoform X3

    UniProtKB/TrEMBL
    A0A8C8BUB6
    Conserved Domains (3) summary
    pfam00641
    Location:307 → 332
    zf-RanBP; Zn-finger in Ran binding protein and others
    pfam02201
    Location:26 → 106
    SWIB; SWIB/MDM2 domain
    cd16784
    Location:436 → 494
    mRING-HC-C2H2C4_MDM4; Modified RING finger, HC subclass (C2H2C4-type), found in protein MDM4 and similar proteins
Nucleotide Protein
Heading Accession and Version

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