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POLI polymerase (DNA) iota [ Homo sapiens (human) ]

Gene ID: 11201, updated on 26-May-2016
Official Symbol
POLIprovided by HGNC
Official Full Name
polymerase (DNA) iotaprovided by HGNC
Primary source
HGNC:HGNC:9182
See related
Ensembl:ENSG00000101751 HPRD:16094; MIM:605252; Vega:OTTHUMG00000132704
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAD30B; RAD3OB
Orthologs
Location:
18q21.1
Exon count:
12
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (54269479..54321266)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (51795849..51837583)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372122 Neighboring gene methyl-CpG binding domain protein 2 Neighboring gene small nucleolar RNA, H/ACA box 37 Neighboring gene StAR related lipid transfer domain containing 6 Neighboring gene chromosome 18 open reading frame 54

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • DNA Damage Bypass, organism-specific biosystem (from REACTOME)
    DNA Damage Bypass, organism-specific biosystemIn addition to various processes for removing lesions from the DNA, cells have developed specific mechanisms for tolerating unrepaired damage during the replication of the genome. These mechanisms ar...
  • DNA Repair, organism-specific biosystem (from REACTOME)
    DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. Living organisms are constantly exposed to harmful metabolic by-products, enviro...
  • Fanconi anemia pathway, organism-specific biosystem (from KEGG)
    Fanconi anemia pathway, organism-specific biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Fanconi anemia pathway, conserved biosystem (from KEGG)
    Fanconi anemia pathway, conserved biosystemThe Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recrui...
  • Termination of translesion DNA synthesis, organism-specific biosystem (from REACTOME)
    Termination of translesion DNA synthesis, organism-specific biosystemThe initiation and extent of translesion DNA synthesis (TLS) has to be tightly controlled in order to limit TLS-induced mutagenesis, caused by the low fidelity of TLS-participating DNA polymerases. S...
  • Translesion synthesis by POLI, organism-specific biosystem (from REACTOME)
    Translesion synthesis by POLI, organism-specific biosystemDNA polymerase iota (POLI) is a Y family DNA polymerase with an active site that favours Hoogsteen base pairing instead of Watson-Crick base pairing. POLI-mediated Hoogsteen base pairing and rotation...
  • Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystem (from REACTOME)
    Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template, organism-specific biosystemUbiquitous environmental and endogenous genotoxic agents cause DNA lesions that can interfere with normal DNA metabolism including DNA replication, eventually resulting in mutations that lead to carc...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-directed DNA polymerase activity TAS
Traceable Author Statement
more info
 
damaged DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA repair TAS
Traceable Author Statement
more info
PubMed 
DNA replication IEA
Inferred from Electronic Annotation
more info
 
error-prone translesion synthesis TAS
Traceable Author Statement
more info
 
translesion synthesis TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
intracellular IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
DNA polymerase iota
Names
RAD30 homolog B
eta2
polymerase (DNA directed) iota
polymerase (DNA-directed), iota
NP_009126.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007195.2NP_009126.2  DNA polymerase iota

    See identical proteins and their annotated locations for NP_009126.2

    Status: VALIDATED

    Source sequence(s)
    AC093462, BC032662, BM993293, DA315805, DB450447
    Consensus CDS
    CCDS11954.2
    UniProtKB/Swiss-Prot
    Q9UNA4
    Related
    ENSP00000462664, OTTHUMP00000163557, ENST00000579534, OTTHUMT00000256002
    Conserved Domains (2) summary
    cd01703
    Location:56437
    PolY_Pol_iota; DNA Polymerase iota
    COG0389
    Location:53390
    DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    54269479..54321266
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006722378.2XP_006722441.1  

    See identical proteins and their annotated locations for XP_006722441.1

    Conserved Domains (2) summary
    PRK02406
    Location:61426
    PRK02406; DNA polymerase IV; Validated
    cl12025
    Location:56423
    PolY; Y-family of DNA polymerases
  2. XM_011525797.1XP_011524099.1  

    See identical proteins and their annotated locations for XP_011524099.1

    Conserved Domains (2) summary
    PRK02406
    Location:61426
    PRK02406; DNA polymerase IV; Validated
    cl12025
    Location:56423
    PolY; Y-family of DNA polymerases
  3. XM_005258192.3XP_005258249.1  

    Conserved Domains (2) summary
    COG0389
    Location:53390
    DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]
    cl12025
    Location:56399
    PolY; Y-family of DNA polymerases
  4. XM_005258188.2XP_005258245.1  

    See identical proteins and their annotated locations for XP_005258245.1

    Related
    ENSP00000462681, OTTHUMP00000262242, ENST00000579434, OTTHUMT00000447961
    Conserved Domains (2) summary
    cd01703
    Location:1369
    PolY_Pol_iota; DNA Polymerase iota
    COG0389
    Location:1322
    DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]
  5. XM_011525796.1XP_011524098.1  

    See identical proteins and their annotated locations for XP_011524098.1

    Related
    ENSP00000217800, OTTHUMP00000262579, ENST00000217800, OTTHUMT00000448457
    Conserved Domains (2) summary
    cd01703
    Location:1369
    PolY_Pol_iota; DNA Polymerase iota
    COG0389
    Location:1322
    DinP; Nucleotidyltransferase/DNA polymerase involved in DNA repair [Replication, recombination and repair]
  6. XM_005258191.3XP_005258248.1  

    Conserved Domains (1) summary
    cl12025
    Location:8256
    PolY; Y-family of DNA polymerases

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    51790805..51819561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)