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CHKA choline kinase alpha [ Homo sapiens (human) ]

Gene ID: 1119, updated on 12-May-2016
Official Symbol
CHKAprovided by HGNC
Official Full Name
choline kinase alphaprovided by HGNC
Primary source
HGNC:HGNC:1937
See related
Ensembl:ENSG00000110721 HPRD:00327; MIM:118491; Vega:OTTHUMG00000167424
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CK; EK; CHK; CKI
Summary
The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
Location:
11q13.2
Exon count:
17
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (68052859..68121391, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (67820326..67888858, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NADH:ubiquinone oxidoreductase core subunit S8 Neighboring gene microRNA 4691 Neighboring gene T-cell immune regulator 1, ATPase H+ transporting V0 subunit a3 Neighboring gene microRNA 6753 Neighboring gene uncharacterized LOC105369362 Neighboring gene lysine methyltransferase 5B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
choline binding IEA
Inferred from Electronic Annotation
more info
 
choline kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
choline kinase activity TAS
Traceable Author Statement
more info
 
cholinesterase activity IEA
Inferred from Electronic Annotation
more info
 
drug binding IDA
Inferred from Direct Assay
more info
PubMed 
ethanolamine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
ethanolamine kinase activity TAS
Traceable Author Statement
more info
 
protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
signal transducer activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
CDP-choline pathway IEA
Inferred from Electronic Annotation
more info
 
choline metabolic process IEA
Inferred from Electronic Annotation
more info
 
ethanolamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
lipid transport TAS
Traceable Author Statement
more info
PubMed 
phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylcholine biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylethanolamine biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylethanolamine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
phosphatidylethanolamine biosynthetic process TAS
Traceable Author Statement
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
response to 3-methylcholanthrene IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
Preferred Names
choline kinase alpha
Names
CHETK-alpha
ethanolamine kinase
NP_001268.2
NP_997634.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277.2NP_001268.2  choline kinase alpha isoform a

    See identical proteins and their annotated locations for NP_001268.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC036471, BG703955, BG723115, BI195927, BU617910, D10704
    Consensus CDS
    CCDS8178.1
    UniProtKB/Swiss-Prot
    P35790
    Related
    ENSP00000265689, OTTHUMP00000235913, ENST00000265689, OTTHUMT00000394570
    Conserved Domains (2) summary
    PLN02236
    Location:99455
    PLN02236; choline kinase
    cd05156
    Location:111452
    ChoK_euk; Euykaryotic Choline Kinase
  2. NM_212469.1NP_997634.1  choline kinase alpha isoform b

    See identical proteins and their annotated locations for NP_997634.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AI809679, AK054792, BC036471, BE260889, BG703955, BG723115, BU617910, D10704
    Consensus CDS
    CCDS8179.1
    UniProtKB/Swiss-Prot
    P35790
    Related
    ENSP00000348454, OTTHUMP00000235915, ENST00000356135, OTTHUMT00000394572
    Conserved Domains (2) summary
    PLN02236
    Location:99437
    PLN02236; choline kinase
    cd05156
    Location:111434
    ChoK_euk; Euykaryotic Choline Kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    68052859..68121391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_949772.1 RNA Sequence

  2. XR_949773.1 RNA Sequence

  3. XR_428904.2 RNA Sequence

  4. XR_949774.1 RNA Sequence

  5. XR_949775.1 RNA Sequence

  6. XR_428905.1 RNA Sequence

  7. XR_949776.1 RNA Sequence

  8. XR_949777.1 RNA Sequence

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    67704080..67773223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)