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NUDT3 nudix hydrolase 3 [ Homo sapiens (human) ]

Gene ID: 11165, updated on 26-May-2016
Official Symbol
NUDT3provided by HGNC
Official Full Name
nudix hydrolase 3provided by HGNC
Primary source
HGNC:HGNC:8050
See related
Ensembl:ENSG00000272325 HPRD:14849; MIM:609228; Vega:OTTHUMG00000014545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIPP; DIPP1; DIPP-1
Summary
NUDT3 belongs to the MutT, or Nudix, protein family. Nudix proteins act as homeostatic checkpoints at important stages in nucleoside phosphate metabolic pathways, guarding against elevated levels of potentially dangerous intermediates, like 8-oxo-dGTP, which promotes AT-to-CG transversions (Safrany et al., 1998 [PubMed 9822604]).[supplied by OMIM, Feb 2011]
Orthologs
Location:
6p21.2
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (34287194..34392680, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (34254971..34360457, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723521 Neighboring gene ribosomal protein L35 pseudogene 2 Neighboring gene RPS10-NUDT3 readthrough Neighboring gene ribosomal protein S10 Neighboring gene protein kinase C and casein kinase substrate in neurons 1

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Identification of 15 loci influencing height in a Korean population.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
NHGRI GWA Catalog

Replication interactions

Interaction Pubs
Knockdown of nudix (nucleoside diphosphate linked moiety X)-type motif 3 (NUDT3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

  • Inositol phosphate metabolism, organism-specific biosystem (from REACTOME)
    Inositol phosphate metabolism, organism-specific biosystemInositol phosphates (IPs) are molecules involves in signalling processes in eukaryotes. myo-Inositol consists of a six-carbon cyclic alcohol with an axial 2-hydroxy and five equatorial hydroxyls. M...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Synthesis of pyrophosphates in the cytosol, organism-specific biosystem (from REACTOME)
    Synthesis of pyrophosphates in the cytosol, organism-specific biosystemInositol phosphates such as IP4, IP5 and IP6 are converted to an even wider variety of IPs including the di- and triphospho inositol phosphates, also known as pyrophosphates (Irvine & Schell 2001, Al...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Readthrough RPS10-NUDT3

Readthrough gene: RPS10-NUDT3, Included gene: RPS10

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
diadenosine polyphosphate catabolic process TAS
Traceable Author Statement
more info
PubMed 
diphosphoinositol polyphosphate catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
inositol phosphate metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
diphosphoinositol polyphosphate phosphohydrolase 1
Names
diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 1
nucleoside diphosphate-linked moiety X motif 3
nudix (nucleoside diphosphate linked moiety X)-type motif 3
nudix motif 3
NP_006694.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006703.3NP_006694.1  diphosphoinositol polyphosphate phosphohydrolase 1

    See identical proteins and their annotated locations for NP_006694.1

    Status: VALIDATED

    Source sequence(s)
    BC007727, CA430332, DA803962, Z98036
    Consensus CDS
    CCDS4791.1
    UniProtKB/Swiss-Prot
    O95989
    Related
    ENSP00000476119, OTTHUMP00000016227, ENST00000607016, OTTHUMT00000040224
    Conserved Domains (1) summary
    cd04666
    Location:19131
    Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

    Range
    34287194..34392680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018917.2 Alternate CHM1_1.1

    Range
    34257511..34362976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)