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fgd4a FYVE, RhoGEF and PH domain containing 4a [ Amphiprion ocellaris (clown anemonefish) ]

Gene ID: 111567807, updated on 3-Apr-2024

Summary

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Gene symbol
fgd4a
Gene description
FYVE, RhoGEF and PH domain containing 4a
See related
EnsemblRapid:ENSAOCG00000007460
Gene type
protein coding
RefSeq status
MODEL
Organism
Amphiprion ocellaris
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Pomacentridae; Amphiprion
Also known as
fgd4
Orthologs
human zebrafish all
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Genomic context

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Location:
chromosome: 3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_03 current ASM2253959v1 (GCF_022539595.1) 3 NC_072768.1 (1692419..1753822, complement)
101 previous assembly AmpOce1.0 (GCF_002776465.1) Unplaced Scaffold NW_019371939.1 (69873..130862)

Chromosome 3 - NC_072768.1Genomic Context describing neighboring genes Neighboring gene acylglycerol kinase Neighboring gene nucleoporin 205 Neighboring gene uncharacterized LOC129348546 Neighboring gene bicaudal D homolog 1a Neighboring gene uncharacterized LOC111567809 Neighboring gene intestine-specific homeobox

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in filopodium assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
FYVE, RhoGEF and PH domain-containing protein 4a
Names
FYVE, RhoGEF and PH domain containing 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_022539595.1-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM2253959v1 Primary Assembly

Genomic

  1. NC_072768.1 Reference ASM2253959v1 Primary Assembly

    Range
    1692419..1753822 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023269123.3 → XP_023124891.1  FYVE, RhoGEF and PH domain-containing protein 4a isoform X1

    Related
    ENSAOCP00000035577.1, ENSAOCT00000043005.1
    Conserved Domains (5) summary
    cd00160
    Location:323 → 505
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:746 → 848
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:537 → 630
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:664 → 728
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    pfam05110
    Location:66 → 296
    AF-4; AF-4 proto-oncoprotein

  2. XM_035947620.2 → XP_035803513.1  FYVE, RhoGEF and PH domain-containing protein 4a isoform X4

    Conserved Domains (4) summary
    cd00160
    Location:307 → 489
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:730 → 832
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:521 → 614
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:648 → 712
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

  3. XM_023269124.3 → XP_023124892.2  FYVE, RhoGEF and PH domain-containing protein 4a isoform X2

    Related
    ENSAOCP00000067587.1, ENSAOCT00000085900.1
    Conserved Domains (4) summary
    cd00160
    Location:296 → 478
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:719 → 821
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:510 → 603
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:637 → 701
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

  4. XM_035947619.2 → XP_035803512.1  FYVE, RhoGEF and PH domain-containing protein 4a isoform X3

    Related
    ENSAOCP00000069651.1, ENSAOCT00000072243.1
    Conserved Domains (4) summary
    cd00160
    Location:311 → 493
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:734 → 836
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:525 → 618
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:652 → 716
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4

  5. XM_023269126.3 → XP_023124894.1  FYVE, RhoGEF and PH domain-containing protein 4a isoform X6

    UniProtKB/TrEMBL
    A0A3Q1ARV9
    Related
    ENSAOCP00000062191.1, ENSAOCT00000066606.1
    Conserved Domains (4) summary
    cd00160
    Location:180 → 362
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:603 → 705
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15741
    Location:521 → 585
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
    cl17171
    Location:394 → 487
    PH-like; Pleckstrin homology-like domain

  6. XM_035947621.2 → XP_035803514.2  FYVE, RhoGEF and PH domain-containing protein 4a isoform X5

    Related
    ENSAOCP00000045800.1, ENSAOCT00000071476.1

  7. XM_023269127.3 → XP_023124895.1  FYVE, RhoGEF and PH domain-containing protein 4a isoform X7

    UniProtKB/TrEMBL
    A0A3Q1ARV9
    Related
    ENSAOCP00000067292.1, ENSAOCT00000082411.1
    Conserved Domains (4) summary
    cd00160
    Location:178 → 360
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd13236
    Location:601 → 703
    PH2_FGD1-4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins pleckstrin homology (PH) domain, C-terminus
    cd15791
    Location:392 → 485
    PH1_FDG4; FYVE, RhoGEF and PH domain containing/faciogenital dysplasia proteins 4, N-terminal Pleckstrin homology (PH) domain
    cd15741
    Location:519 → 583
    FYVE_FGD1_2_4; FYVE domain found in FYVE, RhoGEF and PH domain-containing protein facio-genital dysplasia FGD1, FGD2, FGD4
Nucleotide Protein
Heading Accession and Version

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