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TIMP4 TIMP metallopeptidase inhibitor 4 [ Piliocolobus tephrosceles (Ugandan red Colobus) ]

Gene ID: 111546913, updated on 15-Mar-2024

Summary

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Gene symbol
TIMP4
Gene description
TIMP metallopeptidase inhibitor 4
See related
Ensembl:ENSPTEG00000037942
Gene type
protein coding
RefSeq status
MODEL
Organism
Piliocolobus tephrosceles
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Piliocolobus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
5
Annotation release Status Assembly Chr Location
102 current ASM277652v3 (GCF_002776525.3) 2 NC_045435.1 (48938006..48944223)
100 previous assembly ASM277652v1 (GCF_002776525.1) Unplaced Scaffold NW_019317444.1 (561872..568089)

Chromosome 2 - NC_045435.1Genomic Context describing neighboring genes Neighboring gene peroxisome proliferator activated receptor gamma Neighboring gene glutathione S-transferase Mu 1 pseudogene Neighboring gene synapsin II Neighboring gene actin-related protein 2/3 complex subunit 3-like Neighboring gene actin, cytoplasmic 2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protease binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to organic substance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
metalloproteinase inhibitor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Piliocolobus tephrosceles Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM277652v3

Genomic

  1. NC_045435.1 Reference ASM277652v3

    Range
    48938006..48944223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023218415.1 → XP_023074183.1  metalloproteinase inhibitor 4

    UniProtKB/TrEMBL
    A0A8C9ISP7
    Related
    ENSPTEP00000041415.1, ENSPTET00000055328.1
    Conserved Domains (1) summary
    cd03585
    Location:30 → 213
    NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...
Nucleotide Protein
Heading Accession and Version

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