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KAT7 K(lysine) acetyltransferase 7 [ Homo sapiens (human) ]

Gene ID: 11143, updated on 12-Apr-2014
Official Symbol
KAT7provided by HGNC
Official Full Name
K(lysine) acetyltransferase 7provided by HGNC
Primary source
HGNC:17016
See related
Ensembl:ENSG00000136504; HPRD:07135; MIM:609880; Vega:OTTHUMG00000161770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBO1; HBOA; MYST2; ZC2HC7
Location :
17q21.32
Sequence :
Chromosome: 17; NC_000017.11 (49788619..49829096)
See KAT7 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member B1 Neighboring gene family with sequence similarity 117, member A Neighboring gene uncharacterized LOC729220 Neighboring gene tachykinin 4 (hemokinin) Neighboring gene mRNA turnover 4 homolog (S. cerevisiae) pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
pol gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

Go to the HIV-1, Human Protein Interaction Database

  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Chromatin modifying enzymes, organism-specific biosystem (from REACTOME)
    Chromatin modifying enzymes, organism-specific biosystemEukaryotic DNA is associated with histone proteins and organized into a complex nucleoprotein structure called chromatin. This structure decreases the accessibility of DNA but also helps to protect i...
  • Chromatin organization, organism-specific biosystem (from REACTOME)
    Chromatin organization, organism-specific biosystemChromatin organization refers to the composition and conformation of complexes between DNA, protein and RNA. It is determined by processes that result in the specification, formation or maintenance o...
  • HATs acetylate histones, organism-specific biosystem (from REACTOME)
    HATs acetylate histones, organism-specific biosystemHistone acetyltransferases (HATs) involved in histone modifications are referred to as A-type or nuclear HATs. They can be grouped into at least four families based on sequence conservation within th...
  • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Androgen receptor activity, organism-specific biosystem
    Regulation of Androgen receptor activity
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
histone acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
chromatin organization TAS
Traceable Author Statement
more info
 
histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K12 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
NOT histone H4-K16 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K5 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H4-K8 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
histone acetyltransferase complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
histone acetyltransferase KAT7
Names
histone acetyltransferase KAT7
MYST-2
lysine acetyltransferase 7
histone acetyltransferase MYST2
MYST histone acetyltransferase 2
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
histone acetyltransferase binding to ORC1
NP_001186084.1
NP_001186085.1
NP_001186086.1
NP_001186087.1
NP_008998.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199155.1NP_001186084.1  histone acetyltransferase KAT7 isoform 2

    See proteins identical to NP_001186084.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AF217502, AK294836, DC306552
    Consensus CDS
    CCDS56035.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000398961, OTTHUMP00000220717, ENST00000424009, OTTHUMT00000366037
    Conserved Domains (2) summary
    pfam01530
    Location:182212
    Blast Score: 162
    zf-C2HC; Zinc finger, C2HC type
    cl19766
    Location:299577
    Blast Score: 953
    MOZ_SAS; MOZ/SAS family
  2. NM_001199156.1NP_001186085.1  histone acetyltransferase KAT7 isoform 3

    See proteins identical to NP_001186085.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC015795, AF217502, AK293976, DC306552
    Consensus CDS
    CCDS56037.1
    UniProtKB/Swiss-Prot
    O95251
    Conserved Domains (2) summary
    pfam01530
    Location:5273
    Blast Score: 103
    zf-C2HC; Zinc finger, C2HC type
    cl19766
    Location:198450
    Blast Score: 945
    MOZ_SAS; MOZ/SAS family
  3. NM_001199157.1NP_001186086.1  histone acetyltransferase KAT7 isoform 4

    See proteins identical to NP_001186086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF217502, AK294014, DC306552
    Consensus CDS
    CCDS56036.1
    UniProtKB/Swiss-Prot
    O95251
    Conserved Domains (2) summary
    pfam01530
    Location:113132
    Blast Score: 101
    zf-C2HC; Zinc finger, C2HC type
    cl19766
    Location:219479
    Blast Score: 947
    MOZ_SAS; MOZ/SAS family
  4. NM_001199158.1NP_001186087.1  histone acetyltransferase KAT7 isoform 5

    See proteins identical to NP_001186087.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks three alternate in-frame exons compared to variant 1. The resulting isoform (5) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF217502, AK294052, DC306552
    Consensus CDS
    CCDS56038.1
    UniProtKB/Swiss-Prot
    O95251
    Conserved Domains (2) summary
    pfam01530
    Location:5273
    Blast Score: 103
    zf-C2HC; Zinc finger, C2HC type
    cl19766
    Location:168420
    Blast Score: 942
    MOZ_SAS; MOZ/SAS family
  5. NM_007067.4NP_008998.1  histone acetyltransferase KAT7 isoform 1

    See proteins identical to NP_008998.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF217502, DC306552
    Consensus CDS
    CCDS11554.1
    UniProtKB/Swiss-Prot
    O95251
    Related
    ENSP00000259021, OTTHUMP00000220713, ENST00000259021, OTTHUMT00000366032
    Conserved Domains (2) summary
    pfam01530
    Location:182212
    Blast Score: 163
    zf-C2HC; Zinc finger, C2HC type
    cl19766
    Location:329607
    Blast Score: 955
    MOZ_SAS; MOZ/SAS family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38 Primary Assembly

    Range
    49788619..49829096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000149.1 Alternate HuRef

    Range
    43230982..43271467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018928.2 Alternate CHM1_1.1

    Range
    47929929..47970416
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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