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CDC42EP1 CDC42 effector protein 1 [ Homo sapiens (human) ]

Gene ID: 11135, updated on 12-May-2016
Official Symbol
CDC42EP1provided by HGNC
Official Full Name
CDC42 effector protein 1provided by HGNC
Primary source
HGNC:HGNC:17014
See related
Ensembl:ENSG00000128283 HPRD:07303; MIM:606084; Vega:OTTHUMG00000150591
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEP1; BORG5; MSE55
Summary
CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]
Orthologs
Location:
22q13.1
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 22 NC_000022.11 (37559778..37569405)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (37956471..37965412)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase Neighboring gene caspase recruitment domain family member 10 Neighboring gene galectin 2 Neighboring gene golgi-associated, gamma adaptin ear containing, ARF binding protein 1

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC15316

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTP-Rho binding IBA
Inferred from Biological aspect of Ancestor
more info
 
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of pseudopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
Preferred Names
cdc42 effector protein 1
Names
55 kDa bone marrow stromal/endothelial cell protein
CDC42 effector protein (Rho GTPase binding) 1
binder of Rho GTPases 5
serum constituent protein
serum protein MSE55

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152243.2NP_689449.1  cdc42 effector protein 1

    See identical proteins and their annotated locations for NP_689449.1

    Status: REVIEWED

    Source sequence(s)
    BC009356, CR456524, DA047271
    Consensus CDS
    CCDS13949.1
    UniProtKB/Swiss-Prot
    Q00587
    Related
    ENSP00000249014, OTTHUMP00000197884, ENST00000249014, OTTHUMT00000318993
    Conserved Domains (2) summary
    pfam00786
    Location:3767
    PBD; P21-Rho-binding domain
    pfam14957
    Location:117214
    BORG_CEP; Cdc42 effector

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p2 Primary Assembly

    Range
    37559778..37569405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724109.1XP_006724172.1  

    See identical proteins and their annotated locations for XP_006724172.1

    UniProtKB/Swiss-Prot
    Q00587
    Conserved Domains (2) summary
    pfam00786
    Location:3767
    PBD; P21-Rho-binding domain
    pfam14957
    Location:117214
    BORG_CEP; Cdc42 effector
  2. XM_006724108.1XP_006724171.1  

    See identical proteins and their annotated locations for XP_006724171.1

    UniProtKB/Swiss-Prot
    Q00587
    Conserved Domains (2) summary
    pfam00786
    Location:3767
    PBD; P21-Rho-binding domain
    pfam14957
    Location:117214
    BORG_CEP; Cdc42 effector
  3. XM_006724107.1XP_006724170.1  

    See identical proteins and their annotated locations for XP_006724170.1

    UniProtKB/Swiss-Prot
    Q00587
    Conserved Domains (2) summary
    pfam00786
    Location:3767
    PBD; P21-Rho-binding domain
    pfam14957
    Location:117214
    BORG_CEP; Cdc42 effector

Alternate CHM1_1.1

Genomic

  1. NC_018933.2 Alternate CHM1_1.1

    Range
    37915221..37924140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)