Display Settings:

Format

Send to:

Choose Destination

POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa [ Homo sapiens (human) ]

Gene ID: 11128, updated on 13-Jan-2015
Official Symbol
POLR3Aprovided by HGNC
Official Full Name
polymerase (RNA) III (DNA directed) polypeptide A, 155kDaprovided by HGNC
Primary source
HGNC:HGNC:30074
See related
Ensembl:ENSG00000148606; HPRD:17879; MIM:614258; Vega:OTTHUMG00000018550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADDH; HLD7; RPC1; RPC155; hRPC155
Summary
The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response. [provided by RefSeq, Aug 2011]
Orthologs
See POLR3A in MapViewer
Location:
10q22-q23
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 10 NC_000010.11 (77975149..78029540, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (79734907..79789298, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene DLG5 antisense RNA 1 Neighboring gene H2A histone family, member Z pseudogene 5 Neighboring gene ribosomal protein S24 Neighboring gene guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 pseudogene 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of polymerase (RNA) III (DNA directed) polypeptide A, (POLR3A) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed RNA polymerase activity NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
ribonucleoside binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
defense response to virus IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
innate immune response TAS
Traceable Author Statement
more info
 
positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
termination of RNA polymerase III transcription TAS
Traceable Author Statement
more info
 
transcription elongation from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
transcription from RNA polymerase III promoter TAS
Traceable Author Statement
more info
 
transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
DNA-directed RNA polymerase III complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
Preferred Names
DNA-directed RNA polymerase III subunit RPC1
Names
DNA-directed RNA polymerase III subunit RPC1
RNA polymerase III subunit C1
RNA polymerase III subunit C160
RNA polymerase III 155 kDa subunit
RNA polymerase III subunit RPC155-D
DNA-directed RNA polymerase III subunit A
DNA-directed RNA polymerase III largest subunit
NP_008986.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029648.1 

    Range
    5001..59392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_007055.3NP_008986.2  DNA-directed RNA polymerase III subunit RPC1

    See proteins identical to NP_008986.2

    Status: REVIEWED

    Source sequence(s)
    AK024744, AY091459, BC041089, CA449326, DA103416, DA353439
    Consensus CDS
    CCDS7354.1
    UniProtKB/Swiss-Prot
    O14802
    Related
    ENSP00000361446, OTTHUMP00000019920, ENST00000372371, OTTHUMT00000048923
    Conserved Domains (4) summary
    cd02736
    Location:10211360
    RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
    pfam04998
    Location:8411318
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
    PRK08566
    Location:7930
    PRK08566; DNA-directed RNA polymerase subunit A'; Validated
    cd02583
    Location:24891
    RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000010.11 

    Range
    77975149..78029540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006717597.1XP_006717660.1  

    Conserved Domains (4) summary
    cd02736
    Location:10001339
    RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
    pfam04998
    Location:8201297
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5
    PRK08566
    Location:3909
    PRK08566; DNA-directed RNA polymerase subunit A'; Validated
    cd02583
    Location:3870
    RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain

Alternate CHM1_1.1

Genomic

  1. NC_018921.2 

    Range
    80017697..80072040
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000142.1 

    Range
    73729855..73784226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)