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TSC2 TSC complex subunit 2 [ Delphinapterus leucas (beluga whale) ]

Gene ID: 111185176, updated on 15-Mar-2024

Summary

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Gene symbol
TSC2
Gene description
TSC complex subunit 2
See related
Ensembl:ENSDLEG00000007869
Gene type
protein coding
RefSeq status
MODEL
Organism
Delphinapterus leucas
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Monodontidae; Delphinapterus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
43
Annotation release Status Assembly Chr Location
101 current ASM228892v3 (GCF_002288925.2) Unplaced Scaffold NW_022098040.1 (12009330..12046599)
100 previous assembly ASM228892v2 (GCF_002288925.1) Unplaced Scaffold NW_019160905.1 (12010046..12047321)

NW_022098040.1Genomic Context describing neighboring genes Neighboring gene NHERF family PDZ scaffold protein 2 Neighboring gene nth like DNA glycosylase 1 Neighboring gene polycystin 1, transient receptor potential channel interacting Neighboring gene RAB26, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of TSC1-TSC2 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tuberin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Delphinapterus leucas Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM228892v3 Primary Assembly

Genomic

  1. NW_022098040.1 Reference ASM228892v3 Primary Assembly

    Range
    12009330..12046599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022594520.2 → XP_022450228.1  tuberin isoform X8

    UniProtKB/TrEMBL
    A0A2Y9Q484
    Related
    ENSDLEP00000015569.1, ENSDLET00000017198.1
    Conserved Domains (3) summary
    pfam02145
    Location:1568 → 1754
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555 → 903
    Tuberin
    pfam11864
    Location:55 → 469
    DUF3384; Domain of unknown function (DUF3384)

  2. XM_022594512.2 → XP_022450220.1  tuberin isoform X1

    UniProtKB/TrEMBL
    A0A2Y9PXK2
    Conserved Domains (3) summary
    pfam02145
    Location:1525 → 1711
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555 → 903
    Tuberin
    pfam11864
    Location:55 → 469
    DUF3384; Domain of unknown function (DUF3384)

  3. XM_022594515.2 → XP_022450223.1  tuberin isoform X4

    UniProtKB/TrEMBL
    A0A2Y9Q480
    Related
    ENSDLEP00000014680.1, ENSDLET00000016209.1
    Conserved Domains (3) summary
    pfam02145
    Location:1502 → 1688
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555 → 903
    Tuberin
    pfam11864
    Location:55 → 469
    DUF3384; Domain of unknown function (DUF3384)

  4. XM_022594513.2 → XP_022450221.1  tuberin isoform X2

    UniProtKB/TrEMBL
    A0A2Y9PYI2
    Conserved Domains (3) summary
    pfam02145
    Location:1524 → 1710
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555 → 903
    Tuberin
    pfam11864
    Location:55 → 469
    DUF3384; Domain of unknown function (DUF3384)

  5. XM_022594516.2 → XP_022450224.1  tuberin isoform X5

    UniProtKB/TrEMBL
    A0A2Y9PTM1
    Conserved Domains (3) summary
    pfam02145
    Location:1501 → 1687
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555 → 903
    Tuberin
    pfam11864
    Location:55 → 469
    DUF3384; Domain of unknown function (DUF3384)

  6. XM_022594514.2 → XP_022450222.1  tuberin isoform X3

    UniProtKB/TrEMBL
    A0A2Y9Q3U6
    Conserved Domains (3) summary
    pfam02145
    Location:1505 → 1691
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555 → 883
    Tuberin
    pfam11864
    Location:55 → 469
    DUF3384; Domain of unknown function (DUF3384)

  7. XM_022594518.1 → XP_022450226.1  tuberin isoform X6

    UniProtKB/TrEMBL
    A0A2Y9PYI6
    Related
    ENSDLEP00000015781.1, ENSDLET00000017424.1
    Conserved Domains (3) summary
    pfam02145
    Location:1525 → 1579
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:555 → 903
    Tuberin
    pfam11864
    Location:55 → 469
    DUF3384; Domain of unknown function (DUF3384)

  8. XM_022594519.2 → XP_022450227.1  tuberin isoform X7

    UniProtKB/TrEMBL
    A0A2Y9Q3V0
    Conserved Domains (3) summary
    pfam02145
    Location:1325 → 1511
    Rap_GAP; Rap/ran-GAP
    pfam03542
    Location:355 → 703
    Tuberin
    pfam11864
    Location:1 → 269
    DUF3384; Domain of unknown function (DUF3384)
Nucleotide Protein
Heading Accession and Version

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