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TRAF5 TNF receptor associated factor 5 [ Delphinapterus leucas (beluga whale) ]

Gene ID: 111184706, updated on 15-Mar-2024

Summary

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Gene symbol
TRAF5
Gene description
TNF receptor associated factor 5
See related
Ensembl:ENSDLEG00000005364
Gene type
protein coding
RefSeq status
MODEL
Organism
Delphinapterus leucas
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Monodontidae; Delphinapterus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
17
Annotation release Status Assembly Chr Location
101 current ASM228892v3 (GCF_002288925.2) Unplaced Scaffold NW_022098019.1 (15447451..15491724, complement)
100 previous assembly ASM228892v2 (GCF_002288925.1) Unplaced Scaffold NW_019160903.1 (8067837..8112111, complement)

NW_022098019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111184705 Neighboring gene RD3 regulator of GUCY2D Neighboring gene REST corepressor 3 Neighboring gene 28S ribosomal protein S7, mitochondrial pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables thioesterase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tumor necrosis factor receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of plasma membrane signaling receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
TNF receptor-associated factor 5

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Delphinapterus leucas Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM228892v3 Primary Assembly

Genomic

  1. NW_022098019.1 Reference ASM228892v3 Primary Assembly

    Range
    15447451..15491724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022593443.1 → XP_022449151.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  2. XM_022593449.1 → XP_022449157.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  3. XM_022593444.1 → XP_022449152.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  4. XM_022593450.1 → XP_022449158.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  5. XM_022593453.1 → XP_022449161.1  TNF receptor-associated factor 5 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9PVD2
    Related
    ENSDLEP00000007254.1, ENSDLET00000008028.1
    Conserved Domains (4) summary
    COG1196
    Location:230 → 420
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd03780
    Location:404 → 551
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:128 → 183
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins

  6. XM_022593448.2 → XP_022449156.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  7. XM_022593451.2 → XP_022449159.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  8. XM_022593447.2 → XP_022449155.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  9. XM_022593446.2 → XP_022449154.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  10. XM_022593445.1 → XP_022449153.1  TNF receptor-associated factor 5 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9Q0U5
    Conserved Domains (5) summary
    cd03780
    Location:462 → 609
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:186 → 241
    zf-TRAF; TRAF-type zinc finger
    cd16642
    Location:43 → 85
    mRING-HC-C3HC3D_TRAF5; Modified RING finger, HC subclass (C3HC3D-type), found in tumor necrosis factor (TNF) receptor-associated factor 5 (TRAF5) and similar proteins
    cl25732
    Location:288 → 478
    SMC_N; RecF/RecN/SMC N terminal domain
    cl28410
    Location:38 → 220
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  11. XM_022593452.1 → XP_022449160.1  TNF receptor-associated factor 5 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9PUE4
    Conserved Domains (3) summary
    cd03780
    Location:429 → 576
    MATH_TRAF5; Tumor Necrosis Factor Receptor (TNFR)-Associated Factor (TRAF) family, TRAF5 subfamily, TRAF domain, C-terminal MATH subdomain; TRAF molecules serve as adapter proteins that link TNFRs and downstream kinase cascades resulting in the activation of ...
    pfam02176
    Location:153 → 208
    zf-TRAF; TRAF-type zinc finger
    cl25732
    Location:255 → 445
    SMC_N; RecF/RecN/SMC N terminal domain
Nucleotide Protein
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