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HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 [ Delphinapterus leucas (beluga whale) ]

Gene ID: 111183432, updated on 15-Mar-2024

Summary

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Gene symbol
HERC4
Gene description
HECT and RLD domain containing E3 ubiquitin protein ligase 4
See related
Ensembl:ENSDLEG00000011906
Gene type
protein coding
RefSeq status
MODEL
Organism
Delphinapterus leucas
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Monodontidae; Delphinapterus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
29
Annotation release Status Assembly Chr Location
101 current ASM228892v3 (GCF_002288925.2) Unplaced Scaffold NW_022098057.1 (64133207..64264871)
100 previous assembly ASM228892v2 (GCF_002288925.1) Unplaced Scaffold NW_019160899.1 (3447377..3579030, complement)

NW_022098057.1Genomic Context describing neighboring genes Neighboring gene myopalladin Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene transfer RNA tryptophan (anticodon CCA) Neighboring gene sirtuin 1 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Delphinapterus leucas Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM228892v3 Primary Assembly

Genomic

  1. NW_022098057.1 Reference ASM228892v3 Primary Assembly

    Range
    64133207..64264871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022590701.2 → XP_022446409.1  probable E3 ubiquitin-protein ligase HERC4 isoform X6

    UniProtKB/TrEMBL
    A0A2Y9PHJ5
    Conserved Domains (1) summary
    cl27697
    Location:2 → 344
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  2. XM_022590696.2 → XP_022446404.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9PTV6
    Conserved Domains (2) summary
    cd00078
    Location:728 → 1074
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:2 → 344
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  3. XM_022590695.2 → XP_022446403.1  probable E3 ubiquitin-protein ligase HERC4 isoform X1

    UniProtKB/TrEMBL
    A0A2Y9PTV6
    Conserved Domains (2) summary
    cd00078
    Location:728 → 1074
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:2 → 344
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  4. XM_022590697.2 → XP_022446405.1  probable E3 ubiquitin-protein ligase HERC4 isoform X2

    UniProtKB/TrEMBL
    A0A2Y9PKV6
    Conserved Domains (2) summary
    cd00078
    Location:720 → 1066
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:2 → 344
    RCC1; Regulator of chromosome condensation (RCC1) repeat

  5. XM_022590698.2 → XP_022446406.1  probable E3 ubiquitin-protein ligase HERC4 isoform X3

    UniProtKB/TrEMBL
    A0A2Y9PMC0
    Related
    ENSDLEP00000016269.1, ENSDLET00000017956.1
    Conserved Domains (2) summary
    COG5184
    Location:2 → 344
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:709 → 1055
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  6. XM_022590699.2 → XP_022446407.1  probable E3 ubiquitin-protein ligase HERC4 isoform X4

    UniProtKB/TrEMBL
    A0A2Y9PSV5
    Related
    ENSDLEP00000016288.1, ENSDLET00000017974.1
    Conserved Domains (2) summary
    COG5184
    Location:2 → 344
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:701 → 1047
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  7. XM_022590700.2 → XP_022446408.1  probable E3 ubiquitin-protein ligase HERC4 isoform X5

    UniProtKB/TrEMBL
    A0A2Y9PTW1
    Conserved Domains (2) summary
    cd00078
    Location:658 → 1004
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cl27697
    Location:12 → 268
    RCC1; Regulator of chromosome condensation (RCC1) repeat

RNA

  1. XR_002647006.2 RNA Sequence

  2. XR_002647007.2 RNA Sequence

  3. XR_002647005.2 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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